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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Nca

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Nca

Glaucoma 3 Hyperphosphatemia 2 Polycystic Kidney Disease 2 Parkinson Disease 2 Covid19|Lymphopenia 1 Sickle Cell Disease 1 Acute Kidney Injury 1 Non Alcoholic Fatty Liver Disease 1 COVID-19 Infection 1 Safety Issues|Pharmacokinetic 1 Acne Vulgaris 1 Melasma 1

📋 Sample Trials

NCT00033436

Radiation Therapy With or Without Carbogen and Niacinamide in Treating Patients With Bladder Cancer

Completed · Phase 3

NCT00316472

The Effect of Oral Niacinamide on Serum Phosphorus Levels in Hemodialysis Patients

Completed · Phase 1

NCT00508885

The Effect of Oral Niacinamide on Plasma Phosphorus Levels in Peritoneal Dialysis Patients

Completed · Phase 1|Phase 2

📊 Sample Meta-Analyses

CRD42015020787

Topical azelaic acid, salicylic acid, nicotinamide, and sulphur for acne [Cochrane Protocol]

The Cochrane Skin Group

CRD42018093989

Efficacy and safety of nicotinamide in hemodialysis patients: protocol for a systematic review of randomized controlled trials

Hyperphosphatemia is a most common problem in dialysis patients. Phosphorus imba

CRD42021223823

Effect of nicotinamide in comparison with placebo, standard of care, no treatment or other treatment with neutral or weak effect in skin cancers chemoprophylaxis: a systematic review and meta-analysis

Skin cancers.

📚 Sample References

PMID 32014016

AICAR and nicotinamide treatment synergistically augment the proliferation and attenuate senescence-associated changes in mesenchymal stromal cells

Stem Cell Res Ther · 2020

PMID 32298659

Nicotinamide and its metabolite N1-Methylnicotinamide alleviate endocrine and metabolic abnormalities in adipose and ovarian tissues in rat model of Polycystic Ovary Syndrome

Chem Biol Interact · 2020

PMID 32630550

Nicotinamide Supplementation during the In Vitro Maturation of Oocytes Improves the Developmental Competence of Preimplantation Embryos: Potential Link to SIRT1/AKT Signaling

Cells · 2020

⚗️ All Ingredient data fields for Nca

⚗️ Identity

Name

Nca

Aliases / Synonyms

nicotinamide; niacinamide; 98-92-0; 3-Pyridinecarboxamide; pyridine-3-carboxamide; Nicotinic acid amide; vitamin PP; Aminicotin; Amixicotyn; Papulex

🧪 Chemistry

Molecular Weight

122.1270

LogP

0.1805

Drug-likeness

0.577

Oral Bioavailability

71.1260

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C1=CC(=CN=C1)C(=O)N

Isomeric SMILES

C1=CC(=CN=C1)C(=O)N

InChIKey

DFPAKSUCGFBDDF-UHFFFAOYSA-N

InChI

InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

🔗 External References

HERB DB

HBIN036452 ↗

PubChem CID

936 ↗

CAS Number

98-92-0 ↗

NPASS

NPC306397

HIT

C0246

SymMap

3369

TCMID

33756; 40087

TCMSP

MOL000857

🔍 Raw view — every non-empty column on this row (33 fields)

name

Nca

common names

nicotinamide; niacinamide; 98-92-0; 3-Pyridinecarboxamide; pyridine-3-carboxamide; Nicotinic acid amide; vitamin PP; Aminicotin; Amixicotyn; Papulex

herb ingredient id

HBIN036452

canonical smiles

C1=CC(=CN=C1)C(=O)N

isomeric smiles

C1=CC(=CN=C1)C(=O)N

inchi

InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

inchikey

DFPAKSUCGFBDDF-UHFFFAOYSA-N

mol wt

122.1270

num h acceptors

num h donors

mol logp

0.1805

num rotatable bonds

drug likeness

0.577

ob score

71.1260

cas id

98-92-0

symmap mol id

3369

tcmid ingredient id

33756; 40087

tcmsp ingredient id

MOL000857

pubchem cid

936

npass id

NPC306397

hit id

C0246

🏥 Linked Health Topics

9 · studied for these conditions (text bridge)

Chronic Lymphocytic Leukemia

Progressive Supranuclear Palsy

📋 Clinical Trials

12 · subject of clinical study

NCT00033436 Radiation Therapy With or Without Carbogen and Niacinamide in Treating Patients

→ Bladder Cancer

NCT00316472 The Effect of Oral Niacinamide on Serum Phosphorus Levels in Hemodialysis Patien

→ Hyperphosphatemia

NCT00508885 The Effect of Oral Niacinamide on Plasma Phosphorus Levels in Peritoneal Dialysi

→ Hyperphosphatemia

NCT00580931 Safety Study of Nicotinamide to Treat Alzheimer's Disease

→ Alzheimer's Disease

NCT00605930 A Pilot Clinical Trial of Pyruvate, Creatine, and Niacinamide in Progressive Sup

→ Progressive Supranuclear Palsy

NCT00691210 Phase I Vorinostat in Combination With Niacinamide and Etoposide for Lymphoid Ma

→ Hodgkin's Disease|Non-Hodgkin's Lymphoma

NCT01200784 Nicotinamide in Hemodialysis Patients With Hyperphosphatemia

→ Chronic Kidney Disease|Hemodialysis|Hyperphosphate

NCT01542138 Clinical Trial of 4% Niacinamide Versus 0.05% Desonide for the Treatment of Axil

→ Hyperpigmentation

NCT01763424 Nicotinamide in the Treatment of Psoriasis

→ Psoriasis

NCT02140814 Uncontrolled, Open Label, Pilot and Feasibility Study of Niacinamide in Polycyst

→ Polycystic Kidney Disease

NCT02213094 Phase I Study of Nicotinamide for Early Onset Preeclampsia

→ Pregnancy Induced Hypertension|Superimposed Preecl

NCT02558595 Pilot Study of Niacinamide in Polycystic Kidney Disease (NIAC-PKD2)

→ Polycystic Kidney Disease

📊 Meta-Analyses

3 · systematic review

CRD42015020787 Topical azelaic acid, salicylic acid, nicotinamide, and sulphur for acne [Cochra

→ The Cochrane Skin Group

CRD42018093989 Efficacy and safety of nicotinamide in hemodialysis patients: protocol for a sys

→ Hyperphosphatemia is a most common problem in dial

CRD42021223823 Effect of nicotinamide in comparison with placebo, standard of care, no treatmen

→ Skin cancers.

📚 PubMed References

12 · cited research

PMID 32014016 AICAR and nicotinamide treatment synergistically augment the proliferation and a

Stem Cell Res Ther

PMID 32298659 Nicotinamide and its metabolite N1-Methylnicotinamide alleviate endocrine and me

Chem Biol Interact

PMID 32630550 Nicotinamide Supplementation during the In Vitro Maturation of Oocytes Improves

Cells

PMID 33028392 Nicotinamide inhibits melanoma in vitro and in vivo

J Exp Clin Cancer Res

PMID 33143523 Nicotinamide Improves Delayed Tooth Eruption in Runx2+/- Mice

J Dent Res

PMID 33233455 Nicotinamide Prevents Apolipoprotein B-Containing Lipoprotein Oxidation, Inflamm

Antioxidants (Basel)

PMID 33305362 Nicotinamide ameliorates energy deficiency and improves retinal function in Cav-

J Neurochem

PMID 33802063 Nicotinamide Treatment Facilitates Mitochondrial Fission through Drp1 Activation

Cells

PMID 34172095 Nicotinamide promotes pancreatic differentiation through the dual inhibition of

Stem Cell Res Ther

PMID 34544355 The mechanism of nicotinamide on reducing acute lung injury by inhibiting MAPK a

Mol Med

PMID 34695410 Nicotinamide Attenuates UV-Induced Stress Damage in Human Primary Keratinocytes

J Invest Dermatol

PMID 34740582 Nicotinamide Prevents UVB- and Oxidative Stress‒Induced Photoaging in Human Prim

J Invest Dermatol

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables