AlternativeMed
Ancient Wisdom Natural Remedies Modern Wellness
Relationship Graph Explorer

Follow the connections

Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

🌿
Herb
6,826
→
⚗️
Ingredient
44,595
→
🧬
Gene Target
15,505
→
🏥
Disease
30,170
→
🧪
Evidence
23,295
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases
Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins
⚗️ Ingredient

Lycopene

Open on HERB 2.0 ↗
27
Clinical Trials
31
Meta-Analyses
22
PubMed References
Top Conditions Studied with Lycopene
Prostate Cancer 7 Oral submucous fibrosis (OSF) is an insidious and chronic or 2 Oral Lichen Planus 2 Oral submucous fibrosis, first described by Schwartz is a ch 1 Intraepithelial Prostatic Neoplasia|Prostatic Neoplasms 1 Insulin-like Growth Factor-I (IGF-I) is a member of the IGF 1 Adenocarcinoma of the Prostate|Recurrent Prostate Cancer|Sta 1 Cancers are known as the second cause of death in developed 1 Oral submucous fibrosis (OSMF) is a chronic premalignant dis 1 Healthy, no Evidence of Disease|Prostate Cancer 1 In this review, we will study the effects of tomato and lyco 1 Adenocarcinoma of the Prostate 1
📋 Sample Trials
NCT01105338
Lycopene or Green Tea for Men at Risk of Prostate Cancer
Completed · Phase 2|Phase 3
NCT03460860
Astaxanthin (2 mg) + Lycopene (1.8 mg) + D-Alpha-Tocopherol (10 IU) For The Treatment Of Skin Aging
Completed
NCT02550483
Novel Metabolites of Beta-Carotene and Lycopene
Completed
📊 Sample Meta-Analyses
CRD42019159312
Anti-cancer Effects of lycopene in Animal Models of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
CRD42022384395
Effect of Lycopene on Oral Lichen Planus and its Comparison with Corticosteroids: A Systematic Review and Meta-Analysis
Lichen planus (LP) as an inflammatory disease have autoimmune nature (Canto et a
CRD42022334083
The effect of tomato and lycopene on clinical characteristics and molecular markers of UV-Induced SkinDeterioration: A systematic review and meta-analysis of intervention trials
The skin with excessive UVR exposure has chemical and biological changes, and th
📚 Sample References
PMID 32014502
Natural ingredients-derived antioxidants attenuate H2O2-induced oxidative stress and have chondroprotective effects on human osteoarthritic chondrocytes via Keap1/Nrf2 pathway
Free Radic Biol Med · 2020
PMID 31790829
Lycopene prevents the progression of lipotoxicity-induced nonalcoholic steatohepatitis by decreasing oxidative stress in mice
Free Radic Biol Med · 2019
PMID 21855911
The combination of Serenoa repens, selenium and lycopene is more effective than serenoa repens alone to prevent hormone dependent prostatic growth
J Urol · 2011
⚗️ All Ingredient data fields for Lycopene
⚗️ Identity
Name
Lycopene
Aliases / Synonyms
502-65-8; all-trans-Lycopene; Psi,psi-carotene; trans-Lycopene; Lycopene 7; lycored; Redivivo; Mexoryl SAQ; Tomat-O-Red
🧪 Chemistry
Molecular Weight
536.8880
LogP
12.9380
Drug-likeness
0.136
Rotatable Bonds
16
🔬 Structures
Canonical SMILES
CC(=CCCC(=CC=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC=C(C)CCC=C(C)C)C)C)C)C
Isomeric SMILES
CC(=CCC/C(=C/C=C/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C=C/C=C(/CCC=C(C)C)\C)\C)\C)/C)/C)/C)C
InChIKey
OAIJSZIZWZSQBC-GYZMGTAESA-N
InChI
InChI=1S/C40H56/c1-33(2)19-13-23-37(7)27-17-31-39(9)29-15-25-35(5)21-11-12-22-36(6)26-16-30-40(10)32-18-28-38(8)24-14-20-34(3)4/h11-12,15-22,25-32H,13-14,23-24H2,1-10H3/b12-11+,25-15+,26-16+,31-17+,32-18+,35-21+,36-22+,37-27+,38-28+,39-29+,40-30+
🔗 External References
HERB DB
HBIN033972 ↗
PubChem CID
446925 ↗
NPASS
NPC99088
HIT
C0200
SymMap
16376
TCMID
13205
TCM-ID
18481
🔍 Raw view — every non-empty column on this row (31 fields)
name
Lycopene
common names
502-65-8; all-trans-Lycopene; Psi,psi-carotene; trans-Lycopene; Lycopene 7; lycored; Redivivo; Mexoryl SAQ; Tomat-O-Red
herb ingredient id
HBIN033972
canonical smiles
CC(=CCCC(=CC=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC=C(C)CCC=C(C)C)C)C)C)C
isomeric smiles
CC(=CCC/C(=C/C=C/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C=C/C=C(/CCC=C(C)C)\C)\C)\C)/C)/C)/C)C
inchi
InChI=1S/C40H56/c1-33(2)19-13-23-37(7)27-17-31-39(9)29-15-25-35(5)21-11-12-22-36(6)26-16-30-40(10)32-18-28-38(8)24-14-20-34(3)4/h11-12,15-22,25-32H,13-14,23-24H2,1-10H3/b12-11+,25-15+,26-16+,31-17+,32-18+,35-21+,36-22+,37-27+,38-28+,39-29+,40-30+
inchikey
OAIJSZIZWZSQBC-GYZMGTAESA-N
mol wt
536.8880
num h acceptors
0
num h donors
0
mol logp
12.9380
num rotatable bonds
16
drug likeness
0.136
symmap mol id
16376
tcmid ingredient id
13205
tcm id ingredient id
18481
pubchem cid
446925
npass id
NPC99088
hit id
C0200

🏥 Linked Health Topics

2 · studied for these conditions (text bridge)
Lichen Planus, Oral
syndrome
Chronic Periodontitis
syndrome

📋 Clinical Trials

12 · subject of clinical study
NCT01105338 Lycopene or Green Tea for Men at Risk of Prostate Cancer
→ Prostate Cancer
NCT03460860 Astaxanthin (2 mg) + Lycopene (1.8 mg) + D-Alpha-Tocopherol (10 IU) For The Trea
→ Skin Aging|Wrinkles
NCT02550483 Novel Metabolites of Beta-Carotene and Lycopene
→ Healthy
NCT03492593 Lycopene and Beta-carotene Metabolism in the Digestive Tract of Healthy Men
→ Digestion Chambers|Stability and Metabolism of Car
NCT00006078 Lycopene In Preventing of Prostate Cancer
→ Prostate Cancer
NCT00042731 Isoflavones & Lycopene in Localized Prostate Ca:Prior to Radical Prostatectomy
→ Prostate Cancer
NCT00068731 Lycopene in Treating Patients With Metastatic Prostate Cancer
→ Prostate Cancer
NCT00093561 Lycopene in Preventing Prostate Cancer in Healthy Participants
→ Prostate Cancer
NCT00154843 A Clinical Study to Determine Factors Affecting Absorption and Serum Levels of L
→ BPH
NCT00178113 A Pilot Study of Lycopene Supplementation in Prostatic Intraepithelial Neoplasia
→ Prostatic Intraepithelial Neoplasia
NCT00402285 Lycopene or Omega-3 Fatty Acid Nutritional Supplements in Treating Patients With
→ Prostate Cancer
NCT00416325 Lycopene in Preventing Prostate Cancer in Patients Who Are at High Risk of Devel
→ Prostate Cancer

📊 Meta-Analyses

12 · systematic review
CRD42019159312 Anti-cancer Effects of lycopene in Animal Models of Hepatocellular Carcinoma: A
CRD42022384395 Effect of Lycopene on Oral Lichen Planus and its Comparison with Corticosteroids
→ Lichen planus (LP) as an inflammatory disease have
CRD42022334083 The effect of tomato and lycopene on clinical characteristics and molecular mark
→ The skin with excessive UVR exposure has chemical
CRD42022334175 Effects of Tomato and Lycopene Supplementation on Blood Lipids and Glycemic Cont
→ In this review, we will study the effects of tomat
CRD42022353725 The effect of lycopene on the improvement of oral lichen planus lesions and its
→ Oral lichen planus
CRD42015019407 Lycopene consumption and risk of colorectal cancer:a dose-response meta-analysis
→ In recent years,with the improvement of people's l
CRD42016042092 Tomato or lycopene supplementation on vascular risk factors: a systematic review
→ In this review we are interested in evaluating the
CRD42016049526 Tomato and lycopene and risk of cardiovascular disease: a systematic review and
→ In this review we are interested in evaluating the
CRD42020192960 Effect of lycopene intake on serum prostate specific antigen (PSA): a systematic
→ Prostate cancer is one of the most common types of
CRD42020198588 Efficacy of lycopene in the management of Oral Leukoplakia.
→ Oral leukoplakia is a potentially malignant disord
CRD42019144926 Efficacy of lycopene for management of oral submucous fibrosis (OSMF)
→ Oral submucous fibrosis (OSMF) is a chronic premal
CRD42020183587 Lycopene supplementation for Patients in Cancer Therapy: A Systematic Review of
→ Lycopene or tomato during chemotherapy/radiotherap

📚 PubMed References

12 · cited research
PMID 32014502 Natural ingredients-derived antioxidants attenuate H2O2-induced oxidative stress
Free Radic Biol Med
PMID 31790829 Lycopene prevents the progression of lipotoxicity-induced nonalcoholic steatohep
Free Radic Biol Med
PMID 21855911 The combination of Serenoa repens, selenium and lycopene is more effective than
J Urol
PMID 31978713 Lycopene attenuates body weight gain through induction of browning via regulatio
J Nutr Biochem
PMID 31996227 Lycopene and bone: an in vitro investigation and a pilot prospective clinical st
J Transl Med
PMID 32466161 Nutraceutical Effects of Lycopene in Experimental Varicocele: An "In Vivo" Model
Nutrients
PMID 32708354 Lycopene Protects against Smoking-Induced Lung Cancer by Inducing Base Excision
Antioxidants (Basel)
PMID 32810585 Lycopene ameliorates chronic stress-induced hippocampal injury and subsequent le
Food Chem Toxicol
PMID 33672594 Lycopene Inhibits Oxidative Stress-Mediated Inflammatory Responses in Ethanol/Pa
Int J Mol Sci
PMID 33960999 AQP2 as a target of lycopene protects against atrazine-induced renal ionic homeo
Food Funct
PMID 34138692 Inhibition effect of thymoquinone and lycopene compounds on glutathione reductas
J Biomol Struct Dyn
PMID 34378595 Lycopene modulates lipid metabolism in rats and their offspring under a high-fat
Food Funct
How relationships are computed
  • Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
  • Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
  • Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
  • Ingredient ↔ Target: empty — needs HERB_ingredient_target import
  • Target ↔ Disease: empty — needs HERB_target_disease import
  • Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables