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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.
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Ingredient
44,598
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Gene Target
15,695
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Disease
30,467
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Evidence
23,295
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
⚗️ Ingredient
Theanine
9
Clinical Trials
5
Meta-Analyses
13
PubMed References
Top Conditions Studied with Theanine
Attention Deficit Hyperactivity Disorder 2
Stress 2
Cognitive Function|Mood 1
The health-promoting properties of green tea are well establ 1
Sleep quality 1
Our systematic review will focus on human cognitive function 1
Neuropsychiatric disorders: Neuropsychiatric disorders are a 1
Schizophrenia 1
L-theanine 1
Healthy Students 1
Cortical Excitability|Psychiatric Disorder 1
📋 Sample Trials
NCT00981955
The Effects of Caffeine and L-theanine Both Alone and in Combination on Cerebral Blood Flow, Cognition and Mood
Completed · Phase 4
NCT02770105
Theanine and Caffeine on Neurophysiology of Attention
Completed
NCT03533556
Effects of L-theanine and Caffeine on Attention and Attention-related Brain Activity of Children With Attention Deficit Hyperactivity Disorder
Completed · Early_Phase 1
📊 Sample Meta-Analyses
CRD42022351601
The effects of tea (Camellia sinensis) or its bioactive compounds L-theanine or L-theanine plus caffeine on cognition, sleep, and mood in apparently healthy subjects: a systematic review
Our systematic review will focus on human cognitive function, sleep, and mood.
CRD42018104792
The effects of the unique green tea amino acid L-theanine on the stress response and anxiety in human clinical trials – a systematic review of randomised controlled trials
The health-promoting properties of green tea are well established and it is cons
CRD42020191960
Theanine and cancer: A systematic review of the literature
📚 Sample References
PMID 31837331
Theanine attenuates hippocampus damage of rat cerebral ischemia-reperfusion injury by inhibiting HO-1 expression and activating ERK1/2 pathway
Life Sci · 2020
PMID 32057039
l-Theanine regulates glucose, lipid, and protein metabolism via insulin and AMP-activated protein kinase signaling pathways
Food Funct · 2020
PMID 32402912
l-Theanine attenuates neointimal hyperplasia via suppression of vascular smooth muscle cell phenotypic modulation
J Nutr Biochem · 2020
⚗️ All Ingredient data fields for Theanine
⚗️ Identity
Name
Theanine
Aliases / Synonyms
L-Theanine; 3081-61-6; N-Ethyl-L-glutamine; Theanin; Suntheanine; (S)-2-Amino-5-(ethylamino)-5-oxopentanoic acid; N5-Ethyl-L-glutamine; CCRIS 7326; C7H14N2O3
🧪 Chemistry
Molecular Weight
174.2000
LogP
-0.6854
Drug-likeness
0.514
H-Bond Acceptors
3
H-Bond Donors
3
Rotatable Bonds
5
🔬 Structures
Canonical SMILES
CCNC(=O)CCC(C(=O)O)N
Isomeric SMILES
CCNC(=O)CC[C@@H](C(=O)O)N
InChIKey
DATAGRPVKZEWHA-YFKPBYRVSA-N
InChI
InChI=1S/C7H14N2O3/c1-2-9-6(10)4-3-5(8)7(11)12/h5H,2-4,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
🔗 External References
🔍 Raw view — every non-empty column on this row (28 fields)
name
Theanine
common names
L-Theanine; 3081-61-6; N-Ethyl-L-glutamine; Theanin; Suntheanine; (S)-2-Amino-5-(ethylamino)-5-oxopentanoic acid; N5-Ethyl-L-glutamine; CCRIS 7326; C7H14N2O3
herb ingredient id
HBIN046248
canonical smiles
CCNC(=O)CCC(C(=O)O)N
isomeric smiles
CCNC(=O)CC[C@@H](C(=O)O)N
inchi
InChI=1S/C7H14N2O3/c1-2-9-6(10)4-3-5(8)7(11)12/h5H,2-4,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
inchikey
DATAGRPVKZEWHA-YFKPBYRVSA-N
mol wt
174.2000
num h acceptors
3
num h donors
3
mol logp
-0.6854
num rotatable bonds
5
drug likeness
0.514
tcmid ingredient id
21265
pubchem cid
439378
drugbank id
DB12444
🏥 Linked Health Topics
2 · diseases via target pathways📋 Clinical Trials
9 · subject of clinical studyNCT00981955 The Effects of Caffeine and L-theanine Both Alone and in Combination on Cerebral
→ Cognitive Function|Mood
NCT02770105 Theanine and Caffeine on Neurophysiology of Attention
→ L-theanine
NCT03533556 Effects of L-theanine and Caffeine on Attention and Attention-related Brain Acti
→ Attention Deficit Hyperactivity Disorder
NCT00291070 Effects of L-Theanine in Boys With ADHD
→ Attention Deficit Hyperactivity Disorder
NCT00372151 L-Theanine in the Management of Schizophrenia
→ Schizophrenia
NCT01361204 Anti-stress Effect of Theanine on Students During Long-term Pharmacy Practices
→ Healthy Students
NCT04749745 Effects of L-theanine on Motor Cortex Excitability in Healthy Subjects: A Paired
→ Cortical Excitability|Psychiatric Disorder
NCT05808595 The Safety and Efficacy of AlphaWave® L-Theanine on Adults Who Experience Modera
→ Stress
NCT05854017 Effects of a Theanine for Stress Relief Formulation in Individuals Who Report Oc
→ Stress
📊 Meta-Analyses
5 · systematic reviewCRD42022351601 The effects of tea (Camellia sinensis) or its bioactive compounds L-theanine or
→ Our systematic review will focus on human cognitiv
CRD42018104792 The effects of the unique green tea amino acid L-theanine on the stress response
→ The health-promoting properties of green tea are w
CRD42020191960 Theanine and cancer: A systematic review of the literature
CRD42022304635 The effects of L-Theanine consumption on sleep in humans: a systematic review
→ Sleep quality
CRD42023478563 Efficacy and Safety of L-Theanine in Neuropsychiatric Disorders: A Systematic Re
→ Neuropsychiatric disorders: Neuropsychiatric disor
📚 PubMed References
12 · cited researchPMID 31837331 Theanine attenuates hippocampus damage of rat cerebral ischemia-reperfusion inju
Life Sci
PMID 32057039 l-Theanine regulates glucose, lipid, and protein metabolism via insulin and AMP-
Food Funct
PMID 32402912 l-Theanine attenuates neointimal hyperplasia via suppression of vascular smooth
J Nutr Biochem
PMID 32635404 L-Theanine Reduced the Development of Knee Osteoarthritis in Rats via Its Anti-I
Nutrients
PMID 33249185 L-theanine suppresses the metastasis of prostate cancer by downregulating MMP9 a
J Nutr Biochem
PMID 34037653 L-Theanine regulates glutamine metabolism and immune function by binding to cann
Food Funct
PMID 34336115 l-Theanine Ameliorates d-Galactose-Induced Brain Damage in Rats via Inhibiting A
Oxid Med Cell Longev
PMID 34381369 L-Theanine Alleviates IMQ-Induced Psoriasis Like Skin Inflammation by Downregula
Front Pharmacol
PMID 34517095 Effect of dietary L-theanine supplementation on skeletal muscle fiber type trans
J Nutr Biochem
PMID 34542664 L-Theanine inhibits melanoma cell growth and migration via regulating expression
Eur J Nutr
PMID 35636523 L-theanine protects rat kidney from D-galactose-induced injury via inhibition of
Eur J Pharmacol
PMID 36116531 Adipose stem cells preincubated with theanine exert liver regeneration through i
Life Sci
How relationships are computed
- Clinical Trials / Meta-Analyses / References: direct foreign-key link via
subject_entity_id(Phase 2d wireup) - Formula ↔ Herbs: text bridge via
formulas.herbs_in_pinyinmatchingherbs.pinyin_name - Herb ↔ Ingredient:
ACTIVE — direct link via
herb_ingredients - Ingredient ↔ Target:
ACTIVE — direct link via
ingredient_targets - Target ↔ Disease:
ACTIVE — direct link via
target_health_topics - Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables