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Ingredient
44,598
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Gene Target
15,695
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Disease
30,467
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Evidence
23,295
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
⚗️ Ingredient
Sarcosine
8
Clinical Trials
1
Meta-Analyses
2
PubMed References
Top Conditions Studied with Sarcosine
📋 Sample Trials
NCT00328276
Sarcosine (N-Methylglycine) Monotherapy for Schizophrenia
Completed · Phase 2
NCT00491569
Sarcosine or D-Serine Add-on Treatment for Chronic Schizophrenia
Completed · Phase 2
NCT00538070
A Study of the Effects of Sarcosine on Symptoms and Brain Glycine Levels in People With Schizophrenia
Completed
📊 Sample Meta-Analyses
CRD42019141455
Sarcosine as an add-on treatment to antipsychotic medication for people with schizophrenia and other psychotic disorders: a systematic review and meta-analysis of randomized controlled trials
Schizophrenia is an enduring mental disorder, with a prevalence of 1 % worldwide
📚 Sample References
PMID 31753028
Sarcosine promotes trafficking of dendritic cells and improves efficacy of anti-tumor dendritic cell vaccines via CXC chemokine family signaling
J Immunother Cancer · 2019
PMID 32581708
Sarcosine Suppresses Epileptogenesis in Rats With Effects on Hippocampal DNA Methylation
Front Mol Neurosci · 2020
⚗️ All Ingredient data fields for Sarcosine
⚗️ Identity
Name
Sarcosine
Aliases / Synonyms
107-97-1; N-methylglycine; Sarcosinic acid; 2-(methylamino)acetic acid; Methylglycine; Glycine, N-methyl-; N-Methylaminoacetic acid; Sarcosin; Methylaminoacetic acid
🧪 Chemistry
Molecular Weight
89.0940
LogP
-0.7096
Drug-likeness
0.47
H-Bond Acceptors
2
H-Bond Donors
2
Rotatable Bonds
2
🔬 Structures
Canonical SMILES
CNCC(=O)O
Isomeric SMILES
CNCC(=O)O
InChIKey
FSYKKLYZXJSNPZ-UHFFFAOYSA-N
InChI
InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6)
🔗 External References
🔍 Raw view — every non-empty column on this row (28 fields)
name
Sarcosine
common names
107-97-1; N-methylglycine; Sarcosinic acid; 2-(methylamino)acetic acid; Methylglycine; Glycine, N-methyl-; N-Methylaminoacetic acid; Sarcosin; Methylaminoacetic acid
herb ingredient id
HBIN043148
canonical smiles
CNCC(=O)O
isomeric smiles
CNCC(=O)O
inchi
InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6)
inchikey
FSYKKLYZXJSNPZ-UHFFFAOYSA-N
mol wt
89.0940
num h acceptors
2
num h donors
2
mol logp
-0.7096
num rotatable bonds
2
drug likeness
0.47
tcmid ingredient id
19345
pubchem cid
1088
npass id
NPC169186
🏥 Linked Health Topics
3 · diseases via target pathways📋 Clinical Trials
8 · subject of clinical studyNCT00328276 Sarcosine (N-Methylglycine) Monotherapy for Schizophrenia
→ Schizophrenias|Psychoses|Psychotic Disorders|Schiz
NCT00491569 Sarcosine or D-Serine Add-on Treatment for Chronic Schizophrenia
→ Schizophrenias|Psychoses|Psychotic Disorders|Schiz
NCT00538070 A Study of the Effects of Sarcosine on Symptoms and Brain Glycine Levels in Peop
→ Schizophrenia
NCT00977353 N-methylglycine (Sarcosine) Treatment for Depression
→ Major Depressive Disorder|Depression|Major Depress
NCT01503359 Effect of Sarcosine on Symptomatology, Quality of Life, Oxidative Stress and Glu
→ Schizophrenia
NCT04975100 Evaluation of Efficacy and Safety of add-on Sarcosine in Patients With Major Dep
→ Major Depressive Disorder
NCT01031927 N-methyl Glycine (Sarcosine) for the Treatment of Obsessive Compulsive Disorder
→ Obsessive Compulsive Disorder
NCT02462447 Carbon-11 Labeled Sarcosine in Prostate Cancer
→ Prostate Cancer
📊 Meta-Analyses
1 · systematic reviewCRD42019141455 Sarcosine as an add-on treatment to antipsychotic medication for people with sch
→ Schizophrenia is an enduring mental disorder, with
📚 PubMed References
2 · cited researchPMID 31753028 Sarcosine promotes trafficking of dendritic cells and improves efficacy of anti-
J Immunother Cancer
PMID 32581708 Sarcosine Suppresses Epileptogenesis in Rats With Effects on Hippocampal DNA Met
Front Mol Neurosci
How relationships are computed
- Clinical Trials / Meta-Analyses / References: direct foreign-key link via
subject_entity_id(Phase 2d wireup) - Formula ↔ Herbs: text bridge via
formulas.herbs_in_pinyinmatchingherbs.pinyin_name - Herb ↔ Ingredient:
ACTIVE — direct link via
herb_ingredients - Ingredient ↔ Target:
ACTIVE — direct link via
ingredient_targets - Target ↔ Disease:
ACTIVE — direct link via
target_health_topics - Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables