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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

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Herb
6,826
→
⚗️
Ingredient
44,595
→
🧬
Gene Target
15,505
→
🏥
Disease
30,170
→
🧪
Evidence
23,295
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases
Quick picks: Abetalipoproteinemia Abortion, Habitual Agenesis Acanthamoeba Keratitis Acanthosis Nigricans Achondrogenesis Achondroplasia Acne Vulgaris Acne Keloid Apert Syndrome
🏥 Disease / Health Topic

Hyperpigmentation

Open on HERB 2.0 ↗
5
Clinical Trials
3
Meta-Analyses
0
PubMed References
📋 Sample Trials
NCT03719274
Vitamin C Depigmenattion Versus Conventional Technique
Completed
NCT01542138
Clinical Trial of 4% Niacinamide Versus 0.05% Desonide for the Treatment of Axillar Hyperpigmentation
Completed · Phase 4
NCT01038869
Efficacy and Safety Study of Finacea to Treat Acne Vulgaris and Post-Inflammatory Hyperpigmentation (PIH)
Completed · Phase 4
📊 Sample Meta-Analyses
CRD42020220648
The effectiveness of topical azelaic acid for dermatological conditions and cosmetic skin care
Skin conditions: anti-ageing and the dermatological conditions of rosacea, melas
CRD42023422653
Application of Vitamin C in Melasma:A Meta-Analysis and Systematic Review
Melasma is a chronic, acquired facial hyperpigmentation skin disease that is ver
CRD42023454133
A Meta-analysis-Based Assessment of Microneedling combined with Vitamin C in Melasma
Melasma is a chronic, acquired facial hyperpigmentation skin disease that is ver
📚 Sample References
None linked yet.
🏥 All Disease / Health Topic data fields for Hyperpigmentation
🏥 Names
Disease Name
Hyperpigmentation
Alias Names
Skin Hyperpigmentation; Hyperpigmentation; Patchy Darkened Skin; Melanoderma; Increased Skin Pigmentation; Melanodermia; Cutaneous Hyperpigmentation; Hyperpigmentation of The Skin
Topic Type
phenotype
🧬 Ontology Classifications
DisGeNET Type
phenotype
UMLS Type
Pathologic Function
MeSH Class
Skin and Connective Tissue Diseases
HPO Class
Abnormality of the integument
🔗 External References
HERB DB
HBDIS004164 ↗
MeSH
D017495 ↗
HPO
HP:0000953 ↗
DisGeNET
C0162834
🔍 Raw view — every non-empty column on this row (26 fields)
name
Hyperpigmentation
alias name
Skin Hyperpigmentation; Hyperpigmentation; Patchy Darkened Skin; Melanoderma; Increased Skin Pigmentation; Melanodermia; Cutaneous Hyperpigmentation; Hyperpigmentation of The Skin
topic type
phenotype
disgenet disease type
phenotype
umls disease type
Pathologic Function
mesh disease class
Skin and Connective Tissue Diseases
hpo disease class
Abnormality of the integument
umls disease type id
T046
mesh disease class id
C17
hpo disease class id
HP:0001574
herb disease id
HBDIS004164
disgenet id
C0162834
mesh id
D017495
hpo id
HP:0000953

⚗️ Related Ingredients

5 · shared evidence
Azelaic acid
Hydroquinone
L-ascorbic acid
Nca
Neh

📋 Clinical Trials

5 · subject of clinical study
NCT03719274 Vitamin C Depigmenattion Versus Conventional Technique
→ Melanin Hyperpigmentation
NCT01542138 Clinical Trial of 4% Niacinamide Versus 0.05% Desonide for the Treatment of Axil
→ Hyperpigmentation
NCT01038869 Efficacy and Safety Study of Finacea to Treat Acne Vulgaris and Post-Inflammator
→ Acne Vulgaris|Post Inflammatory Hyperpigmentation
NCT05511948 Randomized and Open Label Study for Safety and Efficacy of DBI-102 vs. Vehicle v
→ Hyperpigmentation
NCT05206318 Efficacy and Safety of Topical Cysteamine for Postinflammatory Hyperpigmentation
→ Hyperpigmentation; Postinflammatory

📊 Meta-Analyses

3 · systematic review
CRD42020220648 The effectiveness of topical azelaic acid for dermatological conditions and cosm
→ Skin conditions: anti-ageing and the dermatologica
CRD42023422653 Application of Vitamin C in Melasma:A Meta-Analysis and Systematic Review
→ Melasma is a chronic, acquired facial hyperpigment
CRD42023454133 A Meta-analysis-Based Assessment of Microneedling combined with Vitamin C in Mel
→ Melasma is a chronic, acquired facial hyperpigment
How relationships are computed
  • Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
  • Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
  • Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
  • Ingredient ↔ Target: empty — needs HERB_ingredient_target import
  • Target ↔ Disease: empty — needs HERB_target_disease import
  • Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables