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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Oleuropein

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Oleuropein

Muscular Fatigue 1 Healthy Subjects 1 Studies that assess specific health conditions will be evalu 1 Knowing that cardiovascular diseases are the major cause of 1 Periodontitis 1

📋 Sample Trials

NCT04328571

Effects of Enzymatic Digestion and Probiotic on Oleuropein Bioavailability

Completed

NCT05217433

Oleuropein and Muscle Energy Metabolism

Completed

NCT05482373

Adjuvant Treatment in Elderly Patients With Periodontitis Through the Administration of a Supplement Rich in Oleuropein From the Olive Leaf

Recruiting

📊 Sample Meta-Analyses

CRD42019129083

Association between olive leaf oleuropein and cardiovascular diseases: a systematic review

CRD42021273708

The antioxidant effect of oleuropein consumption on cardiovascular disease in the adult population: a systematic review.

Knowing that cardiovascular diseases are the major cause of death nowadays, it i

CRD42022375615

Olive leaf oleuropein effects in metabolism: a systematic review of randomized controlled trials

Studies that assess specific health conditions will be evaluated. This means stu

📚 Sample References

PMID 28057028

Oleuropein enhances radiation sensitivity of nasopharyngeal carcinoma by downregulating PDRG1 through HIF1α-repressed microRNA-519d

J Exp Clin Cancer Res · 2017

PMID 24486195

Oleuropein prevents doxorubicin-induced cardiomyopathy interfering with signaling molecules and cardiomyocyte metabolism

J Mol Cell Cardiol · 2014

PMID 22214867

Preventive and therapeutic effects of oleuropein against carbon tetrachloride-induced liver damage in mice

Pharmacol Res · 2012

⚗️ All Ingredient data fields for Oleuropein

⚗️ Identity

Name

Oleuropein

Aliases / Synonyms

32619-42-4; Oleoeuropein; oleoeuropeine; EINECS 251-129-6; UNII-2O4553545L; OLEUROPEIN [MI]; OLEUROPEIN [VANDF]; OLEUROPEIN [USP-RS]; OLEUROPEIN [WHO-DD]

🧪 Chemistry

Molecular Weight

540.5180

LogP

-0.6342

Drug-likeness

0.131

Oral Bioavailability

4.9530

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC=C1C(C(=COC1OC2C(C(C(C(O2)CO)O)O)O)C(=O)OC)CC(=O)OCCC3=CC(=C(C=C3)O)O

Isomeric SMILES

C/C=C/1\[C@@H](C(=CO[C@H]1O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)C(=O)OC)CC(=O)OCCC3=CC(=C(C=C3)O)O

InChIKey

RFWGABANNQMHMZ-ZCHJGGQASA-N

InChI

InChI=1S/C25H32O13/c1-3-13-14(9-19(29)35-7-6-12-4-5-16(27)17(28)8-12)15(23(33)34-2)11-36-24(13)38-25-22(32)21(31)20(30)18(10-26)37-25/h3-5,8,11,14,18,20-22,24-28,30-32H,6-7,9-10H2,1-2H3/b13-3+/t14-,18+,20+,21-,22+,24-,25-/m0/s1

🔗 External References

HERB DB

HBIN038054 ↗

PubChem CID

5281544 ↗

CAS Number

32619-42-4 ↗

SymMap

226

TCMID

16070

TCMSP

MOL005176

TCM-ID

2092

🔍 Raw view — every non-empty column on this row (32 fields)

name

Oleuropein

common names

32619-42-4; Oleoeuropein; oleoeuropeine; EINECS 251-129-6; UNII-2O4553545L; OLEUROPEIN [MI]; OLEUROPEIN [VANDF]; OLEUROPEIN [USP-RS]; OLEUROPEIN [WHO-DD]

herb ingredient id

HBIN038054

canonical smiles

CC=C1C(C(=COC1OC2C(C(C(C(O2)CO)O)O)O)C(=O)OC)CC(=O)OCCC3=CC(=C(C=C3)O)O

isomeric smiles

C/C=C/1\[C@@H](C(=CO[C@H]1O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)C(=O)OC)CC(=O)OCCC3=CC(=C(C=C3)O)O

inchi

inchikey

RFWGABANNQMHMZ-ZCHJGGQASA-N

mol wt

540.5180

num h acceptors

num h donors

mol logp

-0.6342

num rotatable bonds

drug likeness

0.131

ob score

4.9530

cas id

32619-42-4

symmap mol id

226

tcmid ingredient id

16070

tcmsp ingredient id

MOL005176

tcm id ingredient id

2092

pubchem cid

5281544

🏥 Linked Health Topics

1 · studied for these conditions (text bridge)

Periodontitis

syndrome

📋 Clinical Trials

3 · subject of clinical study

NCT04328571 Effects of Enzymatic Digestion and Probiotic on Oleuropein Bioavailability

→ Healthy Subjects

NCT05217433 Oleuropein and Muscle Energy Metabolism

→ Muscular Fatigue

NCT05482373 Adjuvant Treatment in Elderly Patients With Periodontitis Through the Administra

→ Periodontitis

📊 Meta-Analyses

3 · systematic review

CRD42019129083 Association between olive leaf oleuropein and cardiovascular diseases: a systema

CRD42021273708 The antioxidant effect of oleuropein consumption on cardiovascular disease in th

→ Knowing that cardiovascular diseases are the major

CRD42022375615 Olive leaf oleuropein effects in metabolism: a systematic review of randomized c

→ Studies that assess specific health conditions wil

📚 PubMed References

10 · cited research

PMID 28057028 Oleuropein enhances radiation sensitivity of nasopharyngeal carcinoma by downreg

J Exp Clin Cancer Res

PMID 24486195 Oleuropein prevents doxorubicin-induced cardiomyopathy interfering with signalin

J Mol Cell Cardiol

PMID 22214867 Preventive and therapeutic effects of oleuropein against carbon tetrachloride-in

Pharmacol Res

PMID 21145829 Oleuropein attenuates hepatic steatosis induced by high-fat diet in mice

J Hepatol

PMID 32598912 Oleuropein promotes hippocampal LTP via intracellular calcium mobilization and C

Neuropharmacology

PMID 33582227 Acute administration of the olive constituent, oleuropein, combined with ischemi

Free Radic Biol Med

PMID 33841147 Oleuropein Attenuates Lipopolysaccharide-Induced Acute Kidney Injury In Vitro an

Front Pharmacol

PMID 33894272 Oleuropein reduces cisplatin resistance in ovarian cancer by targeting apoptotic

Life Sci

PMID 35964244 Oleuropein attenuates inflammation and regulates immune responses in a 2,4-dinit

Asian Pac J Allergy Immunol

PMID 36419064 Oleuropein suppresses endometriosis progression and improves the fertility of mi

J Biomed Sci

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables