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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Pregnenolone

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Pregnenolone

Schizophrenia 3 Schizophrenia|Schizoaffective Disorder 2 Healthy 2 Stress Disorders, Post-Traumatic 1 Autism Spectrum Disorder|Autism 1 Schizophrenia|Schizophreniform Disorder|Schizoaffective Diso 1 Alcohol Use Disorder 1 Perceived Social Isolation 1 Marijuana Dependence 1 Major Depressive Disorder 1 Schizophrenia, schizoaffective disorer or other psychotic di 1 As a chronic psychiatric disorder, schizophrenia affects the 1

📋 Sample Trials

NCT00174889

Pregnenolone in the Management of Schizophrenia Patients

Completed · Phase 1

NCT00560781

Targeting Cognition in PTSD: Pregnenolone Augmentation of SSRIs

Completed

NCT00560937

Pilot Study of Pregnenolone Augmentation Targeting Cognitive Symptoms in Persistently Symptomatic Patients With Schizophrenia

Completed

📊 Sample Meta-Analyses

CRD42017081355

Adjunctive pregnenolone therapy for the treatment of schizophrenia and other psychotic disorders

Schizophrenia, schizoaffective disorer or other psychotic disorder.

CRD42021233396

Adjunctive pregnenolone for schizophrenia: a meta-analysis of randomized controlled trials

As a chronic psychiatric disorder, schizophrenia affects the worldwide populatio

📚 Sample References

PMID 24385629

Pregnenolone can protect the brain from cannabis intoxication

Science · 2014

PMID 28220044

Pregnenolone blocks cannabinoid-induced acute psychotic-like states in mice

Mol Psychiatry · 2017

PMID 30853321

Activation of the cation channel TRPM3 in perivascular nerves induces vasodilation of resistance arteries

J Mol Cell Cardiol · 2019

⚗️ All Ingredient data fields for Pregnenolone

⚗️ Identity

Name

Pregnenolone

Aliases / Synonyms

145-13-1; 3beta-Hydroxypregn-5-en-20-one; Arthenolone; Pregnetan; Pregneton; Pregnolon; Prenolon; Regnosone; Skinostelon

🧪 Chemistry

Molecular Weight

316.4850

LogP

4.5153

Drug-likeness

0.722

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC(=O)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C

Isomeric SMILES

CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C

InChIKey

ORNBQBCIOKFOEO-QGVNFLHTSA-N

InChI

InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1

🔗 External References

HERB DB

HBIN040687 ↗

PubChem CID

8955 ↗

NPASS

NPC221758

HIT

C0323

TCMID

17791

🔍 Raw view — every non-empty column on this row (29 fields)

name

Pregnenolone

common names

145-13-1; 3beta-Hydroxypregn-5-en-20-one; Arthenolone; Pregnetan; Pregneton; Pregnolon; Prenolon; Regnosone; Skinostelon

herb ingredient id

HBIN040687

canonical smiles

CC(=O)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C

isomeric smiles

CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C

inchi

InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1

inchikey

ORNBQBCIOKFOEO-QGVNFLHTSA-N

mol wt

316.4850

num h acceptors

num h donors

mol logp

4.5153

num rotatable bonds

drug likeness

0.722

tcmid ingredient id

17791

pubchem cid

8955

npass id

NPC221758

hit id

C0323

🏥 Linked Health Topics

5 · studied for these conditions (text bridge)

Substance Withdrawal Syndrome

disease

Major Depressive Disorder

disease

📋 Clinical Trials

12 · subject of clinical study

NCT00174889 Pregnenolone in the Management of Schizophrenia Patients

→ Schizophrenia

NCT00560781 Targeting Cognition in PTSD: Pregnenolone Augmentation of SSRIs

→ Stress Disorders, Post-Traumatic

NCT00560937 Pilot Study of Pregnenolone Augmentation Targeting Cognitive Symptoms in Persist

→ Schizophrenia

NCT00615511 Efficacy of Pregnenolone in Patients With Schizophrenia

→ Schizophrenia|Schizoaffective Disorder

NCT00623506 Adjunctive Pregnenolone in Veterans With Mild TBI

→ Traumatic Brain Injury

NCT00728728 Pregnenolone for Cognitive and Negative Symptoms in Schizophrenia

→ Schizophrenia|Schizoaffective Disorder

NCT00847600 Pregnenolone Augmentation in the Treatment of Patients With Recent-Onset Schizop

→ Schizophrenia|Schizophreniform Disorder|Schizoaffe

NCT00900900 The Effects of One-Time Pregnenolone, Dehydroepiandrosterone (DHEA), or Placebo

→ Substance Withdrawal Syndrome

NCT01409096 Study Using Pregnenolone to Treat Bipolar Depression

→ Bipolar Disorder|Major Depressive Disorder

NCT01881737 A Study of Pregnenolone in the Treatment of Individuals With Autism

→ Autistic Disorder

NCT02439814 Pregnenolone and Marijuana Dependence

→ Marijuana Dependence

NCT02627508 Pilot Trial of Pregnenolone in Autism

→ Autism Spectrum Disorder|Autism

📊 Meta-Analyses

2 · systematic review

CRD42017081355 Adjunctive pregnenolone therapy for the treatment of schizophrenia and other psy

→ Schizophrenia, schizoaffective disorer or other ps

CRD42021233396 Adjunctive pregnenolone for schizophrenia: a meta-analysis of randomized control

→ As a chronic psychiatric disorder, schizophrenia a

📚 PubMed References

7 · cited research

PMID 24385629 Pregnenolone can protect the brain from cannabis intoxication

Science

PMID 28220044 Pregnenolone blocks cannabinoid-induced acute psychotic-like states in mice

Mol Psychiatry

PMID 30853321 Activation of the cation channel TRPM3 in perivascular nerves induces vasodilati

J Mol Cell Cardiol

PMID 25781227 Pregnenolone sulfate normalizes schizophrenia-like behaviors in dopamine transpo

Transl Psychiatry

PMID 23955365 Pregnenolone activates CLIP-170 to promote microtubule growth and cell migration

Nat Chem Biol

PMID 21108630 Stereo-selective inhibition of transient receptor potential TRPC5 cation channel

Br J Pharmacol

PMID 32292342 Pregnenolone Inhibits Osteoclast Differentiation and Protects Against Lipopolysa

Front Pharmacol

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables