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Ingredient
44,598
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Gene Target
15,695
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Disease
30,467
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Evidence
23,295
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
⚗️ Ingredient
Nifedipine
1
Clinical Trials
19
Meta-Analyses
0
PubMed References
Top Conditions Studied with Nifedipine
Gestational age under 37 weeks with labor contraction, Gravi 2
Preterm is a common cause of neonatal morbidityand mortality 1
All types of hypertensive disorders of pregnancy can be comp 1
Preterm birth (PTB) is defined as birth prior to 37 weeks of 1
Preterm Labor Without Delivery|Pregnancy Preterm 1
premature labor 1
Pregnant women with an indication for methyldopa, nifedipine 1
International guidelines define severe hypertension in pregn 1
we conducted a systematic review and network meta-analysis t 1
Hypertension is the most common disorder in pregnancy. The h 1
Urolithiasis is a disease that affects 12% of the world popu 1
Gingival enlargement caused due to drugs such as amlodipine, 1
📋 Sample Trials
NCT05520021
The Treatment of Magnesium Sulfate and Nifedipine in Preterm Labor Threat
Unknown
📊 Sample Meta-Analyses
CRD42017055143
Isosorbide and nifedipine for treatment of achalasia in patients with digestive clinical form of chronic Chagas disease: a systematic review
Chagas disease, also known as American trypanosomiasis, is a zoonosis that affec
CRD42021290768
The comparison of efficacy of nifedipine and magnesium sulfate on preterm labor: systematic review and meta-analysis
Gestational age under 37 weeks with labor contraction, Gravida, Para, BMI, Gesta
CRD42022296674
Progesterone and nifedipine for maintenance tocolysis after arrested preterm labor: An updated systematic review and meta-analysis of randomized controlled trial
Preterm is a common cause of neonatal morbidityand mortality.in ours systematic
📚 Sample References
None linked yet.
⚗️ All Ingredient data fields for Nifedipine
⚗️ Identity
Name
Nifedipine
Aliases / Synonyms
21829-25-4; Adalat; Procardia; Procardia XL; Adalat CC; Fenihidine; Citilat; Cordipin; Corinfar
🧪 Chemistry
Molecular Weight
346.3390
LogP
2.1756
Drug-likeness
0.506
H-Bond Acceptors
7
H-Bond Donors
1
Rotatable Bonds
4
🔬 Structures
Canonical SMILES
CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
Isomeric SMILES
CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
InChIKey
HYIMSNHJOBLJNT-UHFFFAOYSA-N
InChI
InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3
🔗 External References
🔍 Raw view — every non-empty column on this row (29 fields)
name
Nifedipine
common names
21829-25-4; Adalat; Procardia; Procardia XL; Adalat CC; Fenihidine; Citilat; Cordipin; Corinfar
herb ingredient id
HBIN036913
canonical smiles
CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
isomeric smiles
CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
inchi
InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3
inchikey
HYIMSNHJOBLJNT-UHFFFAOYSA-N
mol wt
346.3390
num h acceptors
7
num h donors
1
mol logp
2.1756
num rotatable bonds
4
drug likeness
0.506
tcm id ingredient id
13340
pubchem cid
4485
npass id
NPC190945
hit id
C0248
📋 Clinical Trials
1 · subject of clinical studyNCT05520021 The Treatment of Magnesium Sulfate and Nifedipine in Preterm Labor Threat
→ Preterm Labor Without Delivery|Pregnancy Preterm
📊 Meta-Analyses
12 · systematic reviewCRD42017055143 Isosorbide and nifedipine for treatment of achalasia in patients with digestive
→ Chagas disease, also known as American trypanosomi
CRD42021290768 The comparison of efficacy of nifedipine and magnesium sulfate on preterm labor:
→ Gestational age under 37 weeks with labor contract
CRD42022296674 Progesterone and nifedipine for maintenance tocolysis after arrested preterm lab
→ Preterm is a common cause of neonatal morbidityand
CRD42020152714 Comparative Efficacy and Safety of Oral Nifedipine & I.V Labetalol for Hyper
→ All types of hypertensive disorders of pregnancy c
CRD42021269575 Different dosage regimens of nifedipine, labetalol, and hydralazine for the trea
→ International guidelines define severe hypertensio
CRD42021290766 The comparison of efficacy of nifedipine and ritodrine on preterm labor: systema
→ Gestational age under 37 weeks with labor contract
CRD42019128415 The pharmacokinetics of the antihypertensive drugs methyldopa, nifedipine and la
→ Pregnant women with an indication for methyldopa,
CRD42020202428 Morphological, and Histological effects of Calcium Channel Blockers (Nifedipine
→ Gingival enlargement caused due to drugs such as a
CRD42021230008 Comparison of the effectiveness of nifedipine and transdermal nitroglycerin in t
→ Gestational age under 37 weeks with labor contract
CRD42014008763 Nifedipine vs. labetalol for treatment of hypertensive crisis during pregnancy:
→ All types of hypertensive disorders of pregnancy c
CRD42016024244 Nifedipine versus atosiban in treatment of threatened preterm labor: an individu
→ Tocolytics are administered in threatened preterm
CRD42015027734 Are tamsulosin and nifedipine not effective for ureteral stones? A systematic re
→ Urolithiasis is a disease that affects 12% of the
How relationships are computed
- Clinical Trials / Meta-Analyses / References: direct foreign-key link via
subject_entity_id(Phase 2d wireup) - Formula ↔ Herbs: text bridge via
formulas.herbs_in_pinyinmatchingherbs.pinyin_name - Herb ↔ Ingredient:
ACTIVE — direct link via
herb_ingredients - Ingredient ↔ Target:
ACTIVE — direct link via
ingredient_targets - Target ↔ Disease:
ACTIVE — direct link via
target_health_topics - Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables