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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Melatonin

Open on HERB 2.0 ↗

215

Clinical Trials

205

Meta-Analyses

PubMed References

Top Conditions Studied with Melatonin

Delirium 8 Postoperative Pain 5 Anxiety 4 Migraine 4 COVID-19 3 Breast Cancer 3 Hypertension 3 Sleep Disorders, Circadian Rhythm 2 Osteoporosis|Osteopenia 2 Epilepsy 2 Pain. 2 Postoperative Delirium 2

📋 Sample Trials

NCT00097474

Effects of Hydrocortisone, Melatonin, and Placebo on Jet Lag

Completed · Phase 2

NCT02639741

Preoperative Melatonin or Vitamin C Administration on Postoperative Analgesia

Completed · Phase 4

NCT04530539

The Effect of Melatonin and Vitamin C on COVID-19

Completed

📊 Sample Meta-Analyses

CRD42020207400

Use of melatonin in cisplatin-induced loss of primordial follicles in mice ovaries: systematic review

CRD42021276835

Can oral exogenous melatonin be a standard or adjunct treatment for patients with hypertension? A systematic review and meta-analysis

Hypertension

CRD42021236174

Exogenous melatonin for sleep disturbances in Parkinson`s disease: a systematic review with meta-analysis

Sleep disturbances in Parkinson`s disease

📚 Sample References

PMID 31605630

Melatonin attenuates epidermal growth factor-induced cathepsin S expression in ARPE-19 cells: Implications for proliferative vitreoretinopathy

J Pineal Res · 2020

PMID 31710386

Melatonin activates cell death programs for the suppression of uterine leiomyoma cell proliferation

J Pineal Res · 2020

PMID 31743484

Melatonin ameliorates SGLT2 inhibitor-induced diabetic ketoacidosis by inhibiting lipolysis and hepatic ketogenesis in type 2 diabetic mice

J Pineal Res · 2020

⚗️ All Ingredient data fields for Melatonin

⚗️ Identity

Name

Melatonin

Aliases / Synonyms

73-31-4; Melatonine; N-Acetyl-5-methoxytryptamine; Circadin; N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide; 5-Methoxy-N-acetyltryptamine; N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide; Melatol; Melovine

🧪 Chemistry

Molecular Weight

232.2830

LogP

1.8551

Drug-likeness

0.845

Oral Bioavailability

52.9610

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC(=O)NCCC1=CNC2=C1C=C(C=C2)OC

Isomeric SMILES

CC(=O)NCCC1=CNC2=C1C=C(C=C2)OC

InChIKey

DRLFMBDRBRZALE-UHFFFAOYSA-N

InChI

InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)

🔗 External References

HERB DB

HBIN034657 ↗

PubChem CID

896 ↗

CAS Number

73-31-4 ↗

NPASS

NPC307963

HIT

C0210

SymMap

3857

TCMSP

MOL001431

TCM-ID

14296

🔍 Raw view — every non-empty column on this row (33 fields)

name

Melatonin

common names

herb ingredient id

HBIN034657

canonical smiles

CC(=O)NCCC1=CNC2=C1C=C(C=C2)OC

isomeric smiles

CC(=O)NCCC1=CNC2=C1C=C(C=C2)OC

inchi

InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)

inchikey

DRLFMBDRBRZALE-UHFFFAOYSA-N

mol wt

232.2830

num h acceptors

num h donors

mol logp

1.8551

num rotatable bonds

drug likeness

0.845

ob score

52.9610

cas id

73-31-4

symmap mol id

3857

tcmsp ingredient id

MOL001431

tcm id ingredient id

14296

pubchem cid

896

npass id

NPC307963

hit id

C0210

🏥 Linked Health Topics

12 · studied for these conditions (text bridge)

Burning Mouth Syndrome

Fetal Growth Retardation

Sleep Initiation And Maintenance Disorders

syndrome

📋 Clinical Trials

12 · subject of clinical study

NCT00097474 Effects of Hydrocortisone, Melatonin, and Placebo on Jet Lag

→ Jet Lag

NCT02639741 Preoperative Melatonin or Vitamin C Administration on Postoperative Analgesia

→ Postoperative Pain

NCT04530539 The Effect of Melatonin and Vitamin C on COVID-19

→ Covid19|SARS-CoV Infection

NCT00000171 Study of Melatonin: Sleep Problems in Alzheimer's Disease

→ Alzheimer Disease|Dyssomnias

NCT00230737 Effects of Melatonin on Insomnia Symptoms in Older Adults

→ Sleep Initiation and Maintenance Disorders

NCT00238108 Melatonin Supplements for Improving Sleep in Individuals With Hypertension

→ Sleep Disorders|Hypertension

NCT00315926 Melatonin and Cardiac Outcome After Major Surgery

→ Aortic Aneurysm

NCT00388661 Melatonin and Quality of Life in Dialysis Patients

→ Sleep Problems|Haemodialysis

NCT00404456 The Efficacy of Melatonin in Sleep Problems of Hemodialysis and Peritoneal Dialy

→ Hemodialysis|Peritoneal Dialysis|Sleep Problems

NCT00512070 Melatonin Metabolism Abnormality in Patients With Schizophrenia or Schizoaffecti

→ Schizophrenia|Schizoaffective Disorder|Bipolar Dis

NCT00513357 Melatonin Versus Placebo and the Effect on Appetite in Advanced Cancer Patients

→ Gastrointestinal Cancer|Lung Cancer

NCT00649961 Melatonin As A Novel Neuroprotectant In Preterm Infants- Dosage Study

→ Premature Birth|Brain Injury

📊 Meta-Analyses

12 · systematic review

CRD42020207400 Use of melatonin in cisplatin-induced loss of primordial follicles in mice ovari

CRD42021276835 Can oral exogenous melatonin be a standard or adjunct treatment for patients wit

→ Hypertension

CRD42021236174 Exogenous melatonin for sleep disturbances in Parkinson`s disease: a systema

→ Sleep disturbances in Parkinson`s disease

CRD42020221060 Effects of long-term melatonin treatment on fasting plasma glucose, insulin, HbA

→ althy adults or adult patients with metabolic dise

CRD42021283962 Melatonin and ramelteon in the treatment of delirium - A systematic review

→ Delirium, defined as a disturbance of attention, a

CRD42020201910 Melatonin levels in periodontal disease vs health: A systematic review and meta-

→ periodontal disease which is an oral inflammatory

CRD42014015040 Pharmacokinetic parameters of melatonin in man: a systematic review

→ To provide an overview OF the current knowledge co

CRD42021292855 The effect of melatonin on Quality of life and symptoms in cancer patients durin

→ Melatonin and cancer patients

CRD42018099267 Efficacy of melatonin and melatonin receptor agonists in insomnia: an umbrella r

→ Insomnia is a common condition. Currently, cogniti

CRD42015017042 Pharmacokinetics of alternative administration routes of melatonin

→ Administration of melatonin through pathways such

CRD42016038258 Melatonin and melatonin agonists as adjuncts for sleep and sedation in critical

→ Patients with critical illness admitted to intensi

CRD42016039468 Melatonin versus placebo for Alzheimer’s disease: results from a meta-analysis o

→ Alzheimer’s disease (AD) is a neurodegenerative di

📚 PubMed References

12 · cited research

PMID 31605630 Melatonin attenuates epidermal growth factor-induced cathepsin S expression in A

J Pineal Res

PMID 31710386 Melatonin activates cell death programs for the suppression of uterine leiomyoma

J Pineal Res

PMID 31743484 Melatonin ameliorates SGLT2 inhibitor-induced diabetic ketoacidosis by inhibitin

J Pineal Res

PMID 31762195 Role of melatonin as an SIRT1 enhancer in chronic obstructive pulmonary disease

J Cell Mol Med

PMID 31863775 Effect of melatonin on T/B cell activation and immune regulation in pinealectomy

Life Sci

PMID 31867684 Melatonin modulates airway smooth muscle cell phenotype by targeting the STAT3/A

Cell Tissue Res

PMID 31900938 Melatonin up-regulates bone marrow mesenchymal stem cells osteogenic action but

Br J Pharmacol

PMID 32006470 Melatonin fine-tunes intracellular calcium signals and eliminates myocardial dam

Biochem Pharmacol

PMID 32052470 Melatonin enhances thrombopoiesis through ERK1/2 and Akt activation orchestrated

J Pineal Res

PMID 32053237 Induction of SIRT1 by melatonin improves alcohol-mediated oxidative liver injury

J Pineal Res

PMID 32061949 Melatonin alleviates progression of uterine endometrial cancer by suppressing es

Cancer Lett

PMID 32067945 Exogenous melatonin restrains neuroinflammation in high fat diet induced diabeti

Life Sci

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables