Relationship Graph Explorer

Follow the connections

Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

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Herb

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🧪

Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Abetalipoproteinemia Abortion, Habitual Agenesis Acanthamoeba Keratitis Acanthosis Nigricans Achondrogenesis Achondroplasia Acne Vulgaris Acne Keloid Apert Syndrome

🏥 Disease / Health Topic

Bipolar Disorder

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

📋 Sample Trials

NCT03944447

Outcomes Mandate National Integration With Cannabis as Medicine

Recruiting · Phase 2

NCT01528839

Supraphysiological Doses of Levothyroxine as Adjunctive Therapy in Bipolar Depression

Completed · Phase 2|Phase 3

NCT00158990

Triiodothyronine (T3) Supplementation in the Treatment of Bipolar and Unipolar Depression.

Completed · Phase 3

📊 Sample Meta-Analyses

CRD42021268446

The neuropsychotropic effects of Crocus sativus L. (saffron): an overview of systematic review investigating its efficacy in the treatment of neurological and psychiatric disorders

Depressive disorders, Alzheimer, Parkinson, sexual dysfunction, anxiety disorder

CRD42022308316

Crocus sativus for insomnia in adults: a systematic review and meta-analysis

Depressive disorders, Alzheimer, Parkinson, sexual dysfunction, anxiety disorder

CRD42020218456

Efficacy and safety of supraphysiologic doses of levothyroxine for patients with bipolar disorder in the current depressive phase: a meta-analysis

Bipolar disorder

📚 Sample References

None linked yet.

🏥 All Disease / Health Topic data fields for Bipolar Disorder

🏥 Names

Disease Name

Bipolar Disorder

Alias Names

Bipolar Affective Disorder; Depression, Bipolar; Bipolar Affective Disorder, Unspecified; Manic Disorder; Mania; Bipolar Disorder

Topic Type

disease

🧬 Ontology Classifications

DisGeNET Type

disease

UMLS Type

Mental or Behavioral Dysfunction

MeSH Class

Mental Disorders

HPO Class

Abnormality of the nervous system

DO Class

disease of mental health

🔗 External References

HERB DB

MeSH

ICD-10

OMIM

HPO

Disease Ontology

3312

DisGeNET

C0005586

🔍 Raw view — every non-empty column on this row (31 fields)

name

Bipolar Disorder

alias name

Bipolar Affective Disorder; Depression, Bipolar; Bipolar Affective Disorder, Unspecified; Manic Disorder; Mania; Bipolar Disorder

topic type

disease

disgenet disease type

disease

umls disease type

Mental or Behavioral Dysfunction

mesh disease class

Mental Disorders

hpo disease class

Abnormality of the nervous system

do disease class

disease of mental health

umls disease type id

T048

mesh disease class id

F03

hpo disease class id

HP:0000707

do disease class id

DOID:150

herb disease id

HBDIS000329

disgenet id

C0005586

mesh id

D001714

hpo id

HP:0007302

do id

3312

icd10 id

F31.9; F31

omim id

611535

🌿 Related Herbs

1 · shared evidence

Da Ma

⚗️ Related Ingredients

12 · shared evidence

3,5,3',5'-tetraiodothyronine

3,5,3'-triiodothyronine

📋 Clinical Trials

12 · subject of clinical study

NCT03944447 Outcomes Mandate National Integration With Cannabis as Medicine

→ Chronic Pain|Chronic Pain Syndrome|Chronic Pain Du

NCT01528839 Supraphysiological Doses of Levothyroxine as Adjunctive Therapy in Bipolar Depre

→ Bipolar Disorder

NCT00158990 Triiodothyronine (T3) Supplementation in the Treatment of Bipolar and Unipolar D

→ Major Depression|Bipolar Disorder|Unipolar Depress

NCT00790738 Liothyronine (T3) for Bipolar Depression

→ Depression|Bipolar Disorder

NCT00195845 A Double-Blind, Placebo-Controlled Study of Galantamine to Improve Cognitive Dys

→ Bipolar Disorder

NCT00741598 Efficacy and Safety of Galantamine for Improving Dysfunction in People With Bipo

→ Bipolar Disorder

NCT01979133 Study of Icariin for Bipolar Disorder and Co-Occurring Substance Use Disorders

→ Bipolar Disorder|Substance Use Disorder

NCT00512070 Melatonin Metabolism Abnormality in Patients With Schizophrenia or Schizoaffecti

→ Schizophrenia|Schizoaffective Disorder|Bipolar Dis

NCT01409096 Study Using Pregnenolone to Treat Bipolar Depression

→ Bipolar Disorder|Major Depressive Disorder

NCT00217165 Taurine as an Anti-Manic Agent: A Double-Blind, Placebo-Controlled Study

→ Bipolar Disorder|Mania|Bipolar Depression

NCT00192725 Tryptophan Depletion in Acute Mania

→ Bipolar Disorder

NCT00841269 Oral Uridine for Treatment of Bipolar Depression in Adolescents

→ Bipolar Disorder

📊 Meta-Analyses

12 · systematic review

CRD42021268446 The neuropsychotropic effects of Crocus sativus L. (saffron): an overview of sys

→ Depressive disorders, Alzheimer, Parkinson, sexual

CRD42022308316 Crocus sativus for insomnia in adults: a systematic review and meta-analysis

→ Depressive disorders, Alzheimer, Parkinson, sexual

CRD42020218456 Efficacy and safety of supraphysiologic doses of levothyroxine for patients with

→ Bipolar disorder

CRD42019119254 Cellular calcium levels and calcium signalling in bipolar disorder

→ Bipolar disorder, formerly known as manic depressi

CRD42018113025 The effects of caffeine intake in patients with bipolar disorder

→ Bipolar disorder.

CRD42019119766 Cannabidiol as a treatment for mood disorders: a systematic review

→ Mood disorders (Depressive disorders or Bipolar di

CRD42020199111 Risk of cancer in bipolar disorder and the protective role of lithium: a systema

→ To determine whether bipolar disorder bears an inc

CRD42020177329 A systematic review comparing definitions of lithium treatment efficacy in peopl

→ The outcome measures used when evaluating efficacy

CRD42020143432 Lithium and suicide prevention in mood disorders and in the general population:

→ Bipolar disorder, Major Depressive Disorder, Schiz

CRD42017055675 Efficacy and tolerability of lithium in treating acute mania in youth with bipol

→ Acute manic symptoms in children and adolescents d

CRD42016036959 Clinical correlates of lithium efficacy in young patients with bipolar disorder:

→ Child and adolescent bipolar disorder.

CRD42021265809 Effect of lithium on suicide and self-harm in affective spectrum disorders: a sy

→ Bipolar disorder, affective spectrum disorders

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables