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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Taxifolin

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Taxifolin

Antioxidative Stress|Cold|Influenza|Aging|Inflammation 1

📋 Sample Trials

NCT05190432

Taxifolin/Ergothioneine and Immune Biomarkers in Healthy Volunteers (TaxEr)

Active_Not_Recruiting

📊 Sample Meta-Analyses

None linked yet.

📚 Sample References

PMID 31036637

Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy

Proc Natl Acad Sci U S A · 2019

PMID 32120244

Dihydroquercetin protects against renal fibrosis by activating the Nrf2 pathway

Phytomedicine · 2020

PMID 32508636

Dihydroquercetin Activates AMPK/Nrf2/HO-1 Signaling in Macrophages and Attenuates Inflammation in LPS-Induced Endotoxemic Mice

Front Pharmacol · 2020

⚗️ All Ingredient data fields for Taxifolin

⚗️ Identity

Name

Taxifolin

Aliases / Synonyms

480-18-2; (+)-Taxifolin; dihydroquercetin; Distylin; Taxifoliol; 24198-97-8; (2R,3R)-Dihydroquercetin; (+)-Dihydroquercetin; Lavitol

🧪 Chemistry

Molecular Weight

304.2540

LogP

1.1863

Drug-likeness

0.501

Oral Bioavailability

57.8420

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C1=CC(=C(C=C1C2C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O

Isomeric SMILES

C1=CC(=C(C=C1[C@@H]2[C@H](C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O

InChIKey

CXQWRCVTCMQVQX-LSDHHAIUSA-N

InChI

InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1

🔗 External References

HERB DB

HBIN045672 ↗

PubChem CID

439533 ↗

CAS Number

480-18-2 ↗

NPASS

NPC246162

HIT

C0587

SymMap

564

TCMID

23050

TCMSP

MOL004576

TCM-ID

615

🔍 Raw view — every non-empty column on this row (36 fields)

name

Taxifolin

common names

480-18-2; (+)-Taxifolin; dihydroquercetin; Distylin; Taxifoliol; 24198-97-8; (2R,3R)-Dihydroquercetin; (+)-Dihydroquercetin; Lavitol

herb ingredient id

HBIN045672

canonical smiles

C1=CC(=C(C=C1C2C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O

isomeric smiles

C1=CC(=C(C=C1[C@@H]2[C@H](C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O

inchi

InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1

inchikey

CXQWRCVTCMQVQX-LSDHHAIUSA-N

mol wt

304.2540

num h acceptors

num h donors

mol logp

1.1863

num rotatable bonds

drug likeness

0.501

ob score

57.8420

cas id

480-18-2

symmap mol id

564

tcmid ingredient id

23050

tcmsp ingredient id

MOL004576

tcm id ingredient id

615

pubchem cid

439533

npass id

NPC246162

hit id

C0587

tcmsp mol id

MOL004576

tcmsp molecule id

4576

🌿 Related Herbs

1 · contains this compound

Ephedra

Ma Huang

🧬 Gene / Protein Targets

12 · directly binds these targets

ICAM1

Gene ICAM1

DGAT2

Gene DGAT2

Prostaglandin G/H synthase 1

Prostaglandin G/H synthase 2

Heat shock protein HSP 90

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform

Transcription factor p65

Aldose reductase

Retinoic acid receptor RXR-alpha

Microsomal triglyceride transfer protein large subunit

Apolipoprotein B-100

Metal-binding activator 1

🏥 Linked Health Topics

30 · diseases via target pathways

Cardiovascular disease, unspecified

disease

Chronic inflammatory diseases

Carpal Tunnel Syndrome

Myocardial Infarction

syndrome

Peutz-Jeghers Syndrome

syndrome

Malignant Mesothelioma

Rheumatoid arthritis, unspecified

Inflammatory diseases

disease

Bladder cancer

disease

Abdominal aortic aneurysm

disease

Adenomatous polyposis

disease

Carcinoma in situ, unspecified

disease

Dysmenorrhea, unspecified

disease

Genitourinary tumors

disease

Gestational hypertension

disease

Oropharyngeal squamous cell carcinoma

disease

📋 Clinical Trials

1 · subject of clinical study

NCT05190432 Taxifolin/Ergothioneine and Immune Biomarkers in Healthy Volunteers (TaxEr)

→ Antioxidative Stress|Cold|Influenza|Aging|Inflamma

📚 PubMed References

12 · cited research

PMID 31036637 Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy

Proc Natl Acad Sci U S A

PMID 32120244 Dihydroquercetin protects against renal fibrosis by activating the Nrf2 pathway

Phytomedicine

PMID 32508636 Dihydroquercetin Activates AMPK/Nrf2/HO-1 Signaling in Macrophages and Attenuate

Front Pharmacol

PMID 32828744 Taxifolin ameliorates iron overload-induced hepatocellular injury: Modulating PI

Chem Biol Interact

PMID 33157091 Taxifolin improves disorders of glucose metabolism and water-salt metabolism in

Life Sci

PMID 33325949 Taxifolin ameliorate high-fat-diet feeding plus acute ethanol binge-induced stea

Food Funct

PMID 33664740 Dietary Taxifolin Protects Against Dextran Sulfate Sodium-Induced Colitis via NF

Front Immunol

PMID 34572963 Taxifolin and Sorghum Ethanol Extract Protect against Hepatic Insulin Resistance

Antioxidants (Basel)

PMID 34673859 Dihydroquercetin supplement alleviates colonic inflammation potentially through

Food Funct

PMID 34942457 Dihydroquercetin suppresses cigarette smoke induced ferroptosis in the pathogene

Phytomedicine

PMID 35000533 Taxifolin improves inflammatory injury of human bronchial epithelial cells by in

Bioengineered

PMID 35268045 Taxifolin Alleviates DSS-Induced Ulcerative Colitis by Acting on Gut Microbiome

Nutrients

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables