Relationship Graph Explorer

Follow the connections

Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

🌿

Herb

→

→

→

→

🧪

Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Oxytocin

Open on HERB 2.0 ↗

332

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Oxytocin

Postpartum Hemorrhage 35 Healthy 32 Schizophrenia 11 Prader-Willi Syndrome 6 Autism Spectrum Disorders 6 Induction of Labor 5 Autism Spectrum Disorder 5 Healthy Volunteer Study 3 Cocaine Dependence 3 Healthy Male Volunteers 3 Post Partum Hemorrhage 3 Labour and birth 3

📋 Sample Trials

NCT03578263

Carbetocin Versus Oxytocin and Ergometrine for the Prevention of Postpartum Hemorrhage

Completed

NCT01012167

Oxytocin or Galantamine Versus Placebo for the Treatment of Negative Symptoms and Cognitive Impairments in Schizophrenia

Completed · Phase 2

NCT00263796

An fMRI Study of the Effect of Intravenous Oxytocin vs. Placebo on Response Inhibition and Face Processing in Autism

Completed · Phase 1

📊 Sample Meta-Analyses

CRD42014013196

Misoprostol versus ergometrine-oxytocin for preventing postpartum hemorrhage: systematic review and meta-analysis of randomized controlled trials and the implications for developing countries

Postpartum hemorrhage (PPH) is a major cause of maternal mortality, accounting f

CRD42015016979

Intranasal oxytocin for autism spectrum disorders (ASD) [Cochrane Protocol]

The Cochrane Developmental, Psychosocial and Learning Problems Group

CRD42015024068

Oxytocin for preventing postpartum haemorrhage (PPH) in non-facility birth settings [Cochrane Protocol]

The Cochrane Pregnancy and Childbirth Group

📚 Sample References

PMID 30262887

Neurochemical evidence for differential effects of acute and repeated oxytocin administration

Mol Psychiatry · 2021

PMID 34483895

Oxytocin Attenuates Methamphetamine-Induced Apoptosis via Oxytocin Receptor in Rat Hippocampal Neurons

Front Pharmacol · 2021

PMID 34733156

Protective Effect of Oxytocin on Ventilator-Induced Lung Injury Through NLRP3-Mediated Pathways

Front Pharmacol · 2021

⚗️ All Ingredient data fields for Oxytocin

⚗️ Identity

Name

Oxytocin

Aliases / Synonyms

50-56-6; Pitocin; Endopituitrina; Ocytocin; Syntocinon; Oxytocinum; Orasthin; Oxystin; alpha-Hypophamine

🧪 Chemistry

Molecular Weight

1007.2070

LogP

-3.6086

Drug-likeness

0.067

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N

Isomeric SMILES

CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N

InChIKey

XNOPRXBHLZRZKH-DSZYJQQASA-N

InChI

InChI=1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1

🔗 External References

HERB DB

HBIN038531 ↗

PubChem CID

439302 ↗

NPASS

NPC326349

HIT

C0280

TCMID

16467

🔍 Raw view — every non-empty column on this row (29 fields)

name

Oxytocin

common names

50-56-6; Pitocin; Endopituitrina; Ocytocin; Syntocinon; Oxytocinum; Orasthin; Oxystin; alpha-Hypophamine

herb ingredient id

HBIN038531

canonical smiles

CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N

isomeric smiles

CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N

inchi

inchikey

XNOPRXBHLZRZKH-DSZYJQQASA-N

mol wt

1007.2070

num h acceptors

num h donors

mol logp

-3.6086

num rotatable bonds

drug likeness

0.067

tcmid ingredient id

16467

pubchem cid

439302

npass id

NPC326349

hit id

C0280

🏥 Linked Health Topics

12 · studied for these conditions (text bridge)

Antisocial Personality Disorder

Postpartum Hemorrhage

phenotype

📋 Clinical Trials

12 · subject of clinical study

NCT03578263 Carbetocin Versus Oxytocin and Ergometrine for the Prevention of Postpartum Hemo

→ Cesarean Section Complications

NCT01012167 Oxytocin or Galantamine Versus Placebo for the Treatment of Negative Symptoms an

→ Schizophrenia

NCT00263796 An fMRI Study of the Effect of Intravenous Oxytocin vs. Placebo on Response Inhi

→ Autism

NCT00468520 Adjuvant Oxytocin for Preinduction Ripening With a Foley catheter--a Clinical Tr

→ Pregnancy|Induced Labor|Cervical Ripening

NCT00481533 Ergot and Oxytocin During Cesarean Delivery Following Failure to Progress in Lab

→ Blood Loss, Surgical

NCT00490802 Intranasal Oxytocin in the Treatment of Autism

→ Autism

NCT00784797 Misopristol Versus Pitocin for Second Trimester Abortion

→ Abortion, Missed

NCT00785395 Up-Down Oxytocin Infusion

→ Uterine Atony

NCT00788255 In-vitro Study to Assess the Coagulation Effects of Exogenous Oxytocin Using Thr

→ Anesthesia

NCT00790062 Oxytocin Regimen to Prevent Atony and Postpartum Hemorrhage During Vaginal Deliv

→ Uterine Atony|Postpartum Hemorrhage

NCT00844350 The Effect of Oxytocin (OT) and Oxytocin Plus Human Chorionic Gonadotropin (hCG)

→ Ovarian Response

NCT00884897 Oxytocin and Social Cognition in Schizophrenia

→ Social Cognition|Social Anxiety|Emotional Intellig

📊 Meta-Analyses

12 · systematic review

CRD42014013196 Misoprostol versus ergometrine-oxytocin for preventing postpartum hemorrhage: sy

→ Postpartum hemorrhage (PPH) is a major cause of ma

CRD42015016979 Intranasal oxytocin for autism spectrum disorders (ASD) [Cochrane Protocol]

→ The Cochrane Developmental, Psychosocial and Learn

CRD42015024068 Oxytocin for preventing postpartum haemorrhage (PPH) in non-facility birth setti

→ The Cochrane Pregnancy and Childbirth Group

CRD42015026567 Continuous versus pulsatile oxytocin administration for the augmentation of labo

→ The Cochrane Pregnancy and Childbirth Group

CRD42015027864 The relationship between central and peripheral oxytocin concentrations

→ Oxytocin concentrations, Psychiatric conditions (e

CRD42015029461 Oxytocin bolus versus continuous infusion for the prophylactic reduction of bloo

→ Excessive blood loss and uterine atony are common

CRD42016038781 The impact of oxytocin administration on brain activity: a systematic review and

→ Brain activity, psychiatric conditions (e.g., auti

CRD42016053015 The effect of dietary intake and behaviours on oxytocin: a systematic review

→ The interrelationship between dietary intake and/o

CRD42017055107 Oxytocin antagonists for assisted reproduction [Cochrane Protocol]

→ The Cochrane Menstrual Disorders and Subfertility

CRD42017065683 Continuing or discontinuing oxytocin infusion in active phase of labor: a system

→ There is no consensus regarding whether discontinu

CRD42017068167 Systematic review on pharmacokinetic and pharmacodynamic properties of oxytocin

→ Pharmacokinetics and pharmacodynamics.

CRD42017079377 The effects of oxytocin intranasal administration for autism spectrum disorders:

→ Autism spectrum disorder (ASD) is a neurodevelopme

📚 PubMed References

5 · cited research

PMID 30262887 Neurochemical evidence for differential effects of acute and repeated oxytocin a

Mol Psychiatry

PMID 34483895 Oxytocin Attenuates Methamphetamine-Induced Apoptosis via Oxytocin Receptor in R

Front Pharmacol

PMID 34733156 Protective Effect of Oxytocin on Ventilator-Induced Lung Injury Through NLRP3-Me

Front Pharmacol

PMID 34863977 Oxytocin suppresses epithelial cell-derived cytokines production and alleviates

Biochem Pharmacol

PMID 34925023 Oxytocin Protects Against Isoproterenol-Induced Cardiac Hypertrophy by Inhibitin

Front Pharmacol

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables