Relationship Graph Explorer

Follow the connections

Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

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🧪

Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Nicotine

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Nicotine

Depressive Disorder 2 Nicotine Vaping|Nicotine Dependence 1

📋 Sample Trials

NCT06027723

Nicotine and Pavlovian Bias

Recruiting · Early_Phase 1

NCT05746546

Depressed Mood Improvement Through Nicotine Dosing-3 (Depressed MIND3) Extension

Recruiting · Phase 2

NCT05746273

Depressed Mood Improvement Through Nicotine Dosing 3

Recruiting · Phase 2

📊 Sample Meta-Analyses

None linked yet.

📚 Sample References

None linked yet.

⚗️ All Ingredient data fields for Nicotine

⚗️ Identity

Name

Nicotine

Aliases / Synonyms

L-Nicotine; 54-11-5; (-)-Nicotine; (S)-Nicotine; (S)-3-(1-methylpyrrolidin-2-yl)pyridine; (S)-(-)-Nicotine; Habitrol; Nicotrol; 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine

🧪 Chemistry

Molecular Weight

162.2360

LogP

1.8483

Drug-likeness

0.626

Oral Bioavailability

77.6680

H-Bond Acceptors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CN1CCCC1C2=CN=CC=C2

Isomeric SMILES

CN1CCC[C@H]1C2=CN=CC=C2

InChIKey

SNICXCGAKADSCV-JTQLQIEISA-N

InChI

InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1

🔗 External References

HERB DB

HBIN036905 ↗

PubChem CID

89594 ↗

CAS Number

20033 ↗

NPASS

NPC182571

SymMap

177

TCMID

23307

TCMSP

MOL003403

TCM-ID

2317

🔍 Raw view — every non-empty column on this row (33 fields)

name

Nicotine

common names

L-Nicotine; 54-11-5; (-)-Nicotine; (S)-Nicotine; (S)-3-(1-methylpyrrolidin-2-yl)pyridine; (S)-(-)-Nicotine; Habitrol; Nicotrol; 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine

herb ingredient id

HBIN036905

canonical smiles

CN1CCCC1C2=CN=CC=C2

isomeric smiles

CN1CCC[C@H]1C2=CN=CC=C2

inchi

InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1

inchikey

SNICXCGAKADSCV-JTQLQIEISA-N

mol wt

162.2360

num h acceptors

num h donors

mol logp

1.8483

num rotatable bonds

drug likeness

0.626

ob score

77.6680

cas id

20033

symmap mol id

177

tcmid ingredient id

23307

tcmsp ingredient id

MOL003403

tcm id ingredient id

2317

pubchem cid

89594

npass id

NPC182571

🏥 Linked Health Topics

1 · diseases via target pathways

Depressive Disorder

disease

📋 Clinical Trials

3 · subject of clinical study

NCT06027723 Nicotine and Pavlovian Bias

→ Nicotine Vaping|Nicotine Dependence

NCT05746546 Depressed Mood Improvement Through Nicotine Dosing-3 (Depressed MIND3) Extension

→ Depressive Disorder

NCT05746273 Depressed Mood Improvement Through Nicotine Dosing 3

→ Depressive Disorder

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables