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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Mtl

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Mtl

Cystic Fibrosis 8 Asthma 7 Bronchiectasis 3 Pain 2 Amount of Pulpal anaesthesia 1 Brain Tumor|Tumor, Brain|Brain Neoplasm|Neoplasm, Supratento 1 Irreversible Pulpitis 1 Anaplastic Oligoastrocytoma|Anaplastic Oligodendroglioma|Mix 1 Perioperative care 1 Cough|Bronchial Hyperreactivity 1 Supratentorial Tumors 1 Brain Tumor|Intracranial Pressure 1

📋 Sample Trials

NCT02728687

Topical Menthol +/- Mannitol for Painful Diabetic Peripheral Neuropathy

Completed · Phase 1|Phase 2

NCT02760862

Comparative Study Between Hydrocortisone and Mannitol in Treatment of Postdural Puncture Headache

Completed · Phase 4

NCT00117208

Comparison of Inhaled Mannitol and rhDNase in Children With Cystic Fibrosis

Completed · Phase 2

📊 Sample Meta-Analyses

CRD42020156824

The use of mannitol to prevent cisplatin-induced nephrotoxicity: A systematic review

Cisplatin is a chemotherapeutic agent widely used for various types of tumor. Ho

CRD42021253990

Protective effect of mannitol on cisplatin-induced nephrotoxicity：a systematic review and meta-analysis

Cisplatin is a basic and widely used chemotherapeutic agent used in the treatmen

CRD42022324278

The use of mannitol for acute intracranial hypertension in a pediatric population.

The treatment of acute intracranial hypertension in a pediatric population with

📚 Sample References

None linked yet.

⚗️ All Ingredient data fields for Mtl

⚗️ Identity

Name

Mtl

Aliases / Synonyms

D-mannitol; mannitol; 69-65-8; Mannite; Osmitrol; Manna sugar; Cordycepic acid; Osmofundin; Resectisol; Diosmol

🧪 Chemistry

Molecular Weight

182.1720

LogP

-3.5854

Drug-likeness

0.261

Oral Bioavailability

17.7350

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C(C(C(C(C(CO)O)O)O)O)O

Isomeric SMILES

C([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O

InChIKey

FBPFZTCFMRRESA-KVTDHHQDSA-N

InChI

InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1

🔗 External References

HERB DB

HBIN035817 ↗

PubChem CID

6251 ↗

CAS Number

133-43-7 ↗

NPASS

NPC86412

HIT

C0206

TCMID

13497

TCMSP

MOL000003

TCM-ID

10541

🔍 Raw view — every non-empty column on this row (33 fields)

name

Mtl

common names

D-mannitol; mannitol; 69-65-8; Mannite; Osmitrol; Manna sugar; Cordycepic acid; Osmofundin; Resectisol; Diosmol

herb ingredient id

HBIN035817

canonical smiles

C(C(C(C(C(CO)O)O)O)O)O

isomeric smiles

C([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O

inchi

InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1

inchikey

FBPFZTCFMRRESA-KVTDHHQDSA-N

mol wt

182.1720

num h acceptors

num h donors

mol logp

-3.5854

num rotatable bonds

drug likeness

0.261

ob score

17.7350

cas id

133-43-7

tcmid ingredient id

13497

tcmsp ingredient id

MOL000003

tcm id ingredient id

10541

pubchem cid

6251

npass id

NPC86412

hit id

C0206

🏥 Linked Health Topics

10 · studied for these conditions (text bridge)

Intracranial Hypertension

disease

Irreversible Pulpitis

syndrome

Diabetic Peripheral Neuropathy

syndrome

Brain Edema

phenotype

📋 Clinical Trials

12 · subject of clinical study

NCT02728687 Topical Menthol +/- Mannitol for Painful Diabetic Peripheral Neuropathy

→ Diabetic Peripheral Neuropathy

NCT02760862 Comparative Study Between Hydrocortisone and Mannitol in Treatment of Postdural

→ Headache

NCT00117208 Comparison of Inhaled Mannitol and rhDNase in Children With Cystic Fibrosis

→ Cystic Fibrosis

NCT00199511 Hypertonic Saline 75% vs Mannitol 20%

→ Brain Tumor|Tumor, Brain|Brain Neoplasm|Neoplasm,

NCT00251056 Mannitol Dose Response Study in Cystic Fibrosis

→ Cystic Fibrosis

NCT00293475 Methotrexate, Mannitol, Rituximab, and Carboplatin in Treating Patients With New

→ Central Nervous System Lymphoma

NCT00303849 Carboplatin, Melphalan, Etoposide Phosphate, Mannitol, and Sodium Thiosulfate in

→ Anaplastic Oligoastrocytoma|Anaplastic Oligodendro

NCT00446771 A Pharmacokinetic and Bioavailability Study of Mannitol for Inhalation Using Nor

→ Healthy Volunteers

NCT00447018 Mannitol Versus Hypertonic Saline Solution in the Treatment of Elevated Intracra

→ Intracranial Hypertension

NCT00585260 Mannitol Bronchoprovocation Challenge Ancillary Study/ACRN

→ Asthma

NCT00730977 A Pilot Study to Investigate Administration of Mannitol Via a Novel Dry Powder I

→ Healthy|Bronchiectasis

NCT00792714 Pharmacokinetics of Inhaled Mannitol in Cystic Fibrosis Patients

→ Cystic Fibrosis

📊 Meta-Analyses

12 · systematic review

CRD42020156824 The use of mannitol to prevent cisplatin-induced nephrotoxicity: A systematic re

→ Cisplatin is a chemotherapeutic agent widely used

CRD42021253990 Protective effect of mannitol on cisplatin-induced nephrotoxicity：a syste

→ Cisplatin is a basic and widely used chemotherapeu

CRD42022324278 The use of mannitol for acute intracranial hypertension in a pediatric populatio

→ The treatment of acute intracranial hypertension i

CRD42022316298 To evaluate hypertonic saline solution treatment versus mannitol for elevated in

→ Increased intracranial pressure in secondary brain

CRD42020151300 Perioperative use of intravenous mannitol in partial nephrectomy

→ Mannitol is often used perioperatively in partial

CRD42020218252 Comparison of the effects of 3% hypertonic saline and 20% mannitol in patients u

→ One of the important goals of anaesthetic manageme

CRD42021275904 Hypertonic saline and mannitol in patients with Increased Intracranial Pressure

→ Increased ICP after stroke, including ischemic str

CRD42017077085 Anesthetic efficacy of mannitol plus lidocaine with epinephrine in inferior alve

→ Amount of Pulpal anaesthesia

CRD42018087213 The clinical efficacy of different doses of mannitol on patients with brain edem

→ This topic has been explored with many RCTs, but n

CRD42018099086 Mannitol for the prevention of perioperative acute kidney injury

→ Perioperative acute kidney injury (AKI).

CRD42023438827 Accuracy of bronchial challenge testing with mannitol for diagnosis of asthma

→ Asthma

CRD42023422580 Impact of Osmotic Diuresis Induced by Mannitol vs Hypertonic Saline in Intracran

→ neurosurgery(craniotomy) for cerebral tumors , cer

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables