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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Qinghaosu

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Qinghaosu

Falciparum malaria, treatment efficacy, pregnancy 2 P. vivax malaria. 1 Schizophrenia 1 Non-falciparum malaria. 1 Covid19 1 Malaria is a leading killer disease with over 400,000 deaths 1 Uncomplicated plasmodium falciparum malaria 1 Malaria in pregnancy (MIP) refers to the occurrence of a mal 1 This review covers parenteral or rectal antimalaria administ 1 The World Health Organization recommends artemisinin-based c 1 Falciparum malaria, PLHIV, treatment efficacy of ACTs 1 The systematic review focuses on malaria treatment. It conta 1

📋 Sample Trials

NCT00753506

Artemisinin to Reduce The Symptoms of Schizophrenia

Completed

NCT01391403

Artemisinin With Risperidone for First-Episode and Drug-Naive Schizophrenia

Completed · Phase 3

NCT05004753

A Study to Evaluate the Safety and Efficacy of Artemisinin- a Herbal Supplement on COVID-19 Subjects

Completed · Phase 4

📊 Sample Meta-Analyses

CRD42017054808

A systematic literature review of the efficacy of quinine-based and artemisinin-based treatment for uncomplicated falciparum malaria during pregnancy (all trimesters) and assessment of methods

Falciparum malaria, treatment efficacy, pregnancy

CRD42018082711

Resistance against artemisinin-based combination therapies (ACT)

Plasmodium Falciparum Malaria

CRD42018089860

<div>A systematic review of the efficacy of artemisinin-based combination therapy (ACT) in people living with HIV (PLHIV) diagnosed with uncomplicated Plasmodium falciparum malaria in Africa<br /></div>

Falciparum malaria, PLHIV, treatment efficacy of ACTs

📚 Sample References

PMID 31094238

Artemisinin alleviates atherosclerotic lesion by reducing macrophage inflammation via regulation of AMPK/NF-κB/NLRP3 inflammasomes pathway

J Drug Target · 2020

PMID 31947602

Direct Activation of TRPC3 Channels by the Antimalarial Agent Artemisinin

Cells · 2020

PMID 32360948

Artemisinin inhibits the replication of flaviviruses by promoting the type I interferon production

Antiviral Res · 2020

⚗️ All Ingredient data fields for Qinghaosu

⚗️ Identity

Name

Qinghaosu

Aliases / Synonyms

artemisinin; Qinghaosu; 63968-64-9; Arteannuin; Huanghuahaosu; Artemisinine; Artemisine; (+)-Artemisinin; Artemisinina; Artemisininum

🧪 Chemistry

Molecular Weight

282.3360

LogP

2.3949

Drug-likeness

0.504

H-Bond Acceptors

🔬 Structures

Canonical SMILES

CC1CCC2C(C(=O)OC3C24C1CCC(O3)(OO4)C)C

Isomeric SMILES

C[C@@H]1CC[C@H]2[C@H](C(=O)O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)C

InChIKey

BLUAFEHZUWYNDE-NNWCWBAJSA-N

InChI

InChI=1S/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3/t8-,9-,10+,11+,13-,14-,15-/m1/s1

🔗 External References

HERB DB

HBIN041440 ↗

PubChem CID

68827 ↗

NPASS

NPC30443

TCM-ID

23749

🔍 Raw view — every non-empty column on this row (28 fields)

name

Qinghaosu

common names

artemisinin; Qinghaosu; 63968-64-9; Arteannuin; Huanghuahaosu; Artemisinine; Artemisine; (+)-Artemisinin; Artemisinina; Artemisininum

herb ingredient id

HBIN041440

canonical smiles

CC1CCC2C(C(=O)OC3C24C1CCC(O3)(OO4)C)C

isomeric smiles

C[C@@H]1CC[C@H]2[C@H](C(=O)O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)C

inchi

InChI=1S/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3/t8-,9-,10+,11+,13-,14-,15-/m1/s1

inchikey

BLUAFEHZUWYNDE-NNWCWBAJSA-N

mol wt

282.3360

num h acceptors

num h donors

mol logp

2.3949

num rotatable bonds

drug likeness

0.504

tcm id ingredient id

23749

pubchem cid

68827

npass id

NPC30443

🏥 Linked Health Topics

1 · diseases via target pathways

Schizophrenia

disease

📋 Clinical Trials

3 · subject of clinical study

NCT00753506 Artemisinin to Reduce The Symptoms of Schizophrenia

→ Schizophrenia|Schizoaffective Disorder

NCT01391403 Artemisinin With Risperidone for First-Episode and Drug-Naive Schizophrenia

→ Schizophrenia

NCT05004753 A Study to Evaluate the Safety and Efficacy of Artemisinin- a Herbal Supplement

→ Covid19

📊 Meta-Analyses

12 · systematic review

CRD42017054808 A systematic literature review of the efficacy of quinine-based and artemisinin-

→ Falciparum malaria, treatment efficacy, pregnancy

CRD42018082711 Resistance against artemisinin-based combination therapies (ACT)

→ Plasmodium Falciparum Malaria

CRD42018089860 <div>A systematic review of the efficacy of artemisinin-based combination therap

→ Falciparum malaria, PLHIV, treatment efficacy of A

CRD42018090521 A systematic review of the efficacy of Artemisinin-based combination therapy (AC

→ Falciparum malaria, obesity, overweight, efficacy

CRD42018104013 The efficacy of artemisinin-based and quinine-based treatments for uncomplicated

→ Falciparum malaria, treatment efficacy, pregnancy

CRD42019133366 An individual patient data meta-analysis of parasite clearance half-life (PC1/2)

→ Uncomplicated plasmodium falciparum malaria

CRD42020218190 What are the comparative efficacy and safety of artemisinin derivatives in the t

→ This review covers parenteral or rectal antimalari

CRD42021229882 The effect of artemisinin-based drugs vs. non-artemisinin-based drugs on gametop

CRD42021282209 Effects of Artemisinin derivatives on tumor cell apoptosis: a systematic review

→ Cancer is a complex, multifactorial disease, with

CRD42018084651 Dihydroartemisinin-piperaquine versus sulphadoxine-pyrimethamine for malaria pre

→ Malaria in pregnancy (MIP) refers to the occurrenc

CRD42014009103 Efficacy and safety of artemisinin combination therapy (ACT) for non-falciparum

→ Non-falciparum malaria.

CRD42015032371 Pooled analysis for the assessment of the safety of exposure to artemisinin deri

📚 PubMed References

12 · cited research

PMID 31094238 Artemisinin alleviates atherosclerotic lesion by reducing macrophage inflammatio

J Drug Target

PMID 31947602 Direct Activation of TRPC3 Channels by the Antimalarial Agent Artemisinin

Cells

PMID 32360948 Artemisinin inhibits the replication of flaviviruses by promoting the type I int

Antiviral Res

PMID 32535079 Artemisinin attenuates early renal damage on diabetic nephropathy rats through s

Life Sci

PMID 32765947 Artemisinin Improved Neuronal Functions in Alzheimer's Disease Animal Model 3xtg

Aging Dis

PMID 33453127 Artemisinin inhibits TLR4 signaling by targeting co-receptor MD2 in microglial B

J Neurochem

PMID 33758353 Artemisinin improves neurocognitive deficits associated with sepsis by activatin

Acta Pharmacol Sin

PMID 33811898 Artemisinin protects DPSC from hypoxia and TNF-α mediated osteogenesis impairmen

Life Sci

PMID 34567410 Artemisinin Reverses Glucocorticoid-Induced Injury in Bone Marrow-Derived Mesenc

Oxid Med Cell Longev

PMID 34900697 Artemisinin Mediates Its Tumor-Suppressive Activity in Hepatocellular Carcinoma

Front Oncol

PMID 35757500 Artemisinin and Its Derivate Alleviate Pulmonary Hypertension and Vasoconstricti

Oxid Med Cell Longev

PMID 35902802 Artemisinin relieves osteoarthritis by activating mitochondrial autophagy throug

Cell Mol Biol Lett

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables