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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Morphine

Open on HERB 2.0 ↗

278

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Morphine

Postoperative Pain 20 Pain 20 Acute Pain 8 Post Operative Pain 8 Pain, Postoperative 4 Renal Colic 4 Neonatal Abstinence Syndrome 3 Post-Operative Pain 3 Opioid Use Disorder 3 Acute Myocardial Infarction 3 Healthy 3 Analgesia 3

📋 Sample Trials

NCT00921102

Atropine to Prevent Nausea and Vomiting After Spinal Anesthesia for Caesarean Section

Completed · Phase 4

NCT00004390

Phase III Randomized Controlled Study of Morphine and Nortriptyline in the Management of Postherpetic Neuralgia

Completed · Phase 3

NCT00004696

Study of Morphine in Postoperative Infants to Allow Normal Ventilation

Completed

📊 Sample Meta-Analyses

CRD42015018975

Impact of morphine, fentanyl, oxycodone or codeine on patient consciousness, appetite and thirst when used to treat cancer pain [Cochrane Protocol]

The Cochrane Pain, Palliative and Supportive Care Group

CRD42015024937

Topical morphine versus local anaesthetic for the management of oral mucositis among patients with head and neck cancer undergoing treatment: a systematic review

Head and neck cancers include cancers of the mouth, tongue, salivary glands and

CRD42015026190

Morphine for neuropathic pain in adults [Cochrane Protocol]

The Cochrane Pain, Palliative and Supportive Care Group

📚 Sample References

PMID 31413370

Morphine coordinates SST and PV interneurons in the prelimbic cortex to disinhibit pyramidal neurons and enhance reward

Mol Psychiatry · 2021

PMID 31626971

Morphine decreases the function of primary human natural killer cells by both TLR4 and opioid receptor signaling

Brain Behav Immun · 2020

PMID 31751616

Epigenetic upregulation of hippocampal CXCL12 contributes to context spatial memory-associated morphine conditioning

Brain Behav Immun · 2020

⚗️ All Ingredient data fields for Morphine

⚗️ Identity

Name

Morphine

Aliases / Synonyms

Morphia; Morphium; Morphin; Morphinum; (-)-Morphine; Morphina; Ospalivina; Duromorph; 57-27-2

🧪 Chemistry

Molecular Weight

285.3430

LogP

1.1981

Drug-likeness

0.703

Oral Bioavailability

24.6940

H-Bond Acceptors

H-Bond Donors

🔬 Structures

Canonical SMILES

CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O

Isomeric SMILES

CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3[C@H](C=C4)O

InChIKey

BQJCRHHNABKAKU-KBQPJGBKSA-N

InChI

InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1

🔗 External References

HERB DB

HBIN035767 ↗

PubChem CID

5288826 ↗

CAS Number

57-27-2 ↗

NPASS

NPC232533

HIT

C0226

SymMap

256

TCMID

14973

TCMSP

MOL006979

TCM-ID

2544

🔍 Raw view — every non-empty column on this row (34 fields)

name

Morphine

common names

Morphia; Morphium; Morphin; Morphinum; (-)-Morphine; Morphina; Ospalivina; Duromorph; 57-27-2

herb ingredient id

HBIN035767

canonical smiles

CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O

isomeric smiles

CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3[C@H](C=C4)O

inchi

InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1

inchikey

BQJCRHHNABKAKU-KBQPJGBKSA-N

mol wt

285.3430

num h acceptors

num h donors

mol logp

1.1981

num rotatable bonds

drug likeness

0.703

ob score

24.6940

cas id

57-27-2

symmap mol id

256

tcmid ingredient id

14973

tcmsp ingredient id

MOL006979

tcm id ingredient id

2544

pubchem cid

5288826

npass id

NPC232533

hit id

C0226

🏥 Linked Health Topics

12 · studied for these conditions (text bridge)

Neonatal Abstinence Syndrome

Postoperative Complications

group

Prostatic Neoplasms

group

📋 Clinical Trials

12 · subject of clinical study

NCT00921102 Atropine to Prevent Nausea and Vomiting After Spinal Anesthesia for Caesarean Se

→ Cesarean Section|Anesthesia,Spinal|Postoperative N

NCT00004390 Phase III Randomized Controlled Study of Morphine and Nortriptyline in the Manag

→ Pain|Herpes Zoster

NCT00004696 Study of Morphine in Postoperative Infants to Allow Normal Ventilation

→ Infant, Newborn, Diseases|Pain

NCT00125684 Bioavailability and Effectiveness of Transdermally Administered Morphine

→ Cancer|Pain

NCT00142519 Comparison of A Single Dose Combination of Methadone and Morphine With Morphine

→ Pain

NCT00195910 Safety and Efficacy Study of Hydromorphone and Morphine

→ Pain

NCT00237731 Pre-hospital Morphine Titration : Comparison of 0,05 Versus 0,1 mg/kg

→ Severe, Acute Pain in a Pre-hospital Setting

NCT00293969 A Trial Comparing Different Dosing Regimens of Morphine in Patients With Moderat

→ Pain

NCT00305058 Trial Comparing Morphine to Hydromorphone in Elderly Patients With Severe Pain

→ Acute Pain

NCT00357942 Topical Morphine for Stomatitis-related Pain Induced by Chemotherapy

→ Pain|Mucositis

NCT00374881 A Study of the Safety and Efficacy of Combination Therapy With Morphine, Phenyle

→ Acute Pain

NCT00385541 Comparison of Side Effects of Morphine and Hydromorphone Patient-Controlled Anal

→ Post Operative Pain

📊 Meta-Analyses

12 · systematic review

CRD42015018975 Impact of morphine, fentanyl, oxycodone or codeine on patient consciousness, app

→ The Cochrane Pain, Palliative and Supportive Care

CRD42015024937 Topical morphine versus local anaesthetic for the management of oral mucositis a

→ Head and neck cancers include cancers of the mouth

CRD42015026190 Morphine for neuropathic pain in adults [Cochrane Protocol]

→ The Cochrane Pain, Palliative and Supportive Care

CRD42016044075 Effectiveness and safety of fentanyl and morphine added to intrathecal bupivacai

→ Patients coming for caesarean section generally un

CRD42017060656 The efficacy and safety of morphine for analgesia in patients with presumed isch

→ Acute coronary syndrome is a leading cause of prem

CRD42017074922 Neuraxial morphine and diamorphine after cesarean delivery: a systematic review

→ Respiratory depression.

CRD42018090782 A systematic review and meta-analysis of slow-release oral morphine as a mainten

→ Slow-acting oral morphine as maintenance therapy f

CRD42018093243 Effectiveness and safety of morphine for patients with acute myocardial infarcti

→ Cardiovascular diseases are the major cause of mor

CRD42018100613 Effects of preoperative intrathecal morphine on postoperative intravenous morphi

→ Postoperative pain is a major concern of anesthesi

CRD42018106091 Safety of using morphine in acute decompensated heart failure: a systematic revi

→ One of the most common diseases in emergency depar

CRD42018108375 Medications for the prevention of pruritus in women undergoing cesarean delivery

→ Approximately 72% of obstetric patients having IT

CRD42019117374 Association of morphine analgesia on clinical outcomes in ST-elevation myocardia

→ ST elevation myocardial infarction

📚 PubMed References

12 · cited research

PMID 31413370 Morphine coordinates SST and PV interneurons in the prelimbic cortex to disinhib

Mol Psychiatry

PMID 31626971 Morphine decreases the function of primary human natural killer cells by both TL

Brain Behav Immun

PMID 31751616 Epigenetic upregulation of hippocampal CXCL12 contributes to context spatial mem

Brain Behav Immun

PMID 31989355 Pellino1 Contributes to Morphine Tolerance by Microglia Activation via MAPK Sign

Cell Mol Neurobiol

PMID 32187535 Morphine and Naloxone Facilitate Neural Stem Cells Proliferation via a TET1-Depe

Cell Rep

PMID 32524520 Morphine Induces Apoptosis, Inflammation, and Mitochondrial Oxidative Stress via

Mol Neurobiol

PMID 32926257 Morphine and Fentanyl Repeated Administration Induces Different Levels of NLRP3-

Cell Mol Neurobiol

PMID 33027625 NPY alterations induced by chronic morphine exposure affect the maintenance and

Neuropharmacology

PMID 34142718 Acute morphine blocks spinal respiratory motor plasticity via long-latency mecha

J Physiol

PMID 34260958 Activation of the spinal EGFR signaling pathway in a rat model of cancer-induced

Neuropharmacology

PMID 34527417 Astrocytes & Astrocyte derived Extracellular Vesicles in Morphine Induced Amyloi

Aging Dis

PMID 34678470 Spinal γ-Aminobutyric Acid Interneuron Plasticity Is Involved in the Reduced Ana

J Pain

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables