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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Naringenin

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

📋 Sample Trials

None linked yet.

📊 Sample Meta-Analyses

None linked yet.

📚 Sample References

PMID 31758699

Naringenin attenuates non-alcoholic fatty liver disease by down-regulating the NLRP3/NF-κB pathway in mice

Br J Pharmacol · 2019

PMID 30527894

Naringenin targets on astroglial Nrf2 to support dopaminergic neurons

Pharmacol Res · 2019

PMID 21748601

Naringenin reduces lung metastasis in a breast cancer resection model

Protein Cell · 2011

⚗️ All Ingredient data fields for Naringenin

⚗️ Identity

Name

Naringenin

Aliases / Synonyms

480-41-1; (S)-Naringenin; salipurpol; Naringenine; Salipurol; (S)-5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one; (2S)-Naringenin; pelargidanon; naringetol

🧪 Chemistry

Molecular Weight

272.2560

LogP

2.5099

Drug-likeness

0.742

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC=C(C=C3)O

Isomeric SMILES

C1[C@H](OC2=CC(=CC(=C2C1=O)O)O)C3=CC=C(C=C3)O

InChIKey

FTVWIRXFELQLPI-ZDUSSCGKSA-N

InChI

InChI=1S/C15H12O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-6,13,16-18H,7H2/t13-/m0/s1

🔗 External References

HERB DB

HBIN036366 ↗

PubChem CID

439246 ↗

CAS Number

67604-48-2; 480-41-1 ↗

NPASS

NPC311485

TCMID

15271

TCMSP

MOL004328; MOL001040

TCM-ID

2421

🔍 Raw view — every non-empty column on this row (33 fields)

name

Naringenin

common names

480-41-1; (S)-Naringenin; salipurpol; Naringenine; Salipurol; (S)-5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one; (2S)-Naringenin; pelargidanon; naringetol

herb ingredient id

HBIN036366

canonical smiles

C1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC=C(C=C3)O

isomeric smiles

C1[C@H](OC2=CC(=CC(=C2C1=O)O)O)C3=CC=C(C=C3)O

inchi

InChI=1S/C15H12O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-6,13,16-18H,7H2/t13-/m0/s1

inchikey

FTVWIRXFELQLPI-ZDUSSCGKSA-N

mol wt

272.2560

num h acceptors

num h donors

mol logp

2.5099

num rotatable bonds

drug likeness

0.742

cas id

67604-48-2; 480-41-1

tcmid ingredient id

15271

tcmsp ingredient id

MOL004328; MOL001040

tcm id ingredient id

2421

pubchem cid

439246

npass id

NPC311485

tcmsp mol id

MOL004328

tcmsp molecule id

4328

🌿 Related Herbs

1 · contains this compound

Ephedra

Ma Huang

🧬 Gene / Protein Targets

30 · directly binds these targets

CAT

Gene CAT

AKR1C1

Gene AKR1C1

FASN

Gene FASN

MAPK1

Gene MAPK1

MAPK3

Gene MAPK3

SOAT1

Gene SOAT1

SOAT2

Gene SOAT2

Prostaglandin G/H synthase 1

Estrogen receptor

Prostaglandin G/H synthase 2

Heat shock protein HSP 90

Beta-lactamase

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform

mRNA of PKA Catalytic Subunit C-alpha

Transcription factor p65

RAC-alpha serine/threonine-protein kinase

Apoptosis regulator Bcl-2

Caspase-3

Peroxisome proliferator-activated receptor gamma

Glutathione S-transferase P

Superoxide dismutase [Cu-Zn]

Peroxisome proliferator-activated receptor alpha

Low-density lipoprotein receptor

Bcl2 antagonist of cell death

Microsomal triglyceride transfer protein large subunit

Apolipoprotein B-100

Phospholipase B1, membrane-associated

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Cytochrome P450 19A1

UDP-glucuronosyltransferase 1-1

🏥 Linked Health Topics

30 · diseases via target pathways

Heart Failure

syndrome

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Endometrial Carcinoma

disease

Leukemia, Unspecified

disease

Metastatic osteosarcoma in the lung

Proliferative diseases

disease

Neurodegenerative diseases

disease

Traumatic brain injury

disease

Cardiovascular disease, unspecified

disease

Chronic inflammatory diseases

disease

Myocardial Infarction

syndrome

Osteoporosis

syndrome

Osteoporosis, unspecified

Coronary atherosclerosis

disease

Endocrine independent cancer

disease

Postmenopausal symptoms

disease

Migraine

disease

Cardiovascular disease

Carpal Tunnel Syndrome

syndrome

Endometriosis

syndrome

📚 PubMed References

4 · cited research

PMID 31758699 Naringenin attenuates non-alcoholic fatty liver disease by down-regulating the N

Br J Pharmacol

PMID 30527894 Naringenin targets on astroglial Nrf2 to support dopaminergic neurons

Pharmacol Res

PMID 21748601 Naringenin reduces lung metastasis in a breast cancer resection model

Protein Cell

PMID 21354229 Naringenin inhibits the assembly and long-term production of infectious hepatiti

J Hepatol

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables