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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Testosterone

Open on HERB 2.0 ↗

233

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Testosterone

Hypogonadism 35 Hypoactive Sexual Desire Disorder 12 Male Hypogonadism 6 Contraception 6 Prostate Cancer 5 Healthy 5 Secondary Hypogonadism 5 Hypogonadism, Male 3 Spinal Cord Injury 3 Adult Male Hypogonadism 3 Depression 2 Female Sexual Dysfunction 2

📋 Sample Trials

NCT00001079

A Study of Megestrol Acetate Alone or in Combination With Testosterone Enanthate Drug in the Treatment of HIV-Associated Weight Loss

Completed · Phase 2

NCT00004400

Phase II Randomized Study of Physiologic Testosterone Replacement in Premenopausal, HIV-Positive Women

Completed · Phase 2

NCT00004771

Phase II Study of Leuprolide and Testosterone for Men With Kennedy's Disease or Other Motor Neuron Disease

Completed · Phase 2

📊 Sample Meta-Analyses

CRD42021281981

A systematic review of the association between testosterone and female sexual response.

Outcome: Female sexual response, assessed by any measure assessing a sexual resp

CRD42018109738

The effects of testosterone on bone health in aging males with testosterone deficiency: a systematic review and meta-analysis

In addition to sexual dysfunction, depressed mood, and fatigue, testosterone def

CRD42017065598

Systematic review of testosterone replacement in obese men with low testosterone levels

Obesity is a complex condition that affects all ages and different socioeconomic

📚 Sample References

None linked yet.

⚗️ All Ingredient data fields for Testosterone

⚗️ Identity

Name

Testosterone

Aliases / Synonyms

58-22-0; Testosteron; Androderm; Testim; Homosterone; Virosterone; Testiculosterone; Androlin; Mertestate

🧪 Chemistry

Molecular Weight

288.4310

LogP

3.8792

Drug-likeness

0.734

H-Bond Acceptors

H-Bond Donors

🔬 Structures

Canonical SMILES

CC12CCC3C(C1CCC2O)CCC4=CC(=O)CCC34C

Isomeric SMILES

C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=CC(=O)CC[C@]34C

InChIKey

MUMGGOZAMZWBJJ-DYKIIFRCSA-N

InChI

InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1

🔗 External References

HERB DB

HBIN046010 ↗

PubChem CID

6013 ↗

DrugBank

DB00624 ↗

NPASS

NPC161423

HIT

C0436

SymMap

17880

TCMID

21006

🔍 Raw view — every non-empty column on this row (31 fields)

name

Testosterone

common names

58-22-0; Testosteron; Androderm; Testim; Homosterone; Virosterone; Testiculosterone; Androlin; Mertestate

herb ingredient id

HBIN046010

canonical smiles

CC12CCC3C(C1CCC2O)CCC4=CC(=O)CCC34C

isomeric smiles

C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=CC(=O)CC[C@]34C

inchi

InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1

inchikey

MUMGGOZAMZWBJJ-DYKIIFRCSA-N

mol wt

288.4310

num h acceptors

num h donors

mol logp

3.8792

num rotatable bonds

drug likeness

0.734

symmap mol id

17880

tcmid ingredient id

21006

pubchem cid

6013

drugbank id

DB00624

npass id

NPC161423

hit id

C0436

🏥 Linked Health Topics

12 · studied for these conditions (text bridge)

Coronary Heart Disease

Hypoactive Sexual Desire Disorder

Testicular Hypogonadism

syndrome

📋 Clinical Trials

12 · subject of clinical study

NCT00001079 A Study of Megestrol Acetate Alone or in Combination With Testosterone Enanthate

→ HIV Infections|HIV Wasting Syndrome

NCT00004400 Phase II Randomized Study of Physiologic Testosterone Replacement in Premenopaus

→ HIV Infections|Cachexia

NCT00004771 Phase II Study of Leuprolide and Testosterone for Men With Kennedy's Disease or

→ Spinal Muscular Atrophy|Amyotrophic Lateral Sclero

NCT00006044 Testosterone in Treating Patients With Progressive Prostate Cancer That No Longe

→ Prostate Cancer

NCT00006158 AIDS Wasting in Women: Anabolic Effects of Testosterone

→ AIDS Wasting Syndrome

NCT00009555 Testosterone for HIV-Positive Men With Reduced Serum Testosterone Levels and Abd

→ HIV Infections

NCT00018356 Physiologic Effects of PRMS & Testosterone in the Debilitated Elderly

→ Muscle Weakness|Muscular Atrophy

NCT00037999 The Effect of Testosterone Supplementation on Rehabilitation Outcomes

→ Aging|Frail Elderly|Rehabilitation

NCT00075855 Low-Dose Testosterone in Improving Libido in Postmenopausal Female Cancer Surviv

→ Cancer Survivor|Sexual Dysfunction|Sexuality and R

NCT00080483 Testosterone and Growth Hormone for Bone Loss in Men

→ Hypopituitarism|Hypogonadism|Growth Hormone Defici

NCT00080756 Deslorelin Combined With Low-Dose Add-Back Estradiol and Testosterone in Prevent

→ brca1 Mutation Carrier|brca2 Mutation Carrier|Brea

NCT00140153 Testosterone in Female Hypoactive Sexual Desire Disorder

→ Hypoactive Sexual Desire Disorder

📊 Meta-Analyses

12 · systematic review

CRD42021281981 A systematic review of the association between testosterone and female sexual re

→ Outcome: Female sexual response, assessed by any m

CRD42018109738 The effects of testosterone on bone health in aging males with testosterone defi

→ In addition to sexual dysfunction, depressed mood,

CRD42017065598 Systematic review of testosterone replacement in obese men with low testosterone

→ Obesity is a complex condition that affects all ag

CRD42022353457 Does any testosterone "booster" really increase serum total testosterone

CRD42018109991 Efficacy and safety of testosterone supplementary therapy in the treatment of th

→ Insulin resistance is a target organ of insulin ac

CRD42014009226 Testosterone and its derivatives for the treatment of sarcopenia in elderly male

→ In 2010 the European Working group on Sarcopenia i

CRD42021288477 Protective role of testosterone against temporomandibular joint pain: An interpr

CRD42011001815 Testosterone therapy and cardiovasclar events among men: a systematic review and

CRD42013005017 Testosterone therapy and obesity among men and women: a systematic review and me

→ Obesity.

CRD42013005097 Testosterone therapy and traditional cardiovascular disease risk factors among m

→ Changes in traditional cardiovascular disease fact

CRD42014009963 Efficacy and safety of testosterone replacement therapy in adult men: a systemat

→ Testosterone is indicated as a replacement therapy

CRD42015015839 The effect of testosterone replacement therapy on erythropoiesis in middle aged

→ Testosterone deficiency in men has become a common

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables