Relationship Graph Explorer

Follow the connections

Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

🌿

Herb

→

→

→

→

🧪

Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Lutein

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Lutein

Retinitis Pigmentosa 2 Macular Degeneration 2 Age-related Macular Degeneration 2 Age Related Maculopathy 2 Infant, Newborn, Diseases|Other Lipid Storage Disorders 1 Age Related Macular Degeneration|Cognition Disorders 1 Assessment of dietary intake is known to involve a number of 1 Healthy Subjects 1 Age Related Macular Degeneration 1 Age-related Macular Degeneration (AMD) is the leading cause 1 Healthy But Chronically Stressed 1 Vision, Entoptic 1

📋 Sample Trials

NCT00006202

Lutein for Age-Related Macular Degeneration

Completed · Phase 2

NCT00029289

Effects of Lutein in Retinitis Pigmentosa

Completed · Phase 1|Phase 2

NCT00121589

Lutein/Zeaxanthin and Omega-3 Supplementation in Persons Over Age 60

Completed · Phase 1

📊 Sample Meta-Analyses

CRD42020195957

The effects of lutein on brain in healthy older adults: a systematic review of randomized controlled trials and cohort studies.

Lutein, Carotenoids, xanthophyll, cognitive function, brain function, brain stru

CRD42015017368

Effects of lutein supplements for visual function among healthy people and patients with age-related macular degeneration: a systematic review

Visual impairment including age-related macular degeneration

CRD42016045942

Lutein and zeaxanthin for reducing morbidity and mortality in preterm infants [Cochrane Protocol]

The Cochrane Neonatal Group

📚 Sample References

PMID 31820335

Lutein reverses hyperglycemia-mediated blockage of Nrf2 translocation by modulating the activation of intracellular protein kinases in retinal pigment epithelial (ARPE-19) cells

J Cell Commun Signal · 2020

PMID 32710479

Lutein inhibits breast cancer cell growth by suppressing antioxidant and cell survival signals and induces apoptosis

J Cell Physiol · 2021

PMID 33529717

Lutein attenuates excessive lipid accumulation in differentiated 3T3-L1 cells and abdominal adipose tissue of rats by the SIRT1-mediated pathway

Int J Biochem Cell Biol · 2021

⚗️ All Ingredient data fields for Lutein

⚗️ Identity

Name

Lutein

Aliases / Synonyms

XANTHOPHYLL; 127-40-2; Bo-Xan; Vegetable lutein; all-trans-Lutein; Vegetable luteol; trans-Lutein; Lutein ester; Xantofyl

🧪 Chemistry

Molecular Weight

568.8860

LogP

10.4033

Drug-likeness

0.203

Oral Bioavailability

22.5870

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC1=C(C(CC(C1)O)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2C(=CC(CC2(C)C)O)C)C)C

Isomeric SMILES

CC1=C(C(C[C@@H](C1)O)(C)C)/C=C/C(=C/C=C/C(=C/C=C/C=C(\C)/C=C/C=C(\C)/C=C/[C@H]2C(=C[C@@H](CC2(C)C)O)C)/C)/C

InChIKey

KBPHJBAIARWVSC-RGZFRNHPSA-N

InChI

InChI=1S/C40H56O2/c1-29(17-13-19-31(3)21-23-37-33(5)25-35(41)27-39(37,7)8)15-11-12-16-30(2)18-14-20-32(4)22-24-38-34(6)26-36(42)28-40(38,9)10/h11-25,35-37,41-42H,26-28H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,29-15+,30-16+,31-19+,32-20+/t35-,36+,37-/m0/s1

🔗 External References

HERB DB

HBIN033793 ↗

PubChem CID

5281243 ↗

CAS Number

127-40-2 ↗

NPASS

NPC313179

HIT

C0744

TCMID

13119

TCMSP

MOL013377

🔍 Raw view — every non-empty column on this row (32 fields)

name

Lutein

common names

XANTHOPHYLL; 127-40-2; Bo-Xan; Vegetable lutein; all-trans-Lutein; Vegetable luteol; trans-Lutein; Lutein ester; Xantofyl

herb ingredient id

HBIN033793

canonical smiles

CC1=C(C(CC(C1)O)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2C(=CC(CC2(C)C)O)C)C)C

isomeric smiles

CC1=C(C(C[C@@H](C1)O)(C)C)/C=C/C(=C/C=C/C(=C/C=C/C=C(\C)/C=C/C=C(\C)/C=C/[C@H]2C(=C[C@@H](CC2(C)C)O)C)/C)/C

inchi

inchikey

KBPHJBAIARWVSC-RGZFRNHPSA-N

mol wt

568.8860

num h acceptors

num h donors

mol logp

10.4033

num rotatable bonds

drug likeness

0.203

ob score

22.5870

cas id

127-40-2

tcmid ingredient id

13119

tcmsp ingredient id

MOL013377

pubchem cid

5281243

npass id

NPC313179

hit id

C0744

🏥 Linked Health Topics

7 · studied for these conditions (text bridge)

Age Related Macular Degeneration

syndrome

Exudative Age-Related Macular Degeneration

syndrome

📋 Clinical Trials

12 · subject of clinical study

NCT00006202 Lutein for Age-Related Macular Degeneration

→ Macular Degeneration

NCT00029289 Effects of Lutein in Retinitis Pigmentosa

→ Retinitis Pigmentosa

NCT00121589 Lutein/Zeaxanthin and Omega-3 Supplementation in Persons Over Age 60

→ Macular Degeneration

NCT00672230 Dietary Lutein and the Retinopathy of Prematurity

→ Lactation

NCT00913406 Effect of Lutein in S-26 Gold On Growth And Safety

→ Healthy

NCT01528605 Effects of Lutein and Zeaxanthin Supplementation on Early Age-related Macular De

→ Age-related Macular Degeneration

NCT01534533 Effects of Lutein Supplementation on Subclinical Atherosclerosis

→ Carotid Atherosclerosis|Carotid Intimal Medial Thi

NCT01621789 Efficacy of Lutein, Zeaxanthine and Trypan Blue to Stain the Anterior Lens Capsu

→ Cataract

NCT01627977 Association of Lutein, Zeaxanthin and Brilliant Blue in Chromovitrectomy

→ Epiretinal Membrane|Macular Hole|Proliferative Dia

NCT01730898 Lutein Absorption in Healthy Adults

→ Healthy Subjects

NCT02200263 The Effects of Lutein and Zeaxanthin Supplementation on Vision in Patients With

→ Ocular Albinism (OA)|Oculocutaneous Albinism (OCA)

NCT02257801 Effects of Lutein on Learning and Memory in Chronically Stressed Subjects and in

→ Healthy But Chronically Stressed

📊 Meta-Analyses

10 · systematic review

CRD42020195957 The effects of lutein on brain in healthy older adults: a systematic review of r

→ Lutein, Carotenoids, xanthophyll, cognitive functi

CRD42015017368 Effects of lutein supplements for visual function among healthy people and patie

→ Visual impairment including age-related macular de

CRD42016045942 Lutein and zeaxanthin for reducing morbidity and mortality in preterm infants [C

→ The Cochrane Neonatal Group

CRD42016046749 Does dietary intake of lutein affect physical activity behavior in adults? A sys

→ This systematic review will focus on physical acti

CRD42019121381 Mechanistic insights into the effect of lutein on atherosclerosis, vascular dysf

→ Cardiovascular diseases (CVDs) are the main cause

CRD42020168592 The impact of nanoscale nutrient delivery systems on in vivo bioavailability of

CRD42020197594 Systematic review of the evidence on lutein/zeaxanthin intake and human macular

→ optimal ocular tissue health

CRD42023485956 Assessment of biological carotenoid levels as biomarkers of dietary intake: a sy

→ Assessment of dietary intake is known to involve a

CRD42023439052 The Neuropharmacological and clinical effects of Lutein: A systematic review

→ The systematic review focuses on neurodegenerative

CRD42023449079 Complex of Lutein and Zeaxanthin to prevent Age-related Macular Degeneration(AMD

→ Age-related Macular Degeneration (AMD) is the lead

📚 PubMed References

5 · cited research

PMID 31820335 Lutein reverses hyperglycemia-mediated blockage of Nrf2 translocation by modulat

J Cell Commun Signal

PMID 32710479 Lutein inhibits breast cancer cell growth by suppressing antioxidant and cell su

J Cell Physiol

PMID 33529717 Lutein attenuates excessive lipid accumulation in differentiated 3T3-L1 cells an

Int J Biochem Cell Biol

PMID 34077894 Lutein attenuates angiotensin II- induced cardiac remodeling by inhibiting AP-1/

Redox Biol

PMID 36086831 Lutein ameliorates high-fat diet-induced obesity, fatty liver, and glucose intol

Phytother Res

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables