Relationship Graph Explorer
Follow the connections
Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.
🌿
Herb
6,826
→
⚗️
Ingredient
44,598
→
🧬
Gene Target
15,695
→
🏥
Disease
30,467
→
🧪
Evidence
23,295
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
🧬 Gene Target
TNF
1
Clinical Trials
0
Meta-Analyses
1,139
PubMed References
📋 Sample Trials
NCT04772508
Effect of Amnion Membrane With and Without Taurine on GCF TNF α Level.
Completed
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 28817116
Total tanshinones exhibits anti-inflammatory effects through blocking TLR4 dimerization via the MyD88 pathway
Cell Death Dis · 2017
PMID 30794925
Dihydrotanshinone exhibits an anti-inflammatory effect in vitro and in vivo through blocking TLR4 dimerization
Pharmacol Res · 2019
PMID 31348992
Computational systems pharmacology reveals an antiplatelet and neuroprotective mechanism of Deng-Zhan-Xi-Xin injection in the treatment of ischemic stroke
Pharmacol Res · 2019
🧬 All Gene Target data fields for TNF
🧬 Identity
Gene Symbol
TNF
Gene Aliases
DIF; TNF-alpha; TNFA; TNFSF2; TNLG1F
Protein Name
tumor necrosis factor
Gene Type
protein-coding
TTD Target Type
Successful target
📍 Location
Organism
Homo sapiens
Taxonomy ID
9606
Chromosome
6
Map Location
6p21.33
🔗 External References
🔍 Raw view — every non-empty column on this row (28 fields)
name
TNF
gene symbol
TNF
gene alias name
DIF; TNF-alpha; TNFA; TNFSF2; TNLG1F
protein name
tumor necrosis factor
type of gene
protein-coding
ttd target type
Successful target
organism
Homo sapiens
taxonomy id
9606
map location
6p21.33
chromosome
6
entrez id
7124
omim id
191160
hgnc id
11892
ensembl id
ENSG00000232810
ttd id
T20178
target id str
HBTAR004140
tcmsp target id
265
🌿 Related Herbs
1 · contains this compound⚗️ Related Ingredients
3 · compounds in this herb🏥 Linked Health Topics
12 · diseases via target pathwaysAsthma
syndrome
Heart Failure
syndrome
Congestive Heart Failure
syndrome
Hyperimmunoglobulinemia D
syndrome
Periodic Fever Syndrome
syndrome
Solid Tumor
disease
Noninsulin-dependent diabetes mellitus
disease
Rheumatic diseases
disease
Rheumatoid arthritis, unspecified
disease
Crohns's Disease, unspecified
disease
Chronic inflammatory diseases
disease
Behcet's disease
disease
📋 Clinical Trials
1 · subject of clinical studyNCT04772508 Effect of Amnion Membrane With and Without Taurine on GCF TNF α Level.
→ Periodontitis
📚 PubMed References
12 · cited researchPMID 28817116 Total tanshinones exhibits anti-inflammatory effects through blocking TLR4 dimer
Cell Death Dis
PMID 30794925 Dihydrotanshinone exhibits an anti-inflammatory effect in vitro and in vivo thro
Pharmacol Res
PMID 31348992 Computational systems pharmacology reveals an antiplatelet and neuroprotective m
Pharmacol Res
PMID 31569788 Anti-Inflammatory Mechanisms of Koreanaside A, a Lignan Isolated from the Flower
Cells
PMID 30167641 Analysis of the Effect of Gentian Violet on Apoptosis and Proliferation in Cutan
JAMA Dermatol
PMID 24930437 Keratins 8 and 18 are type II acute-phase responsive genes overexpressed in huma
Liver Int
PMID 28300618 The novel and potent anti-depressive action of triptolide and its influences on
Brain Behav Immun
PMID 24145604 Resveratrol attenuates vascular endothelial inflammation by inducing autophagy t
Autophagy
PMID 21699681 Resveratrol retards progression of diabetic nephropathy through modulations of o
J Biomed Sci
PMID 23557933 One-year supplementation with a grape extract containing resveratrol modulates i
Pharmacol Res
PMID 25281414 Rutin has intestinal antiinflammatory effects in the CD4+ CD62L+ T cell transfer
Pharmacol Res
PMID 28448946 Oral administration of methysticin improves cognitive deficits in a mouse model
Redox Biol
How relationships are computed
- Clinical Trials / Meta-Analyses / References: direct foreign-key link via
subject_entity_id(Phase 2d wireup) - Formula ↔ Herbs: text bridge via
formulas.herbs_in_pinyinmatchingherbs.pinyin_name - Herb ↔ Ingredient:
ACTIVE — direct link via
herb_ingredients - Ingredient ↔ Target:
ACTIVE — direct link via
ingredient_targets - Target ↔ Disease:
ACTIVE — direct link via
target_health_topics - Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables