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trials · metas · refs
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⚗️ Ingredient

Perillyl alcohol

Open on HERB 2.0 ↗
5
Clinical Trials
2
Meta-Analyses
4
PubMed References
Top Conditions Studied with Perillyl alcohol
Lymphoma|Unspecified Adult Solid Tumor, Protocol Specific 1 Breast Cancer 1 Cancer treatment Cancer prevention 1 Cancer treatment 1 Prostate Cancer 1 Precancerous Condition 1 Pancreatic Cancer 1
📋 Sample Trials
NCT00608634
Topical Perillyl Alcohol in Treating Patients With Sun Damaged Skin and Actinic Keratoses
Completed · Phase 2
NCT00002862
Perillyl Alcohol in Treating Patients With Refractory Cancer
Completed · Phase 1
NCT00003219
Perillyl Alcohol in Treating Patients With Metastatic Breast Cancer
Completed · Phase 2
📊 Sample Meta-Analyses
CRD42018082207
Limonene, perillyl alcohol, perillic acid and perillaldehyde as anticancer agents: a systematic review
Cancer treatment Cancer prevention
CRD42021255527
Perillyl alcohol for cancer treatment
Cancer treatment
📚 Sample References
PMID 33649109
Perillyl alcohol reduces parasite sequestration and cerebrovascular dysfunction during experimental cerebral malaria
Antimicrob Agents Chemother · 2021
PMID 34929480
Perillyl alcohol inhibits keratinocyte proliferation and attenuates imiquimod-induced psoriasis like skin-inflammation by modulating NF-κB and STAT3 signaling pathways
Int Immunopharmacol · 2021
PMID 35030388
Perillyl alcohol attenuates rheumatoid arthritis via regulating TLR4/NF-κB and Keap1/Nrf2 signaling pathways: A comprehensive study onin-vitro and in-vivo experimental models
Phytomedicine · 2022
⚗️ All Ingredient data fields for Perillyl alcohol
⚗️ Identity
Name
Perillyl alcohol
Aliases / Synonyms
536-59-4; Perilla alcohol; Perillol; Isocarveol; p-Mentha-1,8-dien-7-ol; Hydrocumin alcohol; 1-Cyclohexene-1-methanol, 4-(1-methylethenyl)-; Dihydrocuminyl alcohol; Iso-carveol
🧪 Chemistry
Molecular Weight
152.2370
LogP
2.2813
Drug-likeness
0.602
Oral Bioavailability
46.2390
H-Bond Acceptors
1
H-Bond Donors
1
Rotatable Bonds
2
🔬 Structures
Canonical SMILES
CC(=C)C1CCC(=CC1)CO
Isomeric SMILES
CC(=C)C1CCC(=CC1)CO
InChIKey
NDTYTMIUWGWIMO-UHFFFAOYSA-N
InChI
InChI=1S/C10H16O/c1-8(2)10-5-3-9(7-11)4-6-10/h3,10-11H,1,4-7H2,2H3
🔗 External References
HERB DB
HBIN039240 ↗
PubChem CID
10819 ↗
CAS Number
18457-55-1 ↗
NPASS
NPC148216
HIT
C0087
SymMap
4066
TCMID
16922; 16915
TCMSP
MOL001694
TCM-ID
13392
🔍 Raw view — every non-empty column on this row (34 fields)
name
Perillyl alcohol
common names
536-59-4; Perilla alcohol; Perillol; Isocarveol; p-Mentha-1,8-dien-7-ol; Hydrocumin alcohol; 1-Cyclohexene-1-methanol, 4-(1-methylethenyl)-; Dihydrocuminyl alcohol; Iso-carveol
herb ingredient id
HBIN039240
canonical smiles
CC(=C)C1CCC(=CC1)CO
isomeric smiles
CC(=C)C1CCC(=CC1)CO
inchi
InChI=1S/C10H16O/c1-8(2)10-5-3-9(7-11)4-6-10/h3,10-11H,1,4-7H2,2H3
inchikey
NDTYTMIUWGWIMO-UHFFFAOYSA-N
mol wt
152.2370
num h acceptors
1
num h donors
1
mol logp
2.2813
num rotatable bonds
2
drug likeness
0.602
ob score
46.2390
cas id
18457-55-1
symmap mol id
4066
tcmid ingredient id
16922; 16915
tcmsp ingredient id
MOL001694
tcm id ingredient id
13392
pubchem cid
10819
npass id
NPC148216
hit id
C0087

📋 Clinical Trials

5 · subject of clinical study
NCT00608634 Topical Perillyl Alcohol in Treating Patients With Sun Damaged Skin and Actinic
→ Precancerous Condition
NCT00002862 Perillyl Alcohol in Treating Patients With Refractory Cancer
→ Lymphoma|Unspecified Adult Solid Tumor, Protocol S
NCT00003219 Perillyl Alcohol in Treating Patients With Metastatic Breast Cancer
→ Breast Cancer
NCT00003238 Perillyl Alcohol in Treating Patients With Metastatic Prostate Cancer That Has N
→ Prostate Cancer
NCT00003769 Perillyl Alcohol Followed by Surgery in Treating Patients With Stage II or Stage
→ Pancreatic Cancer

📊 Meta-Analyses

2 · systematic review
CRD42018082207 Limonene, perillyl alcohol, perillic acid and perillaldehyde as anticancer agent
→ Cancer treatment Cancer prevention
CRD42021255527 Perillyl alcohol for cancer treatment
→ Cancer treatment

📚 PubMed References

4 · cited research
PMID 33649109 Perillyl alcohol reduces parasite sequestration and cerebrovascular dysfunction
Antimicrob Agents Chemother
PMID 34929480 Perillyl alcohol inhibits keratinocyte proliferation and attenuates imiquimod-in
Int Immunopharmacol
PMID 35030388 Perillyl alcohol attenuates rheumatoid arthritis via regulating TLR4/NF-κB and K
Phytomedicine
PMID 36070663 Perillyl alcohol attenuates chronic restraint stress aggravated dextran sulfate
Phytomedicine
How relationships are computed
  • Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
  • Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
  • Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
  • Ingredient ↔ Target: empty — needs HERB_ingredient_target import
  • Target ↔ Disease: empty — needs HERB_target_disease import
  • Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables