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Disease
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Evidence
23,295
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
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⚗️ Ingredient

Sulforathane

Open on HERB 2.0 ↗
27
Clinical Trials
8
Meta-Analyses
52
PubMed References
Top Conditions Studied with Sulforathane
Autism Spectrum Disorder 3 Prostate Cancer 2 Clinical High Risk Syndrome of Psychosis 1 Adverse Drug Interactions 1 Schizophrenia 1 Chronic Kidney Disease Stage 3|Chronic Kidney Disease Stage 1 Adenocarcinoma of the Prostate|Recurrent Prostate Cancer 1 Chronic Kidney Disease 1 Osteoarthritis 1 Breast Cancer|Dermatitis 1 Non-Alcoholic Fatty Liver Disease|Obesity|Metabolic Syndrome 1 Autism|Autistic Disorder|Autism Spectrum Disorder|Autistic B 1
📋 Sample Trials
NCT00621309
Sulforaphane as an Antagonist to Human PXR-mediated Drug-drug Interactions
Completed · Phase 1
NCT01228084
Sulforaphane in Treating Patients With Recurrent Prostate Cancer
Completed · Phase 2
NCT01335971
Broccoli Sprout Extracts Trial to See if NRF2 is Enhanced by Sulforaphane Treatment in Patients With COPD
Completed · Phase 2
📊 Sample Meta-Analyses
CRD42018108120
Role of Sulforaphane in in vivo model of Alzheimer's disease: Systematic Review and Meta-Analysis
CRD42022322665
Efficacy and safety of sulforaphane for symptoms reduction in people with autism spectrum disorder: a systematic review
Autism Spectrum Disorder (ASD) is characterized by a persistent deficit in commu
CRD42022323788
Efficacy and Tolerability of Sulforaphane in the Management of Cancers: A Systematic Review
Cancer All types of cancers in humans will be evaluated to examine the efficacy
📚 Sample References
PMID 31706979
Protective effects of sulforaphane on type 2 diabetes-induced cardiomyopathy via AMPK-mediated activation of lipid metabolic pathways and NRF2 function
Metabolism · 2020
PMID 32033211
Protective Effects of Sulforaphane on Exercise-Induced Organ Damage via Inducing Antioxidant Defense Responses
Antioxidants (Basel) · 2020
PMID 32443471
Preclinical Efficacy and Involvement of AKT, mTOR, and ERK Kinases in the Mechanism of Sulforaphane against Endometrial Cancer
Cancers (Basel) · 2020
⚗️ All Ingredient data fields for Sulforathane
⚗️ Identity
Name
Sulforathane
Aliases / Synonyms
sulforaphane; 4478-93-7; DL-Sulforaphane; 1-Isothiocyanato-4-(methylsulfinyl)butane; D,L-Sulforaphane; Sulforafan; 1-isothiocyanato-4-methylsulfinylbutane; 1-Isothiocyanato-4-(methylsulfinyl)-butane; Butane, 1-isothiocyanato-4-(methylsulfinyl)-; 4-Methylsulfinylbutyl isothiocyanate
🧪 Chemistry
Molecular Weight
177.2940
LogP
1.2479
Drug-likeness
0.359
H-Bond Acceptors
3
Rotatable Bonds
5
🔬 Structures
Canonical SMILES
CS(=O)CCCCN=C=S
Isomeric SMILES
CS(=O)CCCCN=C=S
InChIKey
SUVMJBTUFCVSAD-UHFFFAOYSA-N
InChI
InChI=1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3
🔗 External References
HERB DB
HBIN045135 ↗
PubChem CID
5350 ↗
NPASS
NPC292366
HIT
C0421
TCMID
20462
TCM-ID
23980
🔍 Raw view — every non-empty column on this row (30 fields)
name
Sulforathane
common names
sulforaphane; 4478-93-7; DL-Sulforaphane; 1-Isothiocyanato-4-(methylsulfinyl)butane; D,L-Sulforaphane; Sulforafan; 1-isothiocyanato-4-methylsulfinylbutane; 1-Isothiocyanato-4-(methylsulfinyl)-butane; Butane, 1-isothiocyanato-4-(methylsulfinyl)-; 4-Methylsulfinylbutyl isothiocyanate
herb ingredient id
HBIN045135
canonical smiles
CS(=O)CCCCN=C=S
isomeric smiles
CS(=O)CCCCN=C=S
inchi
InChI=1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3
inchikey
SUVMJBTUFCVSAD-UHFFFAOYSA-N
mol wt
177.2940
num h acceptors
3
num h donors
0
mol logp
1.2479
num rotatable bonds
5
drug likeness
0.359
tcmid ingredient id
20462
tcm id ingredient id
23980
pubchem cid
5350
npass id
NPC292366
hit id
C0421

🏥 Linked Health Topics

4 · studied for these conditions (text bridge)
Asthma
syndrome
Depressive Disorder
disease
Schizophrenia
disease
Major Depressive Disorder
disease

📋 Clinical Trials

12 · subject of clinical study
NCT00621309 Sulforaphane as an Antagonist to Human PXR-mediated Drug-drug Interactions
→ Adverse Drug Interactions
NCT01228084 Sulforaphane in Treating Patients With Recurrent Prostate Cancer
→ Adenocarcinoma of the Prostate|Recurrent Prostate
NCT01335971 Broccoli Sprout Extracts Trial to See if NRF2 is Enhanced by Sulforaphane Treatm
→ COPD
NCT01568996 Pilot Study Evaluating Sulforaphane in Atypical Nevi-Precursor Lesions
→ Atypical Nevi|Melanoma
NCT01845493 Sulforaphane Supplementation in Atopic Asthmatics
→ Asthma
NCT02561481 Sulforaphane Treatment of Children With Autism Spectrum Disorder (ASD)
→ Autism Spectrum Disorder
NCT02654743 Open Label of Clinical Trial of Sulforaphane in Children With Autism
→ Autism
NCT02677051 Sulforaphane in a New Jersey (NJ) Population of Individuals With Autism
→ Autism|Autistic Disorder|Autism Spectrum Disorder|
NCT02810964 Sulforaphane to Reduce Symptoms of Schizophrenia
→ Schizophrenia|Schizoaffective Disorder
NCT02879110 A 12-weeks Study to Evaluate Sulforaphane in Treatment of Autism Spectrum Disord
→ Autism Spectrum Disorder
NCT02880462 A 6-month Study to Evaluate Sulforaphane add-on Effects in Treatment of Schizoph
→ Schizophrenia
NCT02909959 Sulforaphane for the Treatment of Young Men With Autism Spectrum Disorder
→ Autism Spectrum Disorder|Autistic Disorder|Neurode

📊 Meta-Analyses

8 · systematic review
CRD42018108120 Role of Sulforaphane in in vivo model of Alzheimer's disease: Systematic Rev
CRD42022322665 Efficacy and safety of sulforaphane for symptoms reduction in people with autism
→ Autism Spectrum Disorder (ASD) is characterized by
CRD42022323788 Efficacy and Tolerability of Sulforaphane in the Management of Cancers: A System
→ Cancer All types of cancers in humans will be eval
CRD42022348638 Meta analysis on intervention effects of sulforaphane treatment for autism spect
→ Autism spectrum disorder
CRD42022364229 Effects of sulforaphane on renal function in animal models with kidney disease:
CRD42023440510 Dietary supplementations to mitigate the cardiopulmonary effects of air pollutio
→ Air pollution is a complex environmental issue tha
CRD42023408370 Efficacy and Safety of Sulforaphane treatment in Autism Spectrum Disorders: A me
→ Autism is a neurodevelopmental disorder affecting
CRD42023417867 Efficacy of Sulforaphane in skin cancer animal models – a systematic review

📚 PubMed References

12 · cited research
PMID 31706979 Protective effects of sulforaphane on type 2 diabetes-induced cardiomyopathy via
Metabolism
PMID 32033211 Protective Effects of Sulforaphane on Exercise-Induced Organ Damage via Inducing
Antioxidants (Basel)
PMID 32443471 Preclinical Efficacy and Involvement of AKT, mTOR, and ERK Kinases in the Mechan
Cancers (Basel)
PMID 32472077 Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocr
Oncogene
PMID 32641994 Sulforaphane elicts dual therapeutic effects on Renal Inflammatory Injury and cr
Theranostics
PMID 32659677 Sulforaphane controls the release of paracrine factors by keratinocytes and thus
Phytomedicine
PMID 32710977 Sulforaphane alleviates ethanol-mediated central inhibition and reverses chronic
Neuropharmacology
PMID 32859007 Sulforaphane Inhibits MGO-AGE-Mediated Neuroinflammation by Suppressing NF-κB, M
Antioxidants (Basel)
PMID 32940670 Sulforaphane prevents type 2 diabetes-induced nephropathy via AMPK-mediated acti
Clin Sci (Lond)
PMID 33023225 Discovery of Sulforaphane as a Potent BACE1 Inhibitor Based on Kinetics and Comp
Nutrients
PMID 33067900 Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nr
Aging Cell
PMID 33079284 Sulforaphane Induces Glioprotection After LPS Challenge
Cell Mol Neurobiol
How relationships are computed
  • Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
  • Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
  • Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
  • Ingredient ↔ Target: empty — needs HERB_ingredient_target import
  • Target ↔ Disease: empty — needs HERB_target_disease import
  • Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables