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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Oxymatrine

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Oxymatrine

Chronic hepatitis B is a long term infectious inflammatory i 1 Chronic Hepatitis B 1 The latest clinical practice guidelines published by Europea 1 Oxymatrine and human liver cancer Bel-7404 cells 1

📋 Sample Trials

NCT02202473

Oxymatrine Plus Lamivudine Combination Therapy Versus Lamivudine Monotherapy for Chronic Hepatitis B Infected Subjects

Completed · Phase 4

📊 Sample Meta-Analyses

CRD42013005997

Oral oxymatrine preparation for chronic hepatitis B: a systematic review of randomized clinical trials

Chronic hepatitis B is a long term infectious inflammatory illness of the liver

CRD42018095275

Oral oxymatrine for hepatitis B cirrhosis: a systematic review of randomized clinical trials

The latest clinical practice guidelines published by European Association for th

CRD42020166497

Effects of oxymatrine on the proliferation of human liver cancer Bel-7404 cells: a protocol of systematic review and meta-analysis

Oxymatrine and human liver cancer Bel-7404 cells

📚 Sample References

PMID 30822359

Oxymatrine therapy inhibited epidermal cell proliferation and apoptosis in severe plaque psoriasis

Br J Dermatol · 2019

PMID 21714853

Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and releasing of cytochrome c

J Exp Clin Cancer Res · 2011

PMID 32581789

Oxymatrine Inhibits Renal Cell Carcinoma Progression by Suppressing β-Catenin Expression

Front Pharmacol · 2020

⚗️ All Ingredient data fields for Oxymatrine

⚗️ Identity

Name

Oxymatrine

Aliases / Synonyms

16837-52-8; Ammothamnine; Matrine N-oxide; Matrine oxide; Matrine 1beta-oxide; CHEBI:2672; 54809-74-4; MFCD00210339; (7aS,13aR,13bR,13cS)dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one 4-oxide

🧪 Chemistry

Molecular Weight

264.3690

LogP

1.8843

Drug-likeness

0.495

Oral Bioavailability

0.3480

H-Bond Acceptors

🔬 Structures

Canonical SMILES

C1CC2C3CCC[N+]4(C3C(CCC4)CN2C(=O)C1)[O-]

Isomeric SMILES

C1C[C@@H]2[C@H]3CCC[N+]4([C@H]3[C@@H](CCC4)CN2C(=O)C1)[O-]

InChIKey

XVPBINOPNYFXID-LHDUFFHYSA-N

InChI

InChI=1S/C15H24N2O2/c18-14-7-1-6-13-12-5-3-9-17(19)8-2-4-11(15(12)17)10-16(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-,17?/m0/s1

🔗 External References

HERB DB

HBIN038488 ↗

PubChem CID

114850 ↗

CAS Number

16837-52-8 ↗

SymMap

249

TCMID

16440

TCMSP

MOL006634

TCM-ID

1849

🔍 Raw view — every non-empty column on this row (32 fields)

name

Oxymatrine

common names

herb ingredient id

HBIN038488

canonical smiles

C1CC2C3CCC[N+]4(C3C(CCC4)CN2C(=O)C1)[O-]

isomeric smiles

C1C[C@@H]2[C@H]3CCC[N+]4([C@H]3[C@@H](CCC4)CN2C(=O)C1)[O-]

inchi

InChI=1S/C15H24N2O2/c18-14-7-1-6-13-12-5-3-9-17(19)8-2-4-11(15(12)17)10-16(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-,17?/m0/s1

inchikey

XVPBINOPNYFXID-LHDUFFHYSA-N

mol wt

264.3690

num h acceptors

num h donors

mol logp

1.8843

num rotatable bonds

drug likeness

0.495

ob score

0.3480

cas id

16837-52-8

symmap mol id

249

tcmid ingredient id

16440

tcmsp ingredient id

MOL006634

tcm id ingredient id

1849

pubchem cid

114850

📋 Clinical Trials

1 · subject of clinical study

NCT02202473 Oxymatrine Plus Lamivudine Combination Therapy Versus Lamivudine Monotherapy for

→ Chronic Hepatitis B

📊 Meta-Analyses

3 · systematic review

CRD42013005997 Oral oxymatrine preparation for chronic hepatitis B: a systematic review of rand

→ Chronic hepatitis B is a long term infectious infl

CRD42018095275 Oral oxymatrine for hepatitis B cirrhosis: a systematic review of randomized cli

→ The latest clinical practice guidelines published

CRD42020166497 Effects of oxymatrine on the proliferation of human liver cancer Bel-7404 cells:

→ Oxymatrine and human liver cancer Bel-7404 cells

📚 PubMed References

9 · cited research

PMID 30822359 Oxymatrine therapy inhibited epidermal cell proliferation and apoptosis in sever

Br J Dermatol

PMID 21714853 Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating

J Exp Clin Cancer Res

PMID 32581789 Oxymatrine Inhibits Renal Cell Carcinoma Progression by Suppressing β-Catenin Ex

Front Pharmacol

PMID 32679144 Oxymatrine alleviated hepatic lipid metabolism via regulating miR-182 in non-alc

Life Sci

PMID 33273999 Oxymatrine Ameliorates Memory Impairment in Diabetic Rats by Regulating Oxidativ

Oxid Med Cell Longev

PMID 33927621 Neuroprotective Effects of Oxymatrine on PI3K/Akt/mTOR Pathway After Hypoxic-Isc

Front Pharmacol

PMID 34136493 Oxymatrine Attenuates Osteoclastogenesis via Modulation of ROS-Mediated SREBP2 S

Front Cell Dev Biol

PMID 35609310 Oxymatrine induces anti-tumor response in cervical cancer by modulating circ_000

Bioengineered

PMID 36584572 Oxymatrine ameliorated experimental colitis via mechanisms involving inflammator

Int Immunopharmacol

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables