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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Progesterone

Open on HERB 2.0 ↗

158

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Progesterone

Infertility 18 Preterm Birth 9 Menopause 5 Pharmacokinetics 4 Preterm Delivery 3 Traumatic Brain Injury 3 Healthy 3 Tobacco Use Disorder 3 Infertility, Female 3 Preterm Labor 3 Threatened Miscarriage 3 Female Infertility 3

📋 Sample Trials

NCT00000295

Progesterone Treatment in Female Smokers - 12

Completed · Phase 2

NCT00029536

Progesterone vs Placebo Therapy for Women With Epilepsy

Completed · Phase 3

NCT00086177

Vaginal Progesterone to Reduce the Risk of Another Preterm Birth

Completed · Phase 3

📊 Sample Meta-Analyses

CRD42022358986

Progesterone luteal support and pregnancy outcomes in IVF: a systematic review and network meta-analysis

Luteal support in the prevention of unsuccessful IVF/ICSI, as reflected from cli

CRD42022342120

Response rates of MMR-deficient endometrial lesions to fertility-sparing progesterone treatment: a systematic review

The systematic review includes patients with endometrial cancers or pre-cancerou

CRD42016033946

Combinations of progesterone, cerclage and/or pessary for primary prevention of preterm birth: a systematic review and meta-analysis

Preterm birth is a major public health problem, and is the leading cause of infa

📚 Sample References

PMID 32165211

Effects of progesterone on the cell number of gliomaspheres derived from human glioblastoma cell lines

Life Sci · 2020

PMID 32170571

Long-Lasting Actions of Progesterone Protect the Neonatal Brain Following Hypoxia-Ischemia

Cell Mol Neurobiol · 2020

PMID 32335121

Progesterone treatment following traumatic brain injury in the 11-day-old rat attenuates cognitive deficits and neuronal hyperexcitability in adolescence

Exp Neurol · 2020

⚗️ All Ingredient data fields for Progesterone

⚗️ Identity

Name

Progesterone

Aliases / Synonyms

57-83-0; Pregn-4-ene-3,20-dione; Agolutin; Crinone; 4-Pregnene-3,20-dione; Prometrium; Utrogestan; Progestin; Luteol

🧪 Chemistry

Molecular Weight

314.4690

LogP

4.7235

Drug-likeness

0.701

Oral Bioavailability

13.6570

H-Bond Acceptors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C

Isomeric SMILES

CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C

InChIKey

RJKFOVLPORLFTN-LEKSSAKUSA-N

InChI

InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1

🔗 External References

HERB DB

PubChem CID

CAS Number

DrugBank

NPASS

NPC307176

HIT

C0325

SymMap

630

TCMID

17887

TCMSP

MOL006214

TCM-ID

1639

🔍 Raw view — every non-empty column on this row (35 fields)

name

Progesterone

common names

57-83-0; Pregn-4-ene-3,20-dione; Agolutin; Crinone; 4-Pregnene-3,20-dione; Prometrium; Utrogestan; Progestin; Luteol

herb ingredient id

HBIN040799

canonical smiles

CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C

isomeric smiles

CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C

inchi

InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1

inchikey

RJKFOVLPORLFTN-LEKSSAKUSA-N

mol wt

314.4690

num h acceptors

num h donors

mol logp

4.7235

num rotatable bonds

drug likeness

0.701

ob score

13.6570

cas id

257630-50-5

symmap mol id

630

tcmid ingredient id

17887

tcmsp ingredient id

MOL006214

tcm id ingredient id

1639

pubchem cid

5994

drugbank id

DB00396

npass id

NPC307176

hit id

C0325

🏥 Linked Health Topics

12 · studied for these conditions (text bridge)

Polycystic Ovary Syndrome

syndrome

Premature Birth

phenotype

Cervical Intraepithelial Neoplasia

Progesterone Resistance

syndrome

Postmenopausal Endometrium

syndrome

Cannabis Use

disease

📋 Clinical Trials

12 · subject of clinical study

NCT00000295 Progesterone Treatment in Female Smokers - 12

→ Tobacco Use Disorder

NCT00029536 Progesterone vs Placebo Therapy for Women With Epilepsy

→ Epilepsy

NCT00086177 Vaginal Progesterone to Reduce the Risk of Another Preterm Birth

→ Pregnancy

NCT00218257 Progesterone for the Treatment of Cocaine Dependence - 1

→ Cocaine Abuse|Cocaine-Related Disorders

NCT00247169 Vaginal Progesterone in the Treatment of Cervical Dysplasia Grade I and II

→ Cervical Intraepithelial Neoplasia

NCT00271206 Effect of Progesterone on Smoking Behavior in Male and Female Smokers

→ Tobacco Use Disorder

NCT00329914 Does Progesterone Prevent Very Preterm Delivery in Twin Pregnancies?

→ Preterm Delivery

NCT00343265 Vaginal Progesterone Versus Placebo in Multiple Pregnancy

→ Preterm Birth

NCT00377923 Endometrial Effects of Daily Progesterone s.c. 25 and 50 Mg Aqueous Formulation

→ Healthy

NCT00455741 Postmenopausal Women Estrogen and Progesterone Infusion

→ Postmenopause|Aging

NCT00480402 Natural Progesterone and Preterm Birth in Twins

→ Preterm Birth

NCT00530582 Progesterone Reduces Wakefulness in Sleep EEG and Has no Effect on Cognition in

→ Healthy|Postmenopausal

📊 Meta-Analyses

12 · systematic review

CRD42022358986 Progesterone luteal support and pregnancy outcomes in IVF: a systematic review a

→ Luteal support in the prevention of unsuccessful I

CRD42022342120 Response rates of MMR-deficient endometrial lesions to fertility-sparing progest

→ The systematic review includes patients with endom

CRD42016033946 Combinations of progesterone, cerclage and/or pessary for primary prevention of

→ Preterm birth is a major public health problem, an

CRD42016043565 The comparative efficacy of cervical pessary, cerclage, vaginal and parenteral p

→ Preterm birth, short cervix, prevention of preterm

CRD42019117678 Progesterone treatment in patients undergoing cervical cerclage: a meta-analysis

→ Both progesterone and cervical cerclage are potent

CRD42019129296 Progesterone administration for the prevention of preterm birth and risk of deve

→ The preventive effect of progestogens was already

CRD42021239228 The effect of vaginal progesterone on preventing preterm birth and target popula

→ Preterm birth (PTB), which occurs in about 12% of

CRD42021252327 Efficacy of cerclage, progesterone and pessary in preventing preterm birth in wo

→ Existing evidence demonstrates an increased risk o

CRD42022327812 A systematic review and meta-analysis of the effectiveness of combined progester

→ Preterm birth is the leading cause of neonatal dea

CRD42022360203 Meta analysis of the effect of phloroglucinol combined with progesterone in the

→ Threatened miscarriage

CRD42018095246 Oral progesterone for the prevention of recurrent preterm birth: a systematic re

→ Preterm birth.

CRD42017074070 Should a threshold of 1% or more vs 10% or more of cells showing oestrogen recep

→ Breast cancer.

📚 PubMed References

10 · cited research

PMID 32165211 Effects of progesterone on the cell number of gliomaspheres derived from human g

Life Sci

PMID 32170571 Long-Lasting Actions of Progesterone Protect the Neonatal Brain Following Hypoxi

Cell Mol Neurobiol

PMID 32335121 Progesterone treatment following traumatic brain injury in the 11-day-old rat at

Exp Neurol

PMID 32466385 Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhance

Int J Mol Sci

PMID 32689704 Benefits of progesterone on brain immaturity and white matter injury induced by

J Thorac Cardiovasc Surg

PMID 33047378 Progesterone, via yes-associated protein, promotes cardiomyocyte proliferation a

Cell Prolif

PMID 33216902 Administration of Exogenous Progesterone Protects Against Brucella abortus Infec

J Infect Dis

PMID 33505354 Progesterone's Effects on Cognitive Performance of Male Mice Are Independent of

Front Endocrinol (Lausanne)

PMID 33633700 Progesterone Suppresses Neisseria gonorrhoeae-Induced Inflammation Through Inhib

Front Microbiol

PMID 34912332 Progesterone Aggravates Lung Fibrosis in a Mouse Model of Systemic Sclerosis

Front Immunol

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables