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Ingredient
44,598
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Gene Target
15,695
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Disease
30,467
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Evidence
23,295
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases
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⚗️ Ingredient

Pectolinarigenin

Open on HERB 2.0 ↗
0
Clinical Trials
0
Meta-Analyses
3
PubMed References
📋 Sample Trials
None linked yet.
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 27735939
Natural product pectolinarigenin inhibits osteosarcoma growth and metastasis via SHP-1-mediated STAT3 signaling inhibition
Cell Death Dis · 2016
PMID 34500010
Neuroprotective and anti-inflammatory effect of pectolinarigenin, a flavonoid from Amazonian Aegiphila integrifolia (Jacq.), against lipopolysaccharide-induced inflammation in astrocytes via NFκB and MAPK pathways
Food Chem Toxicol · 2021
PMID 35453360
Pectolinarigenin Induces Antioxidant Enzymes through Nrf2/ARE Pathway in HepG2 Cells
Antioxidants (Basel) · 2022
⚗️ All Ingredient data fields for Pectolinarigenin
⚗️ Identity
Name
Pectolinarigenin
Aliases / Synonyms
520-12-7; Pectolinaringenin; 5,7-Dihydroxy-4',6-dimethoxyflavone; 5,7-Dihydroxy-6-methoxy-2-(4-methoxyphenyl)-4-benzopyrone; 5,7-Dihydroxy-6,4'-dimethoxyflavone; 6-methoxyacacetin; 5,7-dihydroxy-6-methoxy-2-(4-methoxyphenyl)chromen-4-one; NSC-106403; 4'-Methylcapillarisin
🧪 Chemistry
Molecular Weight
314.2930
LogP
2.8884
Drug-likeness
0.772
H-Bond Acceptors
6
H-Bond Donors
2
Rotatable Bonds
3
🔬 Structures
Canonical SMILES
COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)OC)O
Isomeric SMILES
COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)OC)O
InChIKey
GPQLHGCIAUEJQK-UHFFFAOYSA-N
InChI
InChI=1S/C17H14O6/c1-21-10-5-3-9(4-6-10)13-7-11(18)15-14(23-13)8-12(19)17(22-2)16(15)20/h3-8,19-20H,1-2H3
🔗 External References
HERB DB
HBIN039031 ↗
PubChem CID
5320438 ↗
CAS Number
520-12-7 ↗
NPASS
NPC156222
TCMID
16743; 14205; 36799
TCMSP
MOL005842; MOL008045
TCM-ID
1997; 24247
🔍 Raw view — every non-empty column on this row (33 fields)
name
Pectolinarigenin
common names
520-12-7; Pectolinaringenin; 5,7-Dihydroxy-4',6-dimethoxyflavone; 5,7-Dihydroxy-6-methoxy-2-(4-methoxyphenyl)-4-benzopyrone; 5,7-Dihydroxy-6,4'-dimethoxyflavone; 6-methoxyacacetin; 5,7-dihydroxy-6-methoxy-2-(4-methoxyphenyl)chromen-4-one; NSC-106403; 4'-Methylcapillarisin
herb ingredient id
HBIN039031
canonical smiles
COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)OC)O
isomeric smiles
COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)OC)O
inchi
InChI=1S/C17H14O6/c1-21-10-5-3-9(4-6-10)13-7-11(18)15-14(23-13)8-12(19)17(22-2)16(15)20/h3-8,19-20H,1-2H3
inchikey
GPQLHGCIAUEJQK-UHFFFAOYSA-N
mol wt
314.2930
num h acceptors
6
num h donors
2
mol logp
2.8884
num rotatable bonds
3
drug likeness
0.772
cas id
520-12-7
tcmid ingredient id
16743; 14205; 36799
tcmsp ingredient id
MOL005842; MOL008045
tcm id ingredient id
1997; 24247
pubchem cid
5320438
npass id
NPC156222
tcmsp mol id
MOL005842
tcmsp molecule id
5842

🌿 Related Herbs

1 · contains this compound
Ephedra
Ma Huang

🧬 Gene / Protein Targets

12 · directly binds these targets
NCOA1
Gene NCOA1
NCOA2
Gene NCOA2
Prostaglandin G/H synthase 1
Prostaglandin G/H synthase 2
Dipeptidyl peptidase IV
Acetylcholinesterase
Ig gamma-1 chain C region
Trypsin-1
Nitric oxide synthase, inducible
Alpha-1B adrenergic receptor
Calmodulin
Sodium channel protein type 5 subunit alpha

🏥 Linked Health Topics

30 · diseases via target pathways
Cardiovascular disease, unspecified
disease
Chronic inflammatory diseases
disease
Alzheimer'S Disease
syndrome
Arthritis
syndrome
Renal Cell Carcinoma
disease
Carpal Tunnel Syndrome
syndrome
Endometriosis
syndrome
Inflammation
phenotype
Meningioma
disease
Myocardial Infarction
syndrome
Peutz-Jeghers Syndrome
syndrome
Malignant Mesothelioma
disease
Colorectal cancer
disease
Cancer, unspecific
disease
Lung Cancer
disease
Osteoarthritis
disease
Breast cancer
disease
Prostate cancer
disease
Rheumatoid arthritis, unspecified
disease
Analgesics
disease
Stroke
disease
Inflammatory diseases
disease
Bladder cancer
disease
Abdominal aortic aneurysm
disease
Adenomatous polyposis
disease
Carcinoma in situ, unspecified
disease
Dysmenorrhea, unspecified
disease
Genitourinary tumors
disease
Gestational hypertension
disease
Oropharyngeal squamous cell carcinoma
disease

📚 PubMed References

3 · cited research
PMID 27735939 Natural product pectolinarigenin inhibits osteosarcoma growth and metastasis via
Cell Death Dis
PMID 34500010 Neuroprotective and anti-inflammatory effect of pectolinarigenin, a flavonoid fr
Food Chem Toxicol
PMID 35453360 Pectolinarigenin Induces Antioxidant Enzymes through Nrf2/ARE Pathway in HepG2 C
Antioxidants (Basel)
How relationships are computed
  • Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
  • Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
  • Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
  • Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
  • Target ↔ Disease: ACTIVE — direct link via target_health_topics
  • Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables