Relationship Graph Explorer

Follow the connections

Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

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🧪

Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Spd

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Spd

Healthy Diet|Mortality 1 Depression|Healthy 1 Peri-implant Mucositis|Mucositis Oral 1 Hypertension 1 Healthy Subjects 1

📋 Sample Trials

NCT03378843

Spermidine Intake and All-cause Mortality

Completed

NCT04405388

Spermidine Anti-Hypertension Study

Recruiting · Phase 3

NCT04823806

An Exploratory Clinical Study on Autophagy and Multi-level Molecular Profiling During Spermidine Supplementation

Active_Not_Recruiting

📊 Sample Meta-Analyses

None linked yet.

📚 Sample References

None linked yet.

⚗️ All Ingredient data fields for Spd

⚗️ Identity

Name

Spd

Aliases / Synonyms

spermidine; 124-20-9; 1,5,10-Triazadecane; 4-Azaoctamethylenediamine; Spermidin; N1-(3-Aminopropyl)butane-1,4-diamine; 4-Azaoctane-1,8-diamine; N-(3-aminopropyl)butane-1,4-diamine; N'-(3-aminopropyl)butane-1,4-diamine; 1,4-Butanediamine, N-(3-aminopropyl)-

🧪 Chemistry

Molecular Weight

145.2500

LogP

-0.3363

Drug-likeness

0.43

Oral Bioavailability

45.4100

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C(CCNCCCN)CN

Isomeric SMILES

C(CCNCCCN)CN

InChIKey

ATHGHQPFGPMSJY-UHFFFAOYSA-N

InChI

InChI=1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2

🔗 External References

HERB DB

HBIN044482 ↗

PubChem CID

1102 ↗

CAS Number

124-20-9 ↗

NPASS

NPC193536

HIT

C0412

SymMap

9959

TCMSP

MOL008724

🔍 Raw view — every non-empty column on this row (32 fields)

name

Spd

common names

herb ingredient id

HBIN044482

canonical smiles

C(CCNCCCN)CN

isomeric smiles

C(CCNCCCN)CN

inchi

InChI=1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2

inchikey

ATHGHQPFGPMSJY-UHFFFAOYSA-N

mol wt

145.2500

num h acceptors

num h donors

mol logp

-0.3363

num rotatable bonds

drug likeness

0.43

ob score

45.4100

cas id

124-20-9

symmap mol id

9959

tcmsp ingredient id

MOL008724

pubchem cid

1102

npass id

NPC193536

hit id

C0412

🏥 Linked Health Topics

1 · diseases via target pathways

Hypertension

disease

📋 Clinical Trials

5 · subject of clinical study

NCT03378843 Spermidine Intake and All-cause Mortality

→ Healthy Diet|Mortality

NCT04405388 Spermidine Anti-Hypertension Study

→ Hypertension

NCT04823806 An Exploratory Clinical Study on Autophagy and Multi-level Molecular Profiling D

→ Depression|Healthy

NCT06017219 Bioavailability of Spermidine in Healthy Males

→ Healthy Subjects

NCT05926557 Treatment of Peri-implant Mucositis by Application of a Spermidine-based Gel

→ Peri-implant Mucositis|Mucositis Oral

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables