Relationship Graph Explorer

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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Parthenolide

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Parthenolide

Allergic Contact Dermatitis 1

📋 Sample Trials

NCT00133341

Clinical Evaluation of the 3 Allergens: Methyldibromoglutharonitrile, Parthenolide and Goldnatriumthiosulphate

Completed · Phase 2

📊 Sample Meta-Analyses

None linked yet.

📚 Sample References

PMID 31078744

Parthenolide, a feverfew-derived phytochemical, ameliorates obesity and obesity-induced inflammatory responses via the Nrf2/Keap1 pathway

Pharmacol Res · 2019

PMID 28965856

Pharmacological evidence for the bone-autonomous contribution of the NFκB/β-catenin axis to breast cancer related osteolysis

Cancer Lett · 2017

PMID 26821066

The clerodane diterpene casearin J induces apoptosis of T-ALL cells through SERCA inhibition, oxidative stress, and interference with Notch1 signaling

Cell Death Dis · 2016

⚗️ All Ingredient data fields for Parthenolide

⚗️ Identity

Name

Parthenolide

Aliases / Synonyms

20554-84-1; (-)-Parthenolide; MFCD00134592; CHEBI:7939; PARTHENOLIDE [MI]; 2RDB26I5ZB; PARTHENOLIDE [USP-RS]; PARTHENOLIDE [WHO-DD]; CHEMBL465158

🧪 Chemistry

Molecular Weight

248.3220

LogP

2.7620

Drug-likeness

0.286

H-Bond Acceptors

🔬 Structures

Canonical SMILES

CC1=CCCC2(C(O2)C3C(CC1)C(=C)C(=O)O3)C

Isomeric SMILES

C/C/1=C\CC[C@@]2([C@H](O2)[C@@H]3[C@@H](CC1)C(=C)C(=O)O3)C

InChIKey

KTEXNACQROZXEV-PVLRGYAZSA-N

InChI

InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1

🔗 External References

HERB DB

HBIN038876 ↗

PubChem CID

7251185 ↗

SymMap

17112

TCMID

16663

TCM-ID

11954

🔍 Raw view — every non-empty column on this row (29 fields)

name

Parthenolide

common names

20554-84-1; (-)-Parthenolide; MFCD00134592; CHEBI:7939; PARTHENOLIDE [MI]; 2RDB26I5ZB; PARTHENOLIDE [USP-RS]; PARTHENOLIDE [WHO-DD]; CHEMBL465158

herb ingredient id

HBIN038876

canonical smiles

CC1=CCCC2(C(O2)C3C(CC1)C(=C)C(=O)O3)C

isomeric smiles

C/C/1=C\CC[C@@]2([C@H](O2)[C@@H]3[C@@H](CC1)C(=C)C(=O)O3)C

inchi

InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1

inchikey

KTEXNACQROZXEV-PVLRGYAZSA-N

mol wt

248.3220

num h acceptors

num h donors

mol logp

2.7620

num rotatable bonds

drug likeness

0.286

symmap mol id

17112

tcmid ingredient id

16663

tcm id ingredient id

11954

pubchem cid

7251185

📋 Clinical Trials

1 · subject of clinical study

NCT00133341 Clinical Evaluation of the 3 Allergens: Methyldibromoglutharonitrile, Parthenoli

→ Allergic Contact Dermatitis

📚 PubMed References

12 · cited research

PMID 31078744 Parthenolide, a feverfew-derived phytochemical, ameliorates obesity and obesity-

Pharmacol Res

PMID 28965856 Pharmacological evidence for the bone-autonomous contribution of the NFκB/β-cate

Cancer Lett

PMID 26821066 The clerodane diterpene casearin J induces apoptosis of T-ALL cells through SERC

Cell Death Dis

PMID 25553117 Parthenolide inhibits cancer stem-like side population of nasopharyngeal carcino

Theranostics

PMID 24387758 Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung c

J Exp Clin Cancer Res

PMID 23933184 Parthenolide inhibits nociception and neurogenic vasodilatation in the trigemino

Pain

PMID 23674500 KEAP1 is a redox sensitive target that arbitrates the opposing radiosensitive ef

Cancer Res

PMID 23318959 Inhibition of intracellular dipeptidyl peptidases 8 and 9 enhances parthenolide'

Leukemia

PMID 22155272 Bcl-XL, but not Bcl-2, can protect human B-lymphoma cell lines from parthenolide

Cancer Lett

PMID 21719790 The inflammatory cytokines TWEAK and TNFα reduce renal klotho expression through

J Am Soc Nephrol

PMID 21223972 Parthenolide inhibits STAT3 signaling and attenuates angiotensin II-induced left

J Mol Cell Cardiol

PMID 31497910 Parthenolide ameliorates intracerebral hemorrhage-induced brain injury in rats

Phytother Res

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables