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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.
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Herb
6,826
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Ingredient
44,598
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Gene Target
15,695
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🏥
Disease
30,467
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Evidence
23,295
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
⚗️ Ingredient
Piperine
4
Clinical Trials
3
Meta-Analyses
24
PubMed References
Top Conditions Studied with Piperine
Deglutition Disorders 1
Bladder Spasm|Malignant Neoplasm|Pain|Urinary Urgency 1
We will study any disease connected to oxidative stress 1
Pharmacokinetic activity of conventional drugs co-administer 1
In this review, the effect of the curcumin and piperine comb 1
Prostate Cancer|Multiple Myeloma|Smoldering Multiple Myeloma 1
Focus of the Study: Normal Volunteers 1
📋 Sample Trials
NCT02598726
Curcumin and Piperine in Reducing Inflammation for Ureteral Stent-Induced Symptoms in Patients With Cancer
Active_Not_Recruiting · Phase 1
NCT04731844
Curcumin and Piperine in Patients on Surveillance for Monoclonal Gammopathy, Smoldering Myeloma or Prostate Cancer
Recruiting · Phase 2
NCT01324089
Resveratrol With or Without Piperine to Enhance Plasma Levels of Resveratrol
Completed
📊 Sample Meta-Analyses
CRD42020205056
Effects of Curcumin associated with piperine supplementation on oxidative stress biomarkers based on a randomized placebo-controlled trial
We will study any disease connected to oxidative stress
CRD42022320034
Cytochrome P450 mediated clinical pharmacokinetic alterations of Co-administered conventional drugs with Piperine- A :systematic review and meta-analysis.
Pharmacokinetic activity of conventional drugs co-administered with piperine.
CRD42023475116
The effect of the curcumin and piperine combination on glycemic control and liver function: A systematic review and Meta-Analysis of randomized controlled trial
In this review, the effect of the curcumin and piperine combination on glycemic
📚 Sample References
PMID 29378605
Piperine ameliorates SCA17 neuropathology by reducing ER stress
Mol Neurodegener · 2018
PMID 28330809
Piperine Attenuates Pathological Cardiac Fibrosis Via PPAR-γ/AKT Pathways
EBioMedicine · 2017
PMID 26297981
Inhibition of intestinal chloride secretion by piperine as a cellular basis for the anti-secretory effect of black peppers
Pharmacol Res · 2015
⚗️ All Ingredient data fields for Piperine
⚗️ Identity
Name
Piperine
Aliases / Synonyms
94-62-2; 1-Piperoylpiperidine; Piperin; Bioperine; 7780-20-3; Piperoylpiperidine; FEMA No. 2909; (E,E)-1-piperoylpiperidine; Piperidine, 1-piperoyl-, (E,E)-
🧪 Chemistry
Molecular Weight
285.3430
LogP
2.9972
Drug-likeness
0.633
Oral Bioavailability
42.5170
H-Bond Acceptors
3
Rotatable Bonds
3
🔬 Structures
Canonical SMILES
C1CCN(CC1)C(=O)C=CC=CC2=CC3=C(C=C2)OCO3
Isomeric SMILES
C1CCN(CC1)C(=O)/C=C/C=C/C2=CC3=C(C=C2)OCO3
InChIKey
MXXWOMGUGJBKIW-YPCIICBESA-N
InChI
InChI=1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+
🔗 External References
HERB DB
PubChem CID
CAS Number
NPASS
NPC136330
HIT
C0315
SymMap
114
TCMID
17437
TCMSP
MOL001592
TCM-ID
1621
🔍 Raw view — every non-empty column on this row (34 fields)
name
Piperine
common names
94-62-2; 1-Piperoylpiperidine; Piperin; Bioperine; 7780-20-3; Piperoylpiperidine; FEMA No. 2909; (E,E)-1-piperoylpiperidine; Piperidine, 1-piperoyl-, (E,E)-
herb ingredient id
HBIN040071
canonical smiles
C1CCN(CC1)C(=O)C=CC=CC2=CC3=C(C=C2)OCO3
isomeric smiles
C1CCN(CC1)C(=O)/C=C/C=C/C2=CC3=C(C=C2)OCO3
inchi
InChI=1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+
inchikey
MXXWOMGUGJBKIW-YPCIICBESA-N
mol wt
285.3430
num h acceptors
3
num h donors
0
mol logp
2.9972
num rotatable bonds
3
drug likeness
0.633
ob score
42.5170
cas id
94-62-2
symmap mol id
114
tcmid ingredient id
17437
tcmsp ingredient id
MOL001592
tcm id ingredient id
1621
pubchem cid
638024
npass id
NPC136330
hit id
C0315
🏥 Linked Health Topics
1 · diseases via target pathways📋 Clinical Trials
4 · subject of clinical studyNCT02598726 Curcumin and Piperine in Reducing Inflammation for Ureteral Stent-Induced Sympto
→ Bladder Spasm|Malignant Neoplasm|Pain|Urinary Urge
NCT04731844 Curcumin and Piperine in Patients on Surveillance for Monoclonal Gammopathy, Smo
→ Prostate Cancer|Multiple Myeloma|Smoldering Multip
NCT01324089 Resveratrol With or Without Piperine to Enhance Plasma Levels of Resveratrol
→ Focus of the Study: Normal Volunteers
NCT01383694 Effect Of Piperine In Patients With Oropharyngeal Dysphagia
→ Deglutition Disorders
📊 Meta-Analyses
3 · systematic reviewCRD42020205056 Effects of Curcumin associated with piperine supplementation on oxidative stress
→ We will study any disease connected to oxidative s
CRD42022320034 Cytochrome P450 mediated clinical pharmacokinetic alterations of Co-administered
→ Pharmacokinetic activity of conventional drugs co-
CRD42023475116 The effect of the curcumin and piperine combination on glycemic control and live
→ In this review, the effect of the curcumin and pip
📚 PubMed References
12 · cited researchPMID 29378605 Piperine ameliorates SCA17 neuropathology by reducing ER stress
Mol Neurodegener
PMID 28330809 Piperine Attenuates Pathological Cardiac Fibrosis Via PPAR-γ/AKT Pathways
EBioMedicine
PMID 26297981 Inhibition of intestinal chloride secretion by piperine as a cellular basis for
Pharmacol Res
PMID 24326980 Effect of oral piperine on the swallow response of patients with oropharyngeal d
J Gastroenterol
PMID 31989711 The anti-anaphylactoid effects of Piperine through regulating MAS-related G prot
Phytother Res
PMID 32335165 Piperine ameliorated memory impairment and myelin damage in lysolecethin induced
Life Sci
PMID 32353424 Natural product piperine alleviates experimental allergic encephalomyelitis in m
Biochem Pharmacol
PMID 32477284 Piperine Impedes Biofilm Formation and Hyphal Morphogenesis of Candida albicans
Front Microbiol
PMID 32721999 Resveratrol, Curcumin and Piperine Alter Human Glyoxalase 1 in MCF-7 Breast Canc
Int J Mol Sci
PMID 33219747 Piperine protects against pyroptosis in myocardial ischaemia/reperfusion injury
J Cell Mol Med
PMID 33667521 Piperine protects against pancreatic β-cell dysfunction by alleviating macrophag
Life Sci
PMID 33737876 Downregulation of Candidate Gene Expression and Neuroprotection by Piperine in S
Front Pharmacol
How relationships are computed
- Clinical Trials / Meta-Analyses / References: direct foreign-key link via
subject_entity_id(Phase 2d wireup) - Formula ↔ Herbs: text bridge via
formulas.herbs_in_pinyinmatchingherbs.pinyin_name - Herb ↔ Ingredient:
ACTIVE — direct link via
herb_ingredients - Ingredient ↔ Target:
ACTIVE — direct link via
ingredient_targets - Target ↔ Disease:
ACTIVE — direct link via
target_health_topics - Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables