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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Puerarin

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Puerarin

Rheumatoid Arthritis 1 Alcohol Abuse 1 Type 2 diabetes mellitus (T2DM) and its vascular complicatio 1 In the United States, at least 5 to 27 of every 100000 peopl 1 Diabetic peripheral neuropathy (DPN) is one of the complicat 1 Diabetic neuropathy is nerve damage caused by diabetes. When 1 Chronic heart failure：It is due to myocardial infarction, ca 1 Acute heart failure is a common disease in clinical practice 1

📋 Sample Trials

NCT00854724

Puerarin Effects on Alcohol Drinking

Completed · Phase 2

NCT02254655

The Effect of Puerarin Injection on Carotid Intima-Media Thickness in Patients With Rheumatoid Arthritis

Completed · Phase 2

📊 Sample Meta-Analyses

CRD42011001555

Puerarin for the management of diabetic peripheral neuropathy: a systematic review and meta-analysis

Diabetic neuropathy is nerve damage caused by diabetes. When it affects the arms

CRD42023378752

Efficacy and safety of injectable puerarin in treating type 2 diabetes mellitus and its microvascular and macrovascular complications: a systematic review of randomized controlled trials

Type 2 diabetes mellitus (T2DM) and its vascular complications.

CRD42015014434

Effects of puerarin in addition to western medicine for the management of diabetic peripheral neuropathy: a meta-analysis and meta-regression

Diabetic peripheral neuropathy (DPN) is one of the complications of diabetes me

📚 Sample References

PMID 22609359

Puerarin inhibits the retinal pericyte apoptosis induced by advanced glycation end products in vitro and in vivo by inhibiting NADPH oxidase-related oxidative stress

Free Radic Biol Med · 2012

PMID 32361558

Puerarin ameliorates hyperglycemia in HFD diabetic mice by promoting β-cell neogenesis via GLP-1R signaling activation

Phytomedicine · 2020

PMID 32399049

Puerarin Relieved Compression-Induced Apoptosis and Mitochondrial Dysfunction in Human Nucleus Pulposus Mesenchymal Stem Cells via the PI3K/Akt Pathway

Stem Cells Int · 2020

⚗️ All Ingredient data fields for Puerarin

⚗️ Identity

Name

Puerarin

Aliases / Synonyms

3681-99-0; Kakonein; Daidzein-8-C-glucoside; 7-hydroxy-3-(4-hydroxyphenyl)-8-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-4H-chromen-4-one; Puerarin 80 mm; CHEBI:8633; Daidzein 8-c-glucoside; 7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one; NPI 031G

🧪 Chemistry

Molecular Weight

416.3820

LogP

0.3861

Drug-likeness

0.355

Oral Bioavailability

24.0310

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3C4C(C(C(C(O4)CO)O)O)O)O)O

Isomeric SMILES

C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O)O

InChIKey

HKEAFJYKMMKDOR-VPRICQMDSA-N

InChI

InChI=1S/C21H20O9/c22-7-14-17(26)18(27)19(28)21(30-14)15-13(24)6-5-11-16(25)12(8-29-20(11)15)9-1-3-10(23)4-2-9/h1-6,8,14,17-19,21-24,26-28H,7H2/t14-,17-,18+,19-,21+/m1/s1

🔗 External References

HERB DB

PubChem CID

CAS Number

DrugBank

NPASS

NPC124478

HIT

C0337

SymMap

321

TCMID

18166

TCMSP

MOL012297

TCM-ID

1468

🔍 Raw view — every non-empty column on this row (35 fields)

name

Puerarin

common names

herb ingredient id

HBIN041253

canonical smiles

C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3C4C(C(C(C(O4)CO)O)O)O)O)O

isomeric smiles

C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O)O

inchi

InChI=1S/C21H20O9/c22-7-14-17(26)18(27)19(28)21(30-14)15-13(24)6-5-11-16(25)12(8-29-20(11)15)9-1-3-10(23)4-2-9/h1-6,8,14,17-19,21-24,26-28H,7H2/t14-,17-,18+,19-,21+/m1/s1

inchikey

HKEAFJYKMMKDOR-VPRICQMDSA-N

mol wt

416.3820

num h acceptors

num h donors

mol logp

0.3861

num rotatable bonds

drug likeness

0.355

ob score

24.0310

cas id

3681-99-0

symmap mol id

321

tcmid ingredient id

18166

tcmsp ingredient id

MOL012297

tcm id ingredient id

1468

pubchem cid

5281807

drugbank id

DB12290

npass id

NPC124478

hit id

C0337

🏥 Linked Health Topics

2 · diseases via target pathways

📋 Clinical Trials

2 · subject of clinical study

NCT00854724 Puerarin Effects on Alcohol Drinking

→ Alcohol Abuse

NCT02254655 The Effect of Puerarin Injection on Carotid Intima-Media Thickness in Patients W

→ Rheumatoid Arthritis

📊 Meta-Analyses

8 · systematic review

CRD42011001555 Puerarin for the management of diabetic peripheral neuropathy: a systematic revi

→ Diabetic neuropathy is nerve damage caused by diab

CRD42023378752 Efficacy and safety of injectable puerarin in treating type 2 diabetes mellitus

→ Type 2 diabetes mellitus (T2DM) and its vascular c

CRD42015014434 Effects of puerarin in addition to western medicine for the management of diabet

→ Diabetic peripheral neuropathy (DPN) is one of the

CRD42022371583 Efficacy and safety of Puerarin injection on Chronic Heart Failure: A Systematic

→ Chronic heart failure：It is due to myocardial infa

CRD42021244370 Anti-inflammatory and antioxidant activity of puerarin in diabetic nephropathy:

CRD42021254910 Preclinical evidence of puerarin on cardiac fibrosis: A systematic review and me

CRD42023408998 6 kinds of traditional Chinese medicine injections for Sudden Deafness: A protoc

→ In the United States, at least 5 to 27 of every 10

CRD42023448829 Reticular meta-analysis of different Chinese medicine injection combined with co

→ Acute heart failure is a common disease in clinica

📚 PubMed References

12 · cited research

PMID 22609359 Puerarin inhibits the retinal pericyte apoptosis induced by advanced glycation e

Free Radic Biol Med

PMID 32361558 Puerarin ameliorates hyperglycemia in HFD diabetic mice by promoting β-cell neog

Phytomedicine

PMID 32399049 Puerarin Relieved Compression-Induced Apoptosis and Mitochondrial Dysfunction in

Stem Cells Int

PMID 32457606 Puerarin Increases Survival and Protects Against Organ Injury by Suppressing NF-

Front Pharmacol

PMID 32504066 Puerarin ameliorated pressure overload-induced cardiac hypertrophy in ovariectom

Acta Pharmacol Sin

PMID 32526286 Puerarin ameliorates retinal ganglion cell damage induced by retinal ischemia/re

Life Sci

PMID 32763437 Puerarin suppresses MPP+/MPTP-induced oxidative stress through an Nrf2-dependent

Food Chem Toxicol

PMID 32896108 Puerarin inhibits titanium particle-induced osteolysis and RANKL-induced osteocl

J Cell Mol Med

PMID 33141084 Comparative study of oral and intranasal puerarin for prevention of brain injury

Int J Pharm

PMID 33141989 Puerarin sensitized K562/ADR cells by inhibiting NF-κB pathway and inducing auto

Phytother Res

PMID 33242606 Up-regulation of thioredoxin system by puerarin inhibits lipid uptake in macroph

Free Radic Biol Med

PMID 33350519 Puerarin inhibits the development of osteoarthritis through antiinflammatory and

Phytother Res

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables