Relationship Graph Explorer

Follow the connections

Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

🌿

Herb

→

→

→

→

🧪

Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Stigmasterol

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

📋 Sample Trials

None linked yet.

📊 Sample Meta-Analyses

None linked yet.

📚 Sample References

PMID 24107941

Plant sterols the better cholesterol in Alzheimer's disease? A mechanistical study

J Neurosci · 2013

PMID 24107776

Phytosterols promote liver injury and Kupffer cell activation in parenteral nutrition-associated liver disease

Sci Transl Med · 2013

PMID 31759199

Stigmasterol stimulates transintestinal cholesterol excretion independent of liver X receptor activation in the small intestine

J Nutr Biochem · 2020

⚗️ All Ingredient data fields for Stigmasterol

⚗️ Identity

Name

Stigmasterol

Aliases / Synonyms

83-48-7; Stigmasterin; beta-Stigmasterol; Stigmasta-5,22-dien-3beta-ol; (24S)-5,22-Stigmastadien-3beta-ol; Stigmasta-5,22-dien-3-beta-ol; UNII-99WUK5D0Y8; Stigmasta-5,22-dien-3-ol, (3beta,22E)-; Delta5-Stigmasterol

🧪 Chemistry

Molecular Weight

412.7020

LogP

7.8008

Drug-likeness

0.457

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CCC(C=CC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)C(C)C

Isomeric SMILES

CC[C@H](/C=C/[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C)C(C)C

InChIKey

HCXVJBMSMIARIN-PHZDYDNGSA-N

InChI

InChI=1S/C29H48O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h8-10,19-21,23-27,30H,7,11-18H2,1-6H3/b9-8+/t20-,21-,23+,24+,25-,26+,27+,28+,29-/m1/s1

🔗 External References

HERB DB

HBIN044918 ↗

PubChem CID

5280794 ↗

NPASS

NPC113733

TCMID

20353

TCMSP

MOL000449; MOL002045

TCM-ID

747

🔍 Raw view — every non-empty column on this row (32 fields)

name

Stigmasterol

common names

herb ingredient id

HBIN044918

canonical smiles

CCC(C=CC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)C(C)C

isomeric smiles

CC[C@H](/C=C/[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C)C(C)C

inchi

InChI=1S/C29H48O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h8-10,19-21,23-27,30H,7,11-18H2,1-6H3/b9-8+/t20-,21-,23+,24+,25-,26+,27+,28+,29-/m1/s1

inchikey

HCXVJBMSMIARIN-PHZDYDNGSA-N

mol wt

412.7020

num h acceptors

num h donors

mol logp

7.8008

num rotatable bonds

drug likeness

0.457

tcmid ingredient id

20353

tcmsp ingredient id

MOL000449; MOL002045

tcm id ingredient id

747

pubchem cid

5280794

npass id

NPC113733

tcmsp mol id

MOL000449

tcmsp molecule id

449

🌿 Related Herbs

1 · contains this compound

Ephedra

Ma Huang

🧬 Gene / Protein Targets

30 · directly binds these targets

PGR

Gene PGR

NCOA1

Gene NCOA1

NCOA2

Gene NCOA2

Prostaglandin G/H synthase 1

Prostaglandin G/H synthase 2

Muscarinic acetylcholine receptor M2

Gamma-aminobutyric acid receptor subunit alpha-1

Ig gamma-1 chain C region

mRNA of PKA Catalytic Subunit C-alpha

Muscarinic acetylcholine receptor M1

Sodium-dependent noradrenaline transporter

Alpha-1B adrenergic receptor

Aldose reductase

Sodium channel protein type 5 subunit alpha

Beta-2 adrenergic receptor

Retinoic acid receptor RXR-alpha

Amine oxidase [flavin-containing] B

Urokinase-type plasminogen activator

Muscarinic acetylcholine receptor M3

5-hydroxytryptamine 2A receptor

Alpha-1A adrenergic receptor

Gamma-aminobutyric-acid receptor alpha-3 subunit

Neuronal acetylcholine receptor protein, alpha-7 chain

Mineralocorticoid receptor

Alcohol dehydrogenase 1C

Alpha-2A adrenergic receptor

Sodium-dependent dopamine transporter

Leukotriene A-4 hydrolase

Amine oxidase [flavin-containing] A

Chymotrypsinogen B

🏥 Linked Health Topics

30 · diseases via target pathways

Breast cancer

disease

Cardiovascular disease, unspecified

disease

Chronic inflammatory diseases

Carpal Tunnel Syndrome

Myocardial Infarction

syndrome

Peutz-Jeghers Syndrome

syndrome

Malignant Mesothelioma

Rheumatoid arthritis, unspecified

Inflammatory diseases

disease

Bladder cancer

disease

Abdominal aortic aneurysm

disease

Adenomatous polyposis

disease

Carcinoma in situ, unspecified

disease

Dysmenorrhea, unspecified

disease

Genitourinary tumors

disease

Gestational hypertension

disease

Oropharyngeal squamous cell carcinoma

disease

📚 PubMed References

6 · cited research

PMID 24107941 Plant sterols the better cholesterol in Alzheimer's disease? A mechanistical stu

J Neurosci

PMID 24107776 Phytosterols promote liver injury and Kupffer cell activation in parenteral nutr

Sci Transl Med

PMID 31759199 Stigmasterol stimulates transintestinal cholesterol excretion independent of liv

J Nutr Biochem

PMID 33041661 Stigmasterol sensitizes endometrial cancer cells to chemotherapy by repressing N

Cancer Cell Int

PMID 33285471 The potential LXRβ agonist stigmasterol protects against hypoxia/reoxygenation i

Phytomedicine

PMID 33708631 Stigmasterol Simultaneously Induces Apoptosis and Protective Autophagy by Inhibi

Front Oncol

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables