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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

L(+ )-arginine

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with L(+ )-arginine

The included studies will be those with critically ill child 1 Conditions such as obesity and type 2 diabetes increase the 1 Phosphodiesterase type 5 inhibitors (PDE5Is) have long been 1 Dental Caries 1 Hypertensive disorders of pregnancy (Gestational hypertensio 1 The effect of L-arginine on changes in body composition will 1 Blood pressure, is the pressure of circulating blood against 1 Patients with type 2 diabetes, active foot ulcer 1 Caries,Dental 1 Human oral micro-environment is an ecological collection com 1 Stroke-like episodes/encephalopathy/seizures/epilepsy (consi 1 blood preassure (hypertensive) 1

📋 Sample Trials

NCT05306925

An Exploratory Study of Arginine Supplementation and the Postoperative Immune REsponse

Recruiting

NCT05299112

An Exploratory Study of Increased Preterm Arginine INTake (PAINT18)

Recruiting

NCT05470998

L-Arginine in Children Having Sickle Cell Disease With Increased Tricuspid Regurgitant Jet Velocity

Recruiting · Phase 3

📊 Sample Meta-Analyses

CRD42018095367

Difference of clinical effectiveness between arginine and calcium sodium phosphosilicate-containing toothpastes to control dentin hypersensitivity: a systematic review

Dentin hypersensitivity: relief and pain control.

CRD42018094448

The effects of oral L-arginine supplementation on serum growth hormone: a meta-analysis of randomized controlled trials

Growth hormone levels. L-arginine is a semi-essential amino acid that has been s

CRD42018094461

The effects of oral L-arginine supplementation on serum insulin-like growth factor 1 (IGF-1): a meta-analysis of randomized controlled trials

Insulin-like growth factor 1 levels. L-arginine is a semi-essential amino acid,

📚 Sample References

None linked yet.

⚗️ All Ingredient data fields for L(+ )-arginine

⚗️ Identity

Name

L(+ )-arginine

Aliases / Synonyms

L-arginine; arginine; 74-79-3; L-(+)-Arginine; (S)-2-Amino-5-guanidinopentanoic acid; L-Arg; H-Arg-OH; L(+)-Arginine; (L)-Arginine; Arginina

🧪 Chemistry

Molecular Weight

174.2040

LogP

-1.5481

Drug-likeness

0.228

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C(CC(C(=O)O)N)CN=C(N)N

Isomeric SMILES

C(C[C@@H](C(=O)O)N)CN=C(N)N

InChIKey

ODKSFYDXXFIFQN-BYPYZUCNSA-N

InChI

InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1

🔗 External References

HERB DB

HBIN032674 ↗

PubChem CID

6322 ↗

TCMID

38336

🔍 Raw view — every non-empty column on this row (27 fields)

name

L(+ )-arginine

common names

L-arginine; arginine; 74-79-3; L-(+)-Arginine; (S)-2-Amino-5-guanidinopentanoic acid; L-Arg; H-Arg-OH; L(+)-Arginine; (L)-Arginine; Arginina

herb ingredient id

HBIN032674

canonical smiles

C(CC(C(=O)O)N)CN=C(N)N

isomeric smiles

C(C[C@@H](C(=O)O)N)CN=C(N)N

inchi

InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1

inchikey

ODKSFYDXXFIFQN-BYPYZUCNSA-N

mol wt

174.2040

num h acceptors

num h donors

mol logp

-1.5481

num rotatable bonds

drug likeness

0.228

tcmid ingredient id

38336

pubchem cid

6322

🏥 Linked Health Topics

2 · studied for these conditions (text bridge)

📋 Clinical Trials

7 · subject of clinical study

NCT05306925 An Exploratory Study of Arginine Supplementation and the Postoperative Immune RE

→ Preterm|Surgery|Nutritional Deficiency|Immune Syst

NCT05299112 An Exploratory Study of Increased Preterm Arginine INTake (PAINT18)

→ Preterm|Nutritional Deficiency|Immune System and R

NCT05470998 L-Arginine in Children Having Sickle Cell Disease With Increased Tricuspid Regur

→ Sickle Cell Disease

NCT05560945 2-year Caries Clinical Study: Arginine Fluoride-Free Toothpastes vs. NaF Toothpa

→ Dental Caries

NCT06135792 The Effect of Arginine on Biofilm Composition, Architecture and Metabolism

→ Dental Caries|Dental Plaque|Microbial Colonization

NCT06182267 Maximal Use Study to Determine the Pharmacokinetics of L-arginine After Exaggera

→ Caries,Dental

NCT06044194 Evaluation of the Effect of Liposomal L-Arg and Vit C Integration on Mitochondri

→ Heart Failure

📊 Meta-Analyses

12 · systematic review

CRD42018095367 Difference of clinical effectiveness between arginine and calcium sodium phospho

→ Dentin hypersensitivity: relief and pain control.

CRD42018094448 The effects of oral L-arginine supplementation on serum growth hormone: a meta-a

→ Growth hormone levels. L-arginine is a semi-essent

CRD42018094461 The effects of oral L-arginine supplementation on serum insulin-like growth fact

→ Insulin-like growth factor 1 levels. L-arginine is

CRD42021242954 Growth hormone response to L-arginine supplementation alone or along with growth

→ L-Arginine has been reported to promote cellular a

CRD42020181230 Is L-Arginine effective in the management of acute and chronic treatment of stro

→ Stroke-like episodes/encephalopathy/seizures/epile

CRD42021287530 The effect of L-arginine, L-citrulline and combined L-arginine with L-citrulline

→ Fatigue during physical performance and potential

CRD42022359806 Influence of arginine and citrulline on biomarkers of inflammation and oxidative

→ Recovering after a physical fitness

CRD42011001339 Efficacy of arginine containing products in treating dentine hypersensitivity: a

→ Dentine hypersensitivity (DH) is defined as a shor

CRD42017077289 Effects of L-arginine supplementation on blood flow responses in patients with c

→ Conditions such as obesity and type 2 diabetes inc

CRD42018094860 Effects of oral L-Arginine supplementation on weight and body composition: a met

→ L-Arg is a semi-essential amino acid that particip

CRD42018108061 Effect of L-arginine supplements on obesity-related anthropometric measures: a s

→ The effect of L-arginine on changes in body compos

CRD42019123728 Effect of arginine supplementation in pediatric critical patients

→ The included studies will be those with critically

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables