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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Menthol

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Menthol

Hypertension|Prehypertension 1 Acute Exercise|Heat Exposure 1 Surgical patients with perioperative fasting 1 Electronic Cigarette Use|Cigarette Use, Electronic|Tobacco U 1 Actinic Keratosis 1 Hospitalized patients with symptoms of thirst received eithe 1 Electronic Cigarette Use 1 Gastrointestinal (GI) endoscopy is a commonly used diagnosti 1 Dyspnea|Chronic Obstructive Pulmonary Disease 1 Chronic breathlessness is a feeling of breathing discomfort 1 Diabetic Peripheral Neuropathy 1 Tobacco Use Disorder 1

📋 Sample Trials

NCT02984072

Menthol for PDT Pain Relief

Completed · Phase 4

NCT02102100

The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users

Completed

NCT03626519

Effects of Menthol on Dyspnoea in COPD Patients

Completed

📊 Sample Meta-Analyses

CRD42016036654

Menthol versus non-menthol cigarette use and smoking initiation, cessation, and dependence: a systematic review

The behaviours of smoking initiation and progression to regular smoking, smoking

CRD42019119301

Menthol versus non-menthol cigarette use and smoking initiation, cessation, and dependence: an updated systematic review

The behaviors of smoking initiation and progression to regular smoking, smoking

CRD42019125034

Thermophysiological and cardiovascular effects of menthol during physical exercise

Thermophysiological and cardiovascular effects of menthol application in healthy

📚 Sample References

PMID 32728032

Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel

Nat Commun · 2020

PMID 34834317

The Use of Menthol in Skin Wound Healing-Anti-Inflammatory Potential, Antioxidant Defense System Stimulation and Increased Epithelialization

Pharmaceutics · 2021

PMID 35334439

Sauna-like conditions or menthol treatment reduce tau phosphorylation through mild hyperthermia

Neurobiol Aging · 2022

⚗️ All Ingredient data fields for Menthol

⚗️ Identity

Name

Menthol

Aliases / Synonyms

dl-Menthol; 1490-04-6; 2-Isopropyl-5-methylcyclohexanol; 15356-70-4; 89-78-1; Cyclohexanol, 5-methyl-2-(1-methylethyl)-; Menthyl alcohol; p-Menthan-3-ol; Mentholum

🧪 Chemistry

Molecular Weight

156.2690

LogP

2.4395

Drug-likeness

0.618

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC1CCC(C(C1)O)C(C)C

Isomeric SMILES

CC1CCC(C(C1)O)C(C)C

InChIKey

NOOLISFMXDJSKH-UHFFFAOYSA-N

InChI

InChI=1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3

🔗 External References

HERB DB

HBIN034745 ↗

PubChem CID

1254 ↗

CAS Number

1490-04-6 ↗

NPASS

NPC223468

TCMID

13767

TCMSP

MOL007330

TCM-ID

2761

🔍 Raw view — every non-empty column on this row (31 fields)

name

Menthol

common names

dl-Menthol; 1490-04-6; 2-Isopropyl-5-methylcyclohexanol; 15356-70-4; 89-78-1; Cyclohexanol, 5-methyl-2-(1-methylethyl)-; Menthyl alcohol; p-Menthan-3-ol; Mentholum

herb ingredient id

HBIN034745

canonical smiles

CC1CCC(C(C1)O)C(C)C

isomeric smiles

CC1CCC(C(C1)O)C(C)C

inchi

InChI=1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3

inchikey

NOOLISFMXDJSKH-UHFFFAOYSA-N

mol wt

156.2690

num h acceptors

num h donors

mol logp

2.4395

num rotatable bonds

drug likeness

0.618

cas id

1490-04-6

tcmid ingredient id

13767

tcmsp ingredient id

MOL007330

tcm id ingredient id

2761

pubchem cid

1254

npass id

NPC223468

🏥 Linked Health Topics

5 · studied for these conditions (text bridge)

Diabetic Peripheral Neuropathy

syndrome

📋 Clinical Trials

12 · subject of clinical study

NCT02984072 Menthol for PDT Pain Relief

→ Actinic Keratosis

NCT02102100 The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirabili

→ Nicotine Dependence

NCT03626519 Effects of Menthol on Dyspnoea in COPD Patients

→ Copd|Dyspnea|Lung Diseases

NCT03164668 Menthol Flavored E-cigarette Use During a Simulated Ban of Menthol Cigarettes

→ Tobacco Use Disorder

NCT02728687 Topical Menthol +/- Mannitol for Painful Diabetic Peripheral Neuropathy

→ Diabetic Peripheral Neuropathy

NCT01408446 Effects and Safety of Menthol on Blood Pressure and Metabolic Parameters in Preh

→ Hypertension|Prehypertension

NCT04879225 Menthol and Mint Experimental Tobacco Marketplace (ETM) Study

→ Cigarette Smoking|Vaping

NCT04900129 Inhalation of Vapor With Medication (Diclofenac Sodium, Menthol, Methyl Salicyla

→ Covid19

NCT02100670 A Multicenter Efficacy Study of a Diclofenac+Menthol Gel in Subjects With Ankle

→ Pain

NCT03095521 A Local Clinical Study for the Comparative Evaluation of Efficacy and Safety of

→ Sore Throat

NCT04677985 Analgesic Induces Similar Upper and Lower Body Pain Pressure Threshold Increases

→ Pain, Acute|Muscle Soreness|Tendon Injuries

NCT01329263 Smoking Topography and Harm Exposure in Menthol Cigarettes

→ Cigarette Smoking Toxicity

📊 Meta-Analyses

9 · systematic review

CRD42016036654 Menthol versus non-menthol cigarette use and smoking initiation, cessation, and

→ The behaviours of smoking initiation and progressi

CRD42019119301 Menthol versus non-menthol cigarette use and smoking initiation, cessation, and

→ The behaviors of smoking initiation and progressio

CRD42019125034 Thermophysiological and cardiovascular effects of menthol during physical exerci

→ Thermophysiological and cardiovascular effects of

CRD42020156087 The Impact of Menthol Cigarette Bans

→ The impact of menthol cigarette bans on tobacco us

CRD42020166841 Impact of non-menthol flavors in tobacco products on perception and use among yo

→ tobacco control

CRD42020171050 Effects of menthol on breathing sensations: A systematic review

→ Chronic breathlessness is a feeling of breathing d

CRD42022334990 Effects of menthol on thirst during surgery patients fasting: A meta-analysis

→ Surgical patients with perioperative fasting

CRD42023430941 Assessment of efficacy and safety of peppermint oil during gastrointestinal endo

→ Gastrointestinal (GI) endoscopy is a commonly used

CRD42023422753 The effectiveness of menthol oral stimuli in thirst relief in hospitalized patie

→ Hospitalized patients with symptoms of thirst rece

📚 PubMed References

6 · cited research

PMID 32728032 Molecular mechanisms underlying menthol binding and activation of TRPM8 ion chan

Nat Commun

PMID 34834317 The Use of Menthol in Skin Wound Healing-Anti-Inflammatory Potential, Antioxidan

Pharmaceutics

PMID 35334439 Sauna-like conditions or menthol treatment reduce tau phosphorylation through mi

Neurobiol Aging

PMID 35682765 Effect of Skin Ion Channel TRPM8 Activation by Cold and Menthol on Thermoregulat

Int J Mol Sci

PMID 35814769 The Severity of Acute Kidney and Lung Injuries Induced by Cecal Ligation and Pun

Front Med (Lausanne)

PMID 36120368 Protective effects of menthol against sepsis-induced hepatic injury: Role of med

Front Pharmacol

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables