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Relationship Graph Explorer

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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

🌿
Herb
6,826
→
⚗️
Ingredient
44,598
→
🧬
Gene Target
15,695
→
🏥
Disease
30,467
→
🧪
Evidence
23,295
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases
Quick picks: A1BG A2M NAT1 NAT2 SERPINA3 AADAC AAMP AANAT AARS1 ABAT
🧬 Gene Target

MAPK8

Open on HERB 2.0 ↗
0
Clinical Trials
0
Meta-Analyses
7
PubMed References
📋 Sample Trials
None linked yet.
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 27171279
SESN2/sestrin 2 induction-mediated autophagy and inhibitory effect of isorhapontigenin (ISO) on human bladder cancers
Autophagy · 2016
PMID 35860733
Network Pharmacology-Based Prediction and Pharmacological Validation of Effects of Astragali Radix on Acetaminophen-Induced Liver Injury
Front Med (Lausanne) · 2022
PMID 33192531
Amygdalin Attenuates Atherosclerosis and Plays an Anti-Inflammatory Role in ApoE Knock-Out Mice and Bone Marrow-Derived Macrophages
Front Pharmacol · 2020
🧬 All Gene Target data fields for MAPK8
🧬 Identity
Gene Symbol
MAPK8
Gene Aliases
JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c
Protein Name
mitogen-activated protein kinase 8
Gene Type
protein-coding
TTD Target Type
Clinical Trial target
📍 Location
Organism
Homo sapiens
Taxonomy ID
9606
Chromosome
10
Map Location
10q11.22
🔗 External References
HERB DB
HBTAR003197 ↗
Entrez
5599 ↗
OMIM
601158 ↗
HGNC
6881 ↗
Ensembl
ENSG00000107643 ↗
TTD
T40097
🔍 Raw view — every non-empty column on this row (28 fields)
name
MAPK8
gene symbol
MAPK8
gene alias name
JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c
protein name
mitogen-activated protein kinase 8
type of gene
protein-coding
ttd target type
Clinical Trial target
organism
Homo sapiens
taxonomy id
9606
map location
10q11.22
chromosome
10
entrez id
5599
omim id
601158
hgnc id
6881
ensembl id
ENSG00000107643
ttd id
T40097
target id str
HBTAR003197
tcmsp target id
704

🌿 Related Herbs

1 · contains this compound
Ephedra
Ma Huang

⚗️ Related Ingredients

1 · compounds in this herb
Kaempferol
PubChem CID 5280863

🏥 Linked Health Topics

6 · diseases via target pathways
Insulin Resistance
phenotype
Obesity
syndrome
Hearing Loss
phenotype
Cancer, unspecific
disease
Inflammatory Disorders, Unspecified
disease
Crohns's Disease, unspecified
disease

📚 PubMed References

7 · cited research
PMID 27171279 SESN2/sestrin 2 induction-mediated autophagy and inhibitory effect of isorhapont
Autophagy
PMID 35860733 Network Pharmacology-Based Prediction and Pharmacological Validation of Effects
Front Med (Lausanne)
PMID 33192531 Amygdalin Attenuates Atherosclerosis and Plays an Anti-Inflammatory Role in ApoE
Front Pharmacol
PMID 34054546 Therapeutic Effects of Naringin in Rheumatoid Arthritis: Network Pharmacology an
Front Pharmacol
PMID 34813895 Investigation on the antitumor effects of paeonol against renal cell carcinoma b
J Ethnopharmacol
PMID 35237157 An Integrated Pharmacology-Based Strategy to Investigate the Potential Mechanism
Front Pharmacol
PMID 35483559 Zuogui Wan slowed senescence of bone marrow mesenchymal stem cells by suppressin
J Ethnopharmacol
How relationships are computed
  • Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
  • Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
  • Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
  • Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
  • Target ↔ Disease: ACTIVE — direct link via target_health_topics
  • Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables