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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

L-ascorbic acid

Open on HERB 2.0 ↗

178

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with L-ascorbic acid

Sepsis|Septic Shock 5 Sepsis 4 Septic Shock|Sepsis 3 Vitamin C Deficiency 3 Multiple Myeloma and Plasma Cell Neoplasm 3 Covid-19 2 Cancer 2 Septic Shock 2 Heart Failure 2 Healthy Volunteers 2 Endothelial Dysfunction 2 The effect of treatment with hydrocortisone, ascorbic acid, 1

📋 Sample Trials

NCT00231218

Echinacea, Propolis and Vitamin C for URI Prevention in Preschoolers

Completed · Phase 3

NCT03258684

Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Sepsis and Septic Shock

Completed

NCT03333278

The Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock Trial

Completed · Phase 2

📊 Sample Meta-Analyses

CRD42020203166

Hydrocortisone, ascorbic acid and thiamine for sepsis and septic shock: a meta-analysis

The effect of treatment with hydrocortisone, ascorbic acid, and thiamine for sep

CRD42020207832

Combined treatment with ascorbic acid, hydrocortisone, and thiamine for patients with sepsis and septic shock: a systematic review and meta-analysis

Sepsis rapidly progresses causing multiple organ dysfunction, and is considered

CRD42020220135

Thiamine, ascorbic acid and hydrocortisone as metabolic resuscitation cocktail in sepsis: where is the evidence ? A meta-analysis of randomised controlled trial with trial sequential analysis.

Septic shock, Sepsis, metabolic resuscitation

📚 Sample References

PMID 31476335

Ascorbic acid presents rapid behavioral and hippocampal synaptic plasticity effects

Prog Neuropsychopharmacol Biol Psychiatry · 2020

PMID 31656084

Ascorbic Acid 2-Glucoside Stably Promotes the Primitiveness of Embryonic and Mesenchymal Stem Cells Through Ten-Eleven Translocation- and cAMP-Responsive Element-Binding Protein-1-Dependent Mechanisms

Antioxid Redox Signal · 2020

PMID 31911474

High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model

Proc Natl Acad Sci U S A · 2020

⚗️ All Ingredient data fields for L-ascorbic acid

⚗️ Identity

Name

L-ascorbic acid

Aliases / Synonyms

ascorbic acid; vitamin C; 50-81-7; L-ascorbate; Ascoltin; ascorbate; Ascorbicap; Cevitamic acid; L(+)-Ascorbic acid

🧪 Chemistry

Molecular Weight

176.1240

LogP

-1.4074

Drug-likeness

0.385

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C(C(C1C(=C(C(=O)O1)O)O)O)O

Isomeric SMILES

C([C@@H]([C@@H]1C(=C(C(=O)O1)O)O)O)O

InChIKey

CIWBSHSKHKDKBQ-JLAZNSOCSA-N

InChI

InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1

🔗 External References

HERB DB

HBIN032689 ↗

PubChem CID

54670067 ↗

NPASS

NPC187770

HIT

C0927

TCM-ID

23140

🔍 Raw view — every non-empty column on this row (29 fields)

name

L-ascorbic acid

common names

ascorbic acid; vitamin C; 50-81-7; L-ascorbate; Ascoltin; ascorbate; Ascorbicap; Cevitamic acid; L(+)-Ascorbic acid

herb ingredient id

HBIN032689

canonical smiles

C(C(C1C(=C(C(=O)O1)O)O)O)O

isomeric smiles

C([C@@H]([C@@H]1C(=C(C(=O)O1)O)O)O)O

inchi

InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1

inchikey

CIWBSHSKHKDKBQ-JLAZNSOCSA-N

mol wt

176.1240

num h acceptors

num h donors

mol logp

-1.4074

num rotatable bonds

drug likeness

0.385

tcm id ingredient id

23140

pubchem cid

54670067

npass id

NPC187770

hit id

C0927

🏥 Linked Health Topics

12 · studied for these conditions (text bridge)

Diabetic Neuropathies

📋 Clinical Trials

12 · subject of clinical study

NCT00231218 Echinacea, Propolis and Vitamin C for URI Prevention in Preschoolers

→ Common Cold|Gastroenteritis

NCT03258684 Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Sepsis and Septic S

→ Sepsis

NCT03333278 The Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock Trial

→ Shock, Septic|Critically Ill|Vasoplegic Syndrome|S

NCT03592693 Vitamin C, Hydrocortisone and Thiamine for Septic Shock

→ Shock, Septic

NCT03872011 Vitamin C, Thiamine and Hydrocortisone for the Treatment of Septic Shock

→ Septic Shock

NCT04160676 Therapy With Hydrocortisone, Ascorbic Acid, Thamine in Patients With Sepsis

→ Sepsis

NCT04197115 Vitamin C, Thiamine, Cyanocobalamine, Pyridoxine and Hydrocortisone in Sepsis

→ Sepsis|Septic Shock

NCT00001309 The Body's Affect on Vitamin C

→ Healthy Volunteers

NCT00258245 Arsenic Trioxide and Ascorbic Acid Combined With Bortezomib, Thalidomide, and De

→ Multiple Myeloma and Plasma Cell Neoplasm

NCT00271635 Ascorbic Acid Treatment in CMT1A Trial (AATIC)

→ Charcot-Marie-Tooth Disease|Hereditary Motor and S

NCT00274820 Arsenic Trioxide, Ascorbic Acid, Dexamethasone, and Thalidomide in Myelofibrosis

→ Chronic Myeloproliferative Disorders|Leukemia|Myel

NCT00296868 Prophylactic Administration of Vitamin C in Wrist Fractures

→ RSD (Reflex Sympathetic Dystrophy)|Algodystrophy|C

📊 Meta-Analyses

12 · systematic review

CRD42020203166 Hydrocortisone, ascorbic acid and thiamine for sepsis and septic shock: a meta-a

→ The effect of treatment with hydrocortisone, ascor

CRD42020207832 Combined treatment with ascorbic acid, hydrocortisone, and thiamine for patients

→ Sepsis rapidly progresses causing multiple organ d

CRD42020220135 Thiamine, ascorbic acid and hydrocortisone as metabolic resuscitation cocktail i

→ Septic shock, Sepsis, metabolic resuscitation

CRD42022296055 Comparisson of Hydrocortisone with Combined Hydrocortisone, Ascorbic Acid, and T

→ The adjuvant therapy of septic shock is not yet de

CRD42020167426 Lower-volume Polyethylene Glycol with Ascorbic Acid plus Adjunctive Drugs Prepar

→ Colonoscopy.Bowel preparation

CRD42018093372 The effect of ascorbic acid on chronic kidney disease-mineral and bone disorder

→ Hemodialysis. Chronic kidney disease mineral bone

CRD42018094222 The effects of ascorbic acid supplementation on muscle damage and musculoskeleta

→ Muscle damage and musculoskeletal function after p

CRD42018107781 The neuropsychiatric effects of ascorbic acid deficiency and scurvy: a systemati

→ It is generally assumed that vitamin C deficiency

CRD42019146826 Ascorbic Acid supplementation in Type 2 Diabetes Mellitus: A protocol for system

→ Diabetes Mellitus (DM) is a non-communicable disea

CRD42020170523 Efficacy of a combination therapy including Corticosteroids and Ascorbic acid an

→ sepsis/septic shock

CRD42020170825 The effect of Ascorbic Acid on sepsis patients: an meta-analysis of randomised c

→ We have made an meta-analysis that addressed that

CRD42020172525 The effect of Ascorbic Acid, Thiamine, Steroids on sepsis patients: an meta-anal

→ We have made an meta-analysis that addressed that

📚 PubMed References

12 · cited research

PMID 31476335 Ascorbic acid presents rapid behavioral and hippocampal synaptic plasticity effe

Prog Neuropsychopharmacol Biol Psychiatry

PMID 31656084 Ascorbic Acid 2-Glucoside Stably Promotes the Primitiveness of Embryonic and Mes

Antioxid Redox Signal

PMID 31911474 High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model

Proc Natl Acad Sci U S A

PMID 31926565 Attenuation of sleep deprivation dependent deterioration in male fertility param

Reprod Biol Endocrinol

PMID 31936891 Supporting Cell-Based Tendon Therapy: Effect of PDGF-BB and Ascorbic Acid on Rab

Int J Mol Sci

PMID 32013700 Vitamin C Intravenous Treatment In the Setting of Atrial Fibrillation Ablation:

J Am Heart Assoc

PMID 32102933 High-dose vitamin C enhances cancer immunotherapy

Sci Transl Med

PMID 32153415 Ascorbic Acid Sensitizes Colorectal Carcinoma to the Cytotoxicity of Arsenic Tri

Front Pharmacol

PMID 32184123 Ascorbic acid inhibits vascular remodeling induced by mental stress in overweigh

Life Sci

PMID 32203209 Decreased vitamin C uptake mediated by SLC2A3 promotes leukaemia progression and

Br J Cancer

PMID 32319585 PHLPP2 is a novel biomarker and epigenetic target for the treatment of vitamin C

Int J Oncol

PMID 32466098 Ascorbic Acid Promotes Functional Restoration after Spinal Cord Injury Partly by

Cells

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables