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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Pterostilbene

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Pterostilbene

Amyotrophic Lateral Sclerosis 2 AKI 1 Muscle Injury 1 Hyperlipidemia|Blood Pressure|Oxidative Stress 1 Atypical Endometrial Hyperplasia|Endometrial Carcinoma 1

📋 Sample Trials

NCT01267227

Effect of Pterostilbene on Cholesterol, Blood Pressure and Oxidative Stress

Completed · Phase 2|Phase 3

NCT03671811

Megestrol Acetate With or Without Pterostilbene in Treating Patients With Endometrial Cancer Undergoing Hysterectomy

Active_Not_Recruiting · Phase 2

NCT03754842

Effect of Nicotinamide Riboside and Pterostilbene Supplementation on Muscle Regeneration in Elderly Humans

Completed

📊 Sample Meta-Analyses

None linked yet.

📚 Sample References

PMID 31138785

Inhibition of eIF2α dephosphorylation accelerates pterostilbene-induced cell death in human hepatocellular carcinoma cells in an ER stress and autophagy-dependent manner

Cell Death Dis · 2019

PMID 30632134

Pterostilbene prevents hepatocyte epithelial-mesenchymal transition in fructose-induced liver fibrosis through suppressing miR-34a/Sirt1/p53 and TGF-β1/Smads signalling

Br J Pharmacol · 2019

PMID 28327179

Pterostilbene prevents AKT-ERK axis-mediated polymerization of surface fibronectin on suspended lung cancer cells independently of apoptosis and suppresses metastasis

J Hematol Oncol · 2017

⚗️ All Ingredient data fields for Pterostilbene

⚗️ Identity

Name

Pterostilbene

Aliases / Synonyms

537-42-8; trans-pterostilbene; 4-(3,5-Dimethoxystyryl)phenol; (E)-4-(3,5-dimethoxystyryl)phenol; 4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenol; 18259-15-9; 3',5'-Dimethoxy-4-stilbenol; pterostilbene, (E)-; 4-[(E)-2-(3,5-dimethoxyphenyl)vinyl]phenol

🧪 Chemistry

Molecular Weight

256.3010

LogP

3.5798

Drug-likeness

0.85

Oral Bioavailability

77.5430

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

COC1=CC(=CC(=C1)C=CC2=CC=C(C=C2)O)OC

Isomeric SMILES

COC1=CC(=CC(=C1)/C=C/C2=CC=C(C=C2)O)OC

InChIKey

VLEUZFDZJKSGMX-ONEGZZNKSA-N

InChI

InChI=1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+

🔗 External References

HERB DB

HBIN041217 ↗

PubChem CID

5281727 ↗

CAS Number

537-42-8 ↗

NPASS

NPC180508

HIT

C0336

SymMap

12801

TCMID

18149

TCMSP

MOL011980

TCM-ID

18733

🔍 Raw view — every non-empty column on this row (34 fields)

name

Pterostilbene

common names

herb ingredient id

HBIN041217

canonical smiles

COC1=CC(=CC(=C1)C=CC2=CC=C(C=C2)O)OC

isomeric smiles

COC1=CC(=CC(=C1)/C=C/C2=CC=C(C=C2)O)OC

inchi

InChI=1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+

inchikey

VLEUZFDZJKSGMX-ONEGZZNKSA-N

mol wt

256.3010

num h acceptors

num h donors

mol logp

3.5798

num rotatable bonds

drug likeness

0.85

ob score

77.5430

cas id

537-42-8

symmap mol id

12801

tcmid ingredient id

18149

tcmsp ingredient id

MOL011980

tcm id ingredient id

18733

pubchem cid

5281727

npass id

NPC180508

hit id

C0336

🏥 Linked Health Topics

1 · studied for these conditions (text bridge)

Amyotrophic Lateral Sclerosis

syndrome

📋 Clinical Trials

6 · subject of clinical study

NCT01267227 Effect of Pterostilbene on Cholesterol, Blood Pressure and Oxidative Stress

→ Hyperlipidemia|Blood Pressure|Oxidative Stress

NCT03671811 Megestrol Acetate With or Without Pterostilbene in Treating Patients With Endome

→ Atypical Endometrial Hyperplasia|Endometrial Carci

NCT03754842 Effect of Nicotinamide Riboside and Pterostilbene Supplementation on Muscle Rege

→ Muscle Injury

NCT04562831 The NO-ALS Study: a Trial of Nicotinamide/pterostilbene Supplement in ALS.

→ Amyotrophic Lateral Sclerosis

NCT05095571 A Trial of Nicotinamide/Pterostilbene Supplement in ALS: The NO-ALS Extension St

→ Amyotrophic Lateral Sclerosis

NCT04342975 Protection From Acute Kidney Injury (AKI) With Basis™ Treatment

→ AKI

📚 PubMed References

12 · cited research

PMID 31138785 Inhibition of eIF2α dephosphorylation accelerates pterostilbene-induced cell dea

Cell Death Dis

PMID 30632134 Pterostilbene prevents hepatocyte epithelial-mesenchymal transition in fructose-

Br J Pharmacol

PMID 28327179 Pterostilbene prevents AKT-ERK axis-mediated polymerization of surface fibronect

J Hematol Oncol

PMID 27364556 Activation of the c-Met Pathway Mobilizes an Inflammatory Network in the Brain M

Cancer Res

PMID 26651028 Pterostilbene Decreases the Antioxidant Defenses of Aggressive Cancer Cells In V

Antioxid Redox Signal

PMID 25845487 Topical treatment with pterostilbene, a natural phytoalexin, effectively protect

Free Radic Biol Med

PMID 25746774 Pterostilbene and allopurinol reduce fructose-induced podocyte oxidative stress

Free Radic Biol Med

PMID 24417315 Therapeutic potential of pterostilbene against pancreatic beta-cell apoptosis me

Br J Pharmacol

PMID 32377661 Pterostilbene prevents LPS-induced early pulmonary fibrosis by suppressing oxida

Food Funct

PMID 32490497 Pterostilbene alleviates cerebral ischemia and reperfusion injury in rats by mod

Food Funct

PMID 32582712 Induction of Autophagy by Pterostilbene Contributes to the Prevention of Renal F

Front Cell Dev Biol

PMID 32831997 Pterostilbene Attenuates Cocultured BV-2 Microglial Inflammation-Mediated SH-SY5

Oxid Med Cell Longev

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables