Relationship Graph Explorer

Follow the connections

Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

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Herb

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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Abetalipoproteinemia Abortion, Habitual Agenesis Acanthamoeba Keratitis Acanthosis Nigricans Achondrogenesis Achondroplasia Acne Vulgaris Acne Keloid Apert Syndrome

🏥 Disease / Health Topic

Osteoarthritis

Clinical Trials

Meta-Analyses

PubMed References

📋 Sample Trials

NCT02604381

A Study on the Efficacy of Glucosamine Sulfate Potassium Chloride/Standardized Ginkgo Biloba Leaf Extract in Adults With Osteoarthritis of the Knee.

Completed · Phase 2

NCT04765189

Evaluation of Mangoselect® in Improvement of Exercise/Activity-induced Knee Joint Discomfort in Subjects Suffering From Osteoarthritis Grade I or II

Completed

NCT03744611

Efficacy and Safety of Cortex Eucommiae (CE: Eucommia Ulmoides Oliver Extract) in Subjects With Mild Osteoarthritis

Completed

📊 Sample Meta-Analyses

CRD42015016920

The effectiveness of moxibustion for treating knee osteoarthritis: a systematic review and meta-analyses

Knee osteoarthritis is a major cause of pain and functional limitation. Compleme

CRD42015016920

The effectiveness of moxibustion for treating knee osteoarthritis: a systematic review and meta-analyses

Knee osteoarthritis is a major cause of pain and functional limitation. Compleme

CRD42015019793

Systematic review and meta-analyses of effectiveness and safety of Brazilian medicinal plants in the treatment of osteoarthritis: study protocol

Osteoarthritis affects 1% of world population and is the most common cause of mu

📚 Sample References

None linked yet.

🏥 All Disease / Health Topic data fields for Osteoarthritis

🏥 Names

Disease Name

Osteoarthritis

Topic Type

disease

🔍 Raw view — every non-empty column on this row (14 fields)

name

Osteoarthritis

topic type

disease

tcmsp disease id

586

🌿 Related Herbs

1 · contains this compound

Ephedra

Ma Huang

⚗️ Related Ingredients

18 · compounds in this herb

🧬 Gene / Protein Targets

5 · genes implicated in this disease

ALOX5

Gene ALOX5

Prostaglandin G/H synthase 2

Interstitial collagenase

Stromelysin-1

72 kDa type IV collagenase

📜 Related Formulas

1 · contains this herb

Zu Shi Ma Plaster

📋 Clinical Trials

12 · subject of clinical study

NCT02604381 A Study on the Efficacy of Glucosamine Sulfate Potassium Chloride/Standardized G

→ Osteoarthritis of the Knee

NCT04765189 Evaluation of Mangoselect® in Improvement of Exercise/Activity-induced Knee Join

→ Osteoarthritis, Knee

NCT03744611 Efficacy and Safety of Cortex Eucommiae (CE: Eucommia Ulmoides Oliver Extract) i

→ Osteoarthritis

NCT04607759 Clinical Trial on the Articular Pain With a Cucumber Supplement in Patients Diag

→ Osteoarthritis

NCT04483024 Effects of Chicken Extract and Collagen on Mobility

→ Knee Osteoarthritis|Muscle Loss

NCT03017118 Turmeric for Patients With Basal Joint Arthritis

→ Thumb Osteoarthritis

NCT00992004 Evaluation of the Efficacy of a Turmeric Extract (Arantal®) in Patients With Ost

→ Osteoarthritis, Knee

NCT02409381 Extract of Curcuma Longa Complexed With Phosphatidilcholine(Motore®)in the Treat

→ Osteoarthritis, Knee

NCT01380015 Efficacy of Spearmint Tea in Relieving Osteoarthritis of the Knee

→ Osteoarthritis of the Knee

NCT00503828 Derris Scandens Benth Extract VS Naproxen in Knee OA

→ Knee Osteoarthritis

NCT01472822 Efficacy of Omija (Schisandra Chinensis) Extract in Subjects With Knee Osteoarth

→ Mild Knee Osteoarthritis

NCT00670475 Comparative Study of Olive Oil With Piroxicam Gel in Osteoarthritis of the Knee

→ Osteoarthritis of the Knee

📊 Meta-Analyses

12 · systematic review

CRD42015016920 The effectiveness of moxibustion for treating knee osteoarthritis: a systematic

→ Knee osteoarthritis is a major cause of pain and f

CRD42015016920 The effectiveness of moxibustion for treating knee osteoarthritis: a systematic

→ Knee osteoarthritis is a major cause of pain and f

CRD42015019793 Systematic review and meta-analyses of effectiveness and safety of Brazilian med

→ Osteoarthritis affects 1% of world population and

CRD42015019793 Systematic review and meta-analyses of effectiveness and safety of Brazilian med

→ Osteoarthritis affects 1% of world population and

CRD42015019793 Systematic review and meta-analyses of effectiveness and safety of Brazilian med

→ Osteoarthritis affects 1% of world population and

CRD42015019793 Systematic review and meta-analyses of effectiveness and safety of Brazilian med

→ Osteoarthritis affects 1% of world population and

CRD42022370912 Effect of garlic supplementation on osteoarthritis: a systematic review and meta

→ The main areas of research are osteoarthritis

CRD42017058194 The effect of green tea on plasma leptin and ghrelin levels: a systematic review

→ Obesity is the most common health problem worldwid

CRD42013005274 Efficacy of homeopathic Arnica montana: a meta-analysis of the double-blind rand

→ Subcutaneous mechanical injuries, delayed onset mu

CRD42021239810 Effects of pomegranate (Punica granatum) on osteoarthritis: A systematic review

→ Osteoarthritis

CRD42016035254 Relative efficacy of topical non-steroidal anti-inflammatory drugs and topical c

→ Osteoarthritis is the most common joint disorder,

CRD42021278763 Comparative efficacy and safety of intraarticular injection of lidocaine and cap

→ Knee osteoarthritis（KOA）is a common chronic degene

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables