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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.
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Ingredient
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Gene Target
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Disease
30,467
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Evidence
23,295
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
⚗️ Ingredient
Physostigmine
4
Clinical Trials
1
Meta-Analyses
1
PubMed References
Top Conditions Studied with Physostigmine
📋 Sample Trials
NCT01394445
Pilot Study of Physostigmine-Enhanced Opioid Analgesia
Completed · Phase 3
NCT03013322
Anticholium® Per Se
Completed
NCT03090620
Treatment of Adolescent Antimuscarinic (Anticholinergic) Toxidrome
Completed · Phase 4
📊 Sample Meta-Analyses
CRD42022308519
The effects of physostigmine on need for intubation and ICU admission in adults presenting emergently with antimuscarinic toxicity: A systematic review and meta-analysis
Antimuscarinic toxicity presents when a patient has an excess of an antimuscarin
📚 Sample References
PMID 23142559
TNF-α-induced CXCL8 production by A549 cells: involvement of the non-neuronal cholinergic system
Pharmacol Res · 2013
⚗️ All Ingredient data fields for Physostigmine
⚗️ Identity
Name
Physostigmine
Aliases / Synonyms
Eserine; 57-47-6; Antilirium; Physostol; Esromiotin; (-)-physostigmine; Ezerin; Calabarine; Fysostigmin
🧪 Chemistry
Molecular Weight
275.3520
LogP
1.7739
Drug-likeness
0.848
H-Bond Acceptors
4
H-Bond Donors
1
Rotatable Bonds
1
🔬 Structures
Canonical SMILES
CC12CCN(C1N(C3=C2C=C(C=C3)OC(=O)NC)C)C
Isomeric SMILES
C[C@@]12CCN([C@@H]1N(C3=C2C=C(C=C3)OC(=O)NC)C)C
InChIKey
PIJVFDBKTWXHHD-HIFRSBDPSA-N
InChI
InChI=1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15+/m1/s1
🔗 External References
🔍 Raw view — every non-empty column on this row (30 fields)
name
Physostigmine
common names
Eserine; 57-47-6; Antilirium; Physostol; Esromiotin; (-)-physostigmine; Ezerin; Calabarine; Fysostigmin
herb ingredient id
HBIN039772
canonical smiles
CC12CCN(C1N(C3=C2C=C(C=C3)OC(=O)NC)C)C
isomeric smiles
C[C@@]12CCN([C@@H]1N(C3=C2C=C(C=C3)OC(=O)NC)C)C
inchi
InChI=1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15+/m1/s1
inchikey
PIJVFDBKTWXHHD-HIFRSBDPSA-N
mol wt
275.3520
num h acceptors
4
num h donors
1
mol logp
1.7739
num rotatable bonds
1
drug likeness
0.848
symmap mol id
19436
tcmid ingredient id
31803
tcm id ingredient id
1773
pubchem cid
5983
npass id
NPC284796
🏥 Linked Health Topics
1 · diseases via target pathways📋 Clinical Trials
4 · subject of clinical studyNCT01394445 Pilot Study of Physostigmine-Enhanced Opioid Analgesia
→ Postoperative Pain
NCT03013322 Anticholium® Per Se
→ Shock, Septic|Sepsis|Perioperative Period
NCT03090620 Treatment of Adolescent Antimuscarinic (Anticholinergic) Toxidrome
→ Anticholinergics Toxicity
NCT00608621 Influence of Physostigmine on Patient-Controlled Analgesia (PCA) in Postoperativ
→ Pain
📊 Meta-Analyses
1 · systematic reviewCRD42022308519 The effects of physostigmine on need for intubation and ICU admission in adults
→ Antimuscarinic toxicity presents when a patient ha
📚 PubMed References
1 · cited researchPMID 23142559 TNF-α-induced CXCL8 production by A549 cells: involvement of the non-neuronal ch
Pharmacol Res
How relationships are computed
- Clinical Trials / Meta-Analyses / References: direct foreign-key link via
subject_entity_id(Phase 2d wireup) - Formula ↔ Herbs: text bridge via
formulas.herbs_in_pinyinmatchingherbs.pinyin_name - Herb ↔ Ingredient:
ACTIVE — direct link via
herb_ingredients - Ingredient ↔ Target:
ACTIVE — direct link via
ingredient_targets - Target ↔ Disease:
ACTIVE — direct link via
target_health_topics - Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables