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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Lycine

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Lycine

Healthy|Cardiovascular Diseases 2 Obesity|Dysglycemia 1 Blood Flow Restriction Training|Betaine Supplementation 1 Nonalcoholic Steatohepatitis 1 Arsenic Metabolites Measured in Urine 1 Men Carrying 2 Minor Alleles for Choline Dehydrogenase rs126 1 Insulin Sensitivity 1 Hyperoxaluria 1 Homocystinuria 1 Hepatitis C 1 Unipolar Depression 1 Supplementation|Sport 1

📋 Sample Trials

NCT00102843

Effect of Betaine and Folic Acid on Vascular Function in Healthy Humans

Completed

NCT00126347

Effect of Betaine, Serine and Folic Acid on Vascular Function in Healthy Volunteers

Completed

NCT00283387

Efficacy of Betaine for Reduction of Urine Oxalate in Patients With Type 1 Primary Hyperoxaluria

Completed · Phase 2

📊 Sample Meta-Analyses

None linked yet.

📚 Sample References

PMID 32418914

Role of betaine in inhibiting the induction of RNA Pol III gene transcription and cell growth caused by alcohol

Chem Biol Interact · 2020

PMID 32808060

Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE-/- mice

Eur J Nutr · 2021

PMID 34248992

Dietary Betaine Mitigates Hepatic Steatosis and Inflammation Induced by a High-Fat-Diet by Modulating the Sirt1/Srebp-1/Pparɑ Pathway in Juvenile Black Seabream ( Acanthopagrus schlegelii)

Front Immunol · 2021

⚗️ All Ingredient data fields for Lycine

⚗️ Identity

Name

Lycine

Aliases / Synonyms

betaine; 107-43-7; glycine betaine; oxyneurine; Trimethylglycine; Abromine; Trimethylglycocoll; Glycocoll betaine; Glycylbetaine

🧪 Chemistry

Molecular Weight

117.1480

LogP

-1.5575

Drug-likeness

0.41

H-Bond Acceptors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C[N+](C)(C)CC(=O)[O-]

Isomeric SMILES

C[N+](C)(C)CC(=O)[O-]

InChIKey

KWIUHFFTVRNATP-UHFFFAOYSA-N

InChI

InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3

🔗 External References

HERB DB

HBIN033911 ↗

PubChem CID

247 ↗

NPASS

NPC59650

HIT

C0107

TCMID

23713; 2318

TCM-ID

22658

🔍 Raw view — every non-empty column on this row (30 fields)

name

Lycine

common names

betaine; 107-43-7; glycine betaine; oxyneurine; Trimethylglycine; Abromine; Trimethylglycocoll; Glycocoll betaine; Glycylbetaine

herb ingredient id

HBIN033911

canonical smiles

C[N+](C)(C)CC(=O)[O-]

isomeric smiles

C[N+](C)(C)CC(=O)[O-]

inchi

InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3

inchikey

KWIUHFFTVRNATP-UHFFFAOYSA-N

mol wt

117.1480

num h acceptors

num h donors

mol logp

-1.5575

num rotatable bonds

drug likeness

0.41

tcmid ingredient id

23713; 2318

tcm id ingredient id

22658

pubchem cid

247

npass id

NPC59650

hit id

C0107

🏥 Linked Health Topics

8 · studied for these conditions (text bridge)

Overweight And Obesity

syndrome

Peroxisome Biogenesis Disorders

group

Nonalcoholic Steatohepatitis

syndrome

📋 Clinical Trials

12 · subject of clinical study

NCT00102843 Effect of Betaine and Folic Acid on Vascular Function in Healthy Humans

→ Healthy|Cardiovascular Diseases

NCT00126347 Effect of Betaine, Serine and Folic Acid on Vascular Function in Healthy Volunte

→ Healthy|Cardiovascular Diseases

NCT00283387 Efficacy of Betaine for Reduction of Urine Oxalate in Patients With Type 1 Prima

→ Hyperoxaluria

NCT00310336 Chronic Hepatitis C Non-Responder Study With AdoMet and Betaine

→ Hepatitis C

NCT01213719 Effects of Betaine Supplementation on Strength and Muscle Creatine Content

→ Healthy Subjects

NCT01749982 A Preliminary Study of Choline and Betaine Supplementation Among Adults Exposed

→ Arsenic Metabolites Measured in Urine

NCT01838941 Betaine and Peroxisome Biogenesis Disorders

→ Peroxisome Biogenesis Disorders

NCT01950039 Metabolic Effects of Betaine Supplementation

→ Obesity|Dysglycemia

NCT02122211 Choline Dehydrogenase and Sperm Function: Effects of Betaine

→ Men Carrying 2 Minor Alleles for Choline Dehydroge

NCT02404337 Betaine METABOLISM OF PATIENTS With Homocystinuria

→ Homocystinuria

NCT03702205 Betaine Effect in Speed-strength Athletes

→ Supplementation|Sport

NCT00226356 Natural Supplements for Unipolar Depression

→ Unipolar Depression

📚 PubMed References

6 · cited research

PMID 32418914 Role of betaine in inhibiting the induction of RNA Pol III gene transcription an

Chem Biol Interact

PMID 32808060 Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signa

Eur J Nutr

PMID 34248992 Dietary Betaine Mitigates Hepatic Steatosis and Inflammation Induced by a High-F

Front Immunol

PMID 34658862 Betaine Attenuates Osteoarthritis by Inhibiting Osteoclastogenesis and Angiogene

Front Pharmacol

PMID 35682942 Betaine Alleviates High-Fat Diet-Induced Disruptionof Hepatic Lipid and Iron Hom

Int J Mol Sci

PMID 36124652 One-year longitudinal association between changes in dietary choline or betaine

Am J Clin Nutr

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables