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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Pilocarpine

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Pilocarpine

Presbyopia 6 Dry Mouth 5 Open-angle Glaucoma 1 Cystic Fibrosis 1 Presbyopia patients of all age group 40-60 year in which top 1 Near Vision 1 Breast Cancer|Vaginal Dryness 1 Presbyopia is an age-related insufficiency of accommodation 1 Incontinence 1 Oral mucositis and xerostomia. 1 Healthy Subjects 1 Dryness of the mouth can be presented as either having a low 1

📋 Sample Trials

NCT00438048

A Comparison of Orally Pilocarpine and Artificial Saliva in Xerostomy Treatment

Completed · Phase 4

NCT00618059

Bioequivalency Study of 7.5 mg Pilocarpine Under Fed Conditions

Completed

NCT00656513

Acupuncture-Like Transcutaneous Electrical Nerve Stimulation (ALTENS) or Pilocarpine in Treating Early Dry Mouth in Patients Undergoing Radiation Therapy for Head and Neck Cancer

Completed · Phase 2|Phase 3

📊 Sample Meta-Analyses

CRD42022362181

The use of chlorhexidine and pilocarpine for oral mucosal epithelium, exposed to ionizing radiation.

Oral mucositis and xerostomia.

CRD42016047993

Treatment with pilocarpine for Sjogren's syndrome: protocol for a systematic review

Sjogren's syndrome is one of the most prevalent systemic autoimmune disease.Beca

CRD42018085592

Comparison of the efficacy of the conventional administration of pilocarpine and other forms in the treatment of xerostomy in patients with Sjögren's Syndrome. Systematic review

Sjögren's syndrome is a systemic autoimmune disease that is characterized by the

📚 Sample References

PMID 32260203

Pilocarpine Induced Behavioral and Biochemical Alterations in Chronic Seizure-Like Condition in Adult Zebrafish

Int J Mol Sci · 2020

⚗️ All Ingredient data fields for Pilocarpine

⚗️ Identity

Name

Pilocarpine

Aliases / Synonyms

92-13-7; Pilokarpin; Pilocarpol; Syncarpine; Pilocarpin; Ocusert pilo; Spersacarpine; Pilokarpol; (+)-Pilocarpine

🧪 Chemistry

Molecular Weight

208.2610

LogP

1.1618

Drug-likeness

0.7

H-Bond Acceptors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CCC1C(COC1=O)CC2=CN=CN2C

Isomeric SMILES

CC[C@H]1[C@H](COC1=O)CC2=CN=CN2C

InChIKey

QCHFTSOMWOSFHM-WPRPVWTQSA-N

InChI

InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1

🔗 External References

HERB DB

HBIN039919 ↗

PubChem CID

5910 ↗

TCMID

17346

TCM-ID

1745

🔍 Raw view — every non-empty column on this row (28 fields)

name

Pilocarpine

common names

92-13-7; Pilokarpin; Pilocarpol; Syncarpine; Pilocarpin; Ocusert pilo; Spersacarpine; Pilokarpol; (+)-Pilocarpine

herb ingredient id

HBIN039919

canonical smiles

CCC1C(COC1=O)CC2=CN=CN2C

isomeric smiles

CC[C@H]1[C@H](COC1=O)CC2=CN=CN2C

inchi

InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1

inchikey

QCHFTSOMWOSFHM-WPRPVWTQSA-N

mol wt

208.2610

num h acceptors

num h donors

mol logp

1.1618

num rotatable bonds

drug likeness

0.7

tcmid ingredient id

17346

tcm id ingredient id

1745

pubchem cid

5910

🏥 Linked Health Topics

5 · studied for these conditions (text bridge)

📋 Clinical Trials

12 · subject of clinical study

NCT00438048 A Comparison of Orally Pilocarpine and Artificial Saliva in Xerostomy Treatment

→ Primary Sjogren|Secondary Sjogren|Xerostomia

NCT00618059 Bioequivalency Study of 7.5 mg Pilocarpine Under Fed Conditions

→ Dry Mouth

NCT00656513 Acupuncture-Like Transcutaneous Electrical Nerve Stimulation (ALTENS) or Pilocar

→ Head and Neck Cancer|Xerostomia

NCT01036035 Effects of Novel Combinations of Tolterodine/Pilocarpine on Pharmacokinetics (PK

→ Incontinence

NCT01627626 Effect of 0.1% Pilocarpine Mouthwash on Xerostomia

→ Xerostomia

NCT01690052 Efficacy of Cevimeline Versus Pilocarpine in the Secretion of Saliva

→ Dry Mouth

NCT02447315 A Study to Investigate the Effect of Oral Doses of Pilocarpine on Salivary Secre

→ Healthy Subjects

NCT02754570 The Diurnal and Nocturnal Effect of Pilocarpine on Intraocular Pressure and Ocul

→ Glaucoma, Open-angle|Hypertension, Ocular

NCT03804268 Efficacy Study of Pilocarpine HCl Ophthalmic Solution (AGN-190584) in Participan

→ Presbyopia

NCT03857542 A Phase 3 Efficacy Study of Pilocarpine HCl Ophthalmic Solution (AGN-190584) in

→ Presbyopia

NCT03933631 Pilocarpine Use After Kahook Goniotomy

→ Glaucoma

NCT04732195 Pilocarpine Microneedles for Sweat Induction (PMN-SI)

→ Cystic Fibrosis

📊 Meta-Analyses

9 · systematic review

CRD42022362181 The use of chlorhexidine and pilocarpine for oral mucosal epithelium, exposed to

→ Oral mucositis and xerostomia.

CRD42016047993 Treatment with pilocarpine for Sjogren's syndrome: protocol for a systematic rev

→ Sjogren's syndrome is one of the most prevalent sy

CRD42018085592 Comparison of the efficacy of the conventional administration of pilocarpine and

→ Sjögren's syndrome is a systemic autoimmune diseas

CRD42020218407 Safety and Efficacy of Pilocarpine, Cevimeline and Diquafosol compared to Artifi

→ Dry eye disease (DED) is a condition that affects

CRD42021282073 Evaluation of the effect of pilocarpine mouthwash on salivary flow rate and symp

→ Xerostomia is a subjective sensation of dry mouth

CRD42022307256 Efficacy and safety of topical pilocarpine in the management of presbyopia: A sy

→ Presbyopia patients of all age group 40-60 year in

CRD42023405612 Efficacy of oral pilocarpine or cevimiline for the treatment of dry eye in patie

→ Sjögren's syndrome (SS) is a common autoimmune dis

CRD42023414893 The efficacy of the topical pilocarpine in adult patients with xerostomia&#xff1a

→ Dryness of the mouth can be presented as either ha

CRD42023418875 Systematic review and meta-analysis on the efficacy and safety of Pilocarpine (1

→ Presbyopia is an age-related insufficiency of acco

📚 PubMed References

1 · cited research

PMID 32260203 Pilocarpine Induced Behavioral and Biochemical Alterations in Chronic Seizure-Li

Int J Mol Sci

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables