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Ingredient
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Gene Target
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Disease
30,467
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Evidence
23,295
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases
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⚗️ Ingredient

Rosmarinic acid

Open on HERB 2.0 ↗
1
Clinical Trials
0
Meta-Analyses
23
PubMed References
Top Conditions Studied with Rosmarinic acid
Nasal Polyps 1
📋 Sample Trials
NCT00465543
Mint Tea for the Treatment of Nasal Polyps
Completed · Phase 2
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 29555592
Rosmarinic acid attenuates β-amyloid-induced oxidative stress via Akt/GSK-3β/Fyn-mediated Nrf2 activation in PC12 cells
Free Radic Biol Med · 2018
PMID 29367637
Rosmarinic acid attenuates cardiac fibrosis following long-term pressure overload via AMPKα/Smad3 signaling
Cell Death Dis · 2018
PMID 28923043
Rosmarinic acid induces rabbit articular chondrocyte differentiation by decreases matrix metalloproteinase-13 and inflammation by upregulating cyclooxygenase-2 expression
J Biomed Sci · 2017
⚗️ All Ingredient data fields for Rosmarinic acid
⚗️ Identity
Name
Rosmarinic acid
Aliases / Synonyms
20283-92-5; Rosemary acid; Labiatenic acid; Rosmarinicacid; Labiatic acid; (R)-rosmarinic acid; trans-Rosmarinic acid; Rosemaric acid; Rosmarinate
🧪 Chemistry
Molecular Weight
360.3180
LogP
1.7613
Drug-likeness
0.298
Oral Bioavailability
1.3800
H-Bond Acceptors
7
H-Bond Donors
5
Rotatable Bonds
6
🔬 Structures
Canonical SMILES
C1=CC(=C(C=C1CC(C(=O)O)OC(=O)C=CC2=CC(=C(C=C2)O)O)O)O
Isomeric SMILES
C1=CC(=C(C=C1C[C@H](C(=O)O)OC(=O)/C=C/C2=CC(=C(C=C2)O)O)O)O
InChIKey
DOUMFZQKYFQNTF-WUTVXBCWSA-N
InChI
InChI=1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+/t16-/m1/s1
🔗 External References
HERB DB
HBIN042438 ↗
PubChem CID
5281792 ↗
CAS Number
20283-92-5 ↗
NPASS
NPC61
HIT
C0374
SymMap
316
TCMID
23178
TCMSP
MOL011865
TCM-ID
1087
🔍 Raw view — every non-empty column on this row (34 fields)
name
Rosmarinic acid
common names
20283-92-5; Rosemary acid; Labiatenic acid; Rosmarinicacid; Labiatic acid; (R)-rosmarinic acid; trans-Rosmarinic acid; Rosemaric acid; Rosmarinate
herb ingredient id
HBIN042438
canonical smiles
C1=CC(=C(C=C1CC(C(=O)O)OC(=O)C=CC2=CC(=C(C=C2)O)O)O)O
isomeric smiles
C1=CC(=C(C=C1C[C@H](C(=O)O)OC(=O)/C=C/C2=CC(=C(C=C2)O)O)O)O
inchi
InChI=1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+/t16-/m1/s1
inchikey
DOUMFZQKYFQNTF-WUTVXBCWSA-N
mol wt
360.3180
num h acceptors
7
num h donors
5
mol logp
1.7613
num rotatable bonds
6
drug likeness
0.298
ob score
1.3800
cas id
20283-92-5
symmap mol id
316
tcmid ingredient id
23178
tcmsp ingredient id
MOL011865
tcm id ingredient id
1087
pubchem cid
5281792
npass id
NPC61
hit id
C0374

🏥 Linked Health Topics

1 · diseases via target pathways
Nasal Polyps
syndrome

📋 Clinical Trials

1 · subject of clinical study
NCT00465543 Mint Tea for the Treatment of Nasal Polyps
→ Nasal Polyps

📚 PubMed References

12 · cited research
PMID 29555592 Rosmarinic acid attenuates β-amyloid-induced oxidative stress via Akt/GSK-3β/Fyn
Free Radic Biol Med
PMID 29367637 Rosmarinic acid attenuates cardiac fibrosis following long-term pressure overloa
Cell Death Dis
PMID 28923043 Rosmarinic acid induces rabbit articular chondrocyte differentiation by decrease
J Biomed Sci
PMID 25936352 Rosmarinic acid up-regulates the noise-activated Nrf2/HO-1 pathway and protects
Free Radic Biol Med
PMID 23414442 Rosmarinic acid protects against experimental diabetes with cerebral ischemia: r
J Neuroinflammation
PMID 31719255 Rosmarinic acid ameliorates hypoxia/ischemia induced cognitive deficits and prom
Neural Regen Res
PMID 31985119 Rosmarinic acid reverses non-small cell lung cancer cisplatin resistance by acti
Phytother Res
PMID 32088353 Rosmarinic acid exerts an anticancer effect on osteosarcoma cells by inhibiting
Phytomedicine
PMID 32331258 Lemon Balm and Its Constituent, Rosmarinic Acid, Alleviate Liver Damage in an An
Nutrients
PMID 32397909 Rosmarinic acid exhibits broad anti-enterovirus A71 activity by inhibiting the i
Emerg Microbes Infect
PMID 32760434 Bidirect effects from cisplatin combine with rosmarinic acid (RA) or hot water e
Chin Med
PMID 32824269 p-Cymene and Rosmarinic Acid Ameliorate TNBS-Induced Intestinal Inflammation Upk
Int J Mol Sci
How relationships are computed
  • Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
  • Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
  • Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
  • Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
  • Target ↔ Disease: ACTIVE — direct link via target_health_topics
  • Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables