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Ingredient
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Gene Target
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Disease
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Evidence
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trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
⚗️ Ingredient
Milrinone
2
Clinical Trials
16
Meta-Analyses
0
PubMed References
Top Conditions Studied with Milrinone
Septic shock, characterized by a high incidence and mortalit 1
Mitral Valve Replacement|Pulmonary Hypertension|Inhaled Milr 1
Pulmonary hypertension in cardiac surgery 1
Ischemic Heart Disease|Valvular Heart Disease 1
Progressive right ventricle (RV) dysfunction, cardiomyopathi 1
Probable transitional circulatory shock (as defined by the a 1
Persistent pulmonary hypertension of newborn(PPHN) is critic 1
Perioperative care 1
Outcomes associated with milrinone versus dobutamine usage i 1
The use of outpatient inotropes in the US has increased subs 1
Cerebral vasospasm after subarachnoid haemorrhage 1
The use of milrinone in children with heart failure is a rel 1
📋 Sample Trials
NCT06077721
Milrinone on Right Ventricular Strain in Cardiac Surgery
Recruiting
NCT05838846
Inhaled Versus Intravenous Milrinone for Patients Undergoing Mitral Valve Replacement Surgery
Active_Not_Recruiting · Phase 2|Phase 3
📊 Sample Meta-Analyses
CRD42016053009
Efficacy of milrinone over dobutamine in heterogeneous population of critically ill adult patients
Severe heart failure, Cardiogenic shock, Low cardiac output state (LCOS), Acute
CRD42022315003
Milrinone and Current therapeutic agents vs. Nimodipine for the prevention of cerebral vasospasm in hospitalised adults with aneurysmal and traumatic subarachnoid haemorrhage: A meta-analysis of RCTs and Observational studies
Cerebral vasospasm after subarachnoid haemorrhage
CRD42014009061
Milrinone for cardiac support: a systematic review of randomised clinical trials with meta-analyses and trial sequential analyses
📚 Sample References
None linked yet.
⚗️ All Ingredient data fields for Milrinone
⚗️ Identity
Name
Milrinone
Aliases / Synonyms
78415-72-2; Primacor; Milrinonum; Milrila; Milrinona; Milrinonum [Latin]; Win-47203-2; 6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridine-3-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile
🧪 Chemistry
Molecular Weight
211.2240
LogP
1.6170
Drug-likeness
0.779
H-Bond Acceptors
3
H-Bond Donors
1
Rotatable Bonds
1
🔬 Structures
Canonical SMILES
CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2
Isomeric SMILES
CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2
InChIKey
PZRHRDRVRGEVNW-UHFFFAOYSA-N
InChI
InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
🔗 External References
🔍 Raw view — every non-empty column on this row (27 fields)
name
Milrinone
common names
78415-72-2; Primacor; Milrinonum; Milrila; Milrinona; Milrinonum [Latin]; Win-47203-2; 6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridine-3-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile
herb ingredient id
HBIN035536
canonical smiles
CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2
isomeric smiles
CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2
inchi
InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
inchikey
PZRHRDRVRGEVNW-UHFFFAOYSA-N
mol wt
211.2240
num h acceptors
3
num h donors
1
mol logp
1.6170
num rotatable bonds
1
drug likeness
0.779
tcm id ingredient id
13304
pubchem cid
4197
📋 Clinical Trials
2 · subject of clinical studyNCT06077721 Milrinone on Right Ventricular Strain in Cardiac Surgery
→ Ischemic Heart Disease|Valvular Heart Disease
NCT05838846 Inhaled Versus Intravenous Milrinone for Patients Undergoing Mitral Valve Replac
→ Mitral Valve Replacement|Pulmonary Hypertension|In
📊 Meta-Analyses
12 · systematic reviewCRD42016053009 Efficacy of milrinone over dobutamine in heterogeneous population of critically
→ Severe heart failure, Cardiogenic shock, Low cardi
CRD42022315003 Milrinone and Current therapeutic agents vs. Nimodipine for the prevention of ce
→ Cerebral vasospasm after subarachnoid haemorrhage
CRD42014009061 Milrinone for cardiac support: a systematic review of randomised clinical trials
CRD42023391534 The effects of milrinone on patients undergoing coronary artery bypass: a system
→ Perioperative care
CRD42022316325 Comparison of milrinone to dobutamine in patients undergoing cardiac surgery: a
→ Outcomes associated with milrinone versus dobutami
CRD42022303597 Efficacy of Levosimendan, Milrinone, and Dobutamine in Patients with Right Heart
→ Progressive right ventricle (RV) dysfunction, card
CRD42022329709 The effect of intravenous milrinone in adult patients with cardiac dysfunction
→ Cardiac dysfunction is a life-threatening organ ma
CRD42022334045 Mortality prognosis of Chronic Dobutamine vs Milrinone Infusions for end-stage h
→ The use of outpatient inotropes in the US has incr
CRD42021267784 Milrinone for vasospasm in subarachnoid hemorrhage: Systematic review and meta-a
→ Aneurysmal subarachnoid hemorrhage (aSAH) represen
CRD42023446535 Treatment of preterm neonates with probable transitional circulatory shock: A sy
→ Probable transitional circulatory shock (as define
CRD42023321041 Pulmonary Vasodilator drugs in Cardiac Surgery: a Systematic Review with Bayesia
→ Pulmonary hypertension in cardiac surgery
CRD42023409644 Efficacy and safety of sildenafil combined with milrinone in the treatment of PP
→ Sildenafil is essential for the treatment of PPHN
How relationships are computed
- Clinical Trials / Meta-Analyses / References: direct foreign-key link via
subject_entity_id(Phase 2d wireup) - Formula ↔ Herbs: text bridge via
formulas.herbs_in_pinyinmatchingherbs.pinyin_name - Herb ↔ Ingredient:
ACTIVE — direct link via
herb_ingredients - Ingredient ↔ Target:
ACTIVE — direct link via
ingredient_targets - Target ↔ Disease:
ACTIVE — direct link via
target_health_topics - Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables