Relationship Graph Explorer
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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.
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Herb
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Ingredient
44,598
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Gene Target
15,695
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Disease
30,467
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Evidence
23,295
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
⚗️ Ingredient
Spermine
1
Clinical Trials
0
Meta-Analyses
2
PubMed References
Top Conditions Studied with Spermine
📋 Sample Trials
NCT04004091
Prenatal Administration of Spermine Promotes Maturation of Premature Fetal Gut Epithelial Tight Junction: Experimental Study on Fetal Rabbit
Completed · Early_Phase 1
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 32234613
Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor
Redox Biol · 2020
PMID 36348350
Elevation of spermine remodels immunosuppressive microenvironment through driving the modification of PD-L1 in hepatocellular carcinoma
Cell Commun Signal · 2022
⚗️ All Ingredient data fields for Spermine
⚗️ Identity
Name
Spermine
Aliases / Synonyms
71-44-3; musculamine; neuridine; gerontine; Spermin; 4,9-Diaza-1,12-dodecanediamine; N,N'-Bis(3-aminopropyl)-1,4-butanediamine; Spermine, puriss; Diaminopropyltetramethylenediamine
🧪 Chemistry
Molecular Weight
202.3460
LogP
-0.3566
Drug-likeness
0.345
H-Bond Acceptors
4
H-Bond Donors
4
Rotatable Bonds
11
🔬 Structures
Canonical SMILES
C(CCNCCCN)CNCCCN
Isomeric SMILES
C(CCNCCCN)CNCCCN
InChIKey
PFNFFQXMRSDOHW-UHFFFAOYSA-N
InChI
InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
🔗 External References
🔍 Raw view — every non-empty column on this row (30 fields)
name
Spermine
common names
71-44-3; musculamine; neuridine; gerontine; Spermin; 4,9-Diaza-1,12-dodecanediamine; N,N'-Bis(3-aminopropyl)-1,4-butanediamine; Spermine, puriss; Diaminopropyltetramethylenediamine
herb ingredient id
HBIN044494
canonical smiles
C(CCNCCCN)CNCCCN
isomeric smiles
C(CCNCCCN)CNCCCN
inchi
InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
inchikey
PFNFFQXMRSDOHW-UHFFFAOYSA-N
mol wt
202.3460
num h acceptors
4
num h donors
4
mol logp
-0.3566
num rotatable bonds
11
drug likeness
0.345
symmap mol id
17771
tcmid ingredient id
20131
pubchem cid
1103
npass id
NPC95589
hit id
C0413
📋 Clinical Trials
1 · subject of clinical studyNCT04004091 Prenatal Administration of Spermine Promotes Maturation of Premature Fetal Gut E
→ Premature Birth|NEC
📚 PubMed References
2 · cited researchPMID 32234613 Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p5
Redox Biol
PMID 36348350 Elevation of spermine remodels immunosuppressive microenvironment through drivin
Cell Commun Signal
How relationships are computed
- Clinical Trials / Meta-Analyses / References: direct foreign-key link via
subject_entity_id(Phase 2d wireup) - Formula ↔ Herbs: text bridge via
formulas.herbs_in_pinyinmatchingherbs.pinyin_name - Herb ↔ Ingredient:
ACTIVE — direct link via
herb_ingredients - Ingredient ↔ Target:
ACTIVE — direct link via
ingredient_targets - Target ↔ Disease:
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target_health_topics - Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables