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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Tauroursodeoxycholic acid

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Tauroursodeoxycholic acid

Amyotrophic Lateral Sclerosis 2 Amyloidosis; Heart (Manifestation)|Senile Cardiac Amyloidosi 1 Type 2 Diabetes Mellitus 1 TTR Cardiac Amyloidosis 1 Transthyretin Amyloidosis 1 Progressive Multiple Sclerosis 1 Primary Biliary Cirrhosis 1 HIV Related Insulin Resistance|Protease Inhibitor Related In 1 Cystic Fibrosis 1 Cholestasis 1

📋 Sample Trials

NCT00004410

Randomized Study of Tauroursodeoxycholic Acid in Prophylactic Therapy of Total Parenteral Nutrition Associated Cholestasis in Infants

Completed

NCT00004441

Study of Tauroursodeoxycholic Acid for Hepatobiliary Disease in Cystic Fibrosis

Completed

NCT00877604

Efficacy and Tolerability of Tauroursodeoxycholic Acid in Amyotrophic Lateral Sclerosis

Completed · Phase 2

📊 Sample Meta-Analyses

None linked yet.

📚 Sample References

PMID 30785084

TUDCA-treated chronic kidney disease-derived hMSCs improve therapeutic efficacy in ischemic disease via PrPC

Redox Biol · 2019

PMID 28688954

Rifampicin-induced injury in HepG2 cells is alleviated by TUDCA via increasing bile acid transporters expression and enhancing the Nrf2-mediated adaptive response

Free Radic Biol Med · 2017

PMID 25695629

Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis

Nat Commun · 2015

⚗️ All Ingredient data fields for Tauroursodeoxycholic acid

⚗️ Identity

Name

Tauroursodeoxycholic acid

Aliases / Synonyms

14605-22-2; Tauroursodeoxycholate; TUDCA; Ursodeoxycholyltaurine; Taurursodiol; ursodoxicoltaurine; Taurolite; Taurursodiol [USAN]; UR 906

🧪 Chemistry

Molecular Weight

499.7140

LogP

3.3973

Drug-likeness

0.398

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC(CCC(=O)NCCS(=O)(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C

Isomeric SMILES

C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C

InChIKey

BHTRKEVKTKCXOH-LBSADWJPSA-N

InChI

InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20+,21+,22+,24+,25+,26-/m1/s1

🔗 External References

HERB DB

HBIN045592 ↗

PubChem CID

9848818 ↗

NPASS

NPC233575

TCMID

23140; 20719

🔍 Raw view — every non-empty column on this row (28 fields)

name

Tauroursodeoxycholic acid

common names

14605-22-2; Tauroursodeoxycholate; TUDCA; Ursodeoxycholyltaurine; Taurursodiol; ursodoxicoltaurine; Taurolite; Taurursodiol [USAN]; UR 906

herb ingredient id

HBIN045592

canonical smiles

CC(CCC(=O)NCCS(=O)(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C

isomeric smiles

C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C

inchi

inchikey

BHTRKEVKTKCXOH-LBSADWJPSA-N

mol wt

499.7140

num h acceptors

num h donors

mol logp

3.3973

num rotatable bonds

drug likeness

0.398

tcmid ingredient id

23140; 20719

pubchem cid

9848818

npass id

NPC233575

🏥 Linked Health Topics

5 · studied for these conditions (text bridge)

Amyotrophic Lateral Sclerosis

syndrome

Primary Biliary Cirrhosis

Progressive Multiple Sclerosis

syndrome

📋 Clinical Trials

11 · subject of clinical study

NCT00004410 Randomized Study of Tauroursodeoxycholic Acid in Prophylactic Therapy of Total P

→ Cholestasis

NCT00004441 Study of Tauroursodeoxycholic Acid for Hepatobiliary Disease in Cystic Fibrosis

→ Cystic Fibrosis

NCT00877604 Efficacy and Tolerability of Tauroursodeoxycholic Acid in Amyotrophic Lateral Sc

→ Amyotrophic Lateral Sclerosis

NCT01171859 Safety, Efficacy and Pharmacokinetics of Doxycycline Plus Tauroursodeoxycholic A

→ Transthyretin Amyloidosis

NCT01857284 Safety and Efficacy of Tauroursodeoxycholic Acid Versus Ursofalk in the Treatmen

→ Primary Biliary Cirrhosis

NCT01877551 Tauroursodeoxycholic Acid for Protease-inhibitor Associated Insulin Resistance

→ HIV Related Insulin Resistance|Protease Inhibitor

NCT03331432 Effects of Dietary Supplement Tauroursodeoxycholic Acid on Vascular Function

→ Type 2 Diabetes Mellitus

NCT03481972 A Study of Doxycycline and Tauroursodeoxycholic Acid (Doxy/TUDCA) Plus Standard

→ TTR Cardiac Amyloidosis

NCT01855360 Doxycycline and TUDCA in Patients With Transthyretin Amyloid Cardiomyopathy

→ Amyloidosis; Heart (Manifestation)|Senile Cardiac

NCT03423121 A Trial of Bile Acid Supplementation in Patients With Multiple Sclerosis

→ Progressive Multiple Sclerosis

NCT05753852 Open Label Extension of TUDCA-ALS Study

→ Amyotrophic Lateral Sclerosis

📚 PubMed References

12 · cited research

PMID 30785084 TUDCA-treated chronic kidney disease-derived hMSCs improve therapeutic efficacy

Redox Biol

PMID 28688954 Rifampicin-induced injury in HepG2 cells is alleviated by TUDCA via increasing b

Free Radic Biol Med

PMID 25695629 Integration of Hippo signalling and the unfolded protein response to restrain li

Nat Commun

PMID 25407160 Tauroursodeoxycholic acid, a bile acid, promotes blood vessel repair by recruiti

Stem Cells

PMID 24645669 Tauroursodeoxycholic acid reduces glial cell activation in an animal model of ac

J Neuroinflammation

PMID 24225943 Restoration of the unfolded protein response in pancreatic β cells protects mice

Sci Transl Med

PMID 23707365 ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum str

J Hepatol

PMID 22994543 Tauroursodeoxycholic acid affects PPARγ and TLR4 in Steatotic liver transplantat

Am J Transplant

PMID 22974733 Tauroursodeoxycholic acid (TUDCA) supplementation prevents cognitive impairment

Neurobiol Dis

PMID 22081301 Chronic inhibition of endoplasmic reticulum stress and inflammation prevents isc

J Pathol

PMID 33261652 Tauroursodeoxycholic acid attenuates neuronal apoptosis via the TGR5/ SIRT3 path

Biol Res

PMID 33681203 Treatment of in vitro-Matured Bovine Oocytes With Tauroursodeoxycholic Acid Modu

Front Cell Dev Biol

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables