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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Theophylline

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Theophylline

Chronic Obstructive Pulmonary Disease 4 COPD 3 Healthy 2 Asthma 2 Pharmacokinetics 2 Bronchiectasis 2 Pseudohypoparathyroidism|Albright Hereditary Osteodystrophy| 1 Covid19|Anosmia|Olfactory Disorder|Covid-19 Pandemic|SARS-Co 1 Theophylline, the most commonly used methylxanthine，has been 1 Acute Kidney Injury|HIE 1 Pseudohypoparathyroidism|Albright Hereditary Osteodystrophy 1 COVID-19 1

📋 Sample Trials

NCT00983905

Drug-Drug Interaction Study of Colchicine and Theophylline

Completed · Phase 1

NCT01601132

Drug Interaction Study of Colchicine and Theophylline

Completed · Phase 4

NCT00003684

Theophylline in Treating Cancer Patients With Shortness of Breath

Completed · Phase 3

📊 Sample Meta-Analyses

CRD42022304383

The diuretic effect of aminophylline or theophylline in adjunct with furosemide in paediatric populations: a systematic review and meta-analysis

The use of aminophylline or theophylline in adjunct with furosemide in paediatri

CRD42015026600

What is the optimum therapeutic range for theophyllines in children?

Asthma in children

CRD42021224952

Adding theophylline to ICS therapy on COPD: a protocol for systematic review and meta-analysis

Chronic obstructive pulmonary disease (COPD) is a common and frequently occurrin

📚 Sample References

PMID 24841445

Lung injury after simulated cardiopulmonary bypass in an isolated perfused rat lung preparation: Role of mitogen-activated protein kinase/Akt signaling and the effects of theophylline

J Thorac Cardiovasc Surg · 2014

PMID 32001318

Theophylline enhances melanogenesis in B16F10 murine melanoma cells through the activation of the MEK 1/2, and Wnt/β-catenin signaling pathways

Food Chem Toxicol · 2020

⚗️ All Ingredient data fields for Theophylline

⚗️ Identity

Name

Theophylline

Aliases / Synonyms

58-55-9; 1,3-Dimethylxanthine; Elixophyllin; Theophylline anhydrous; Theophyllin; Theolair; Nuelin; Respbid; Theocin

🧪 Chemistry

Molecular Weight

180.1670

LogP

-1.0397

Drug-likeness

0.562

H-Bond Acceptors

H-Bond Donors

🔬 Structures

Canonical SMILES

CN1C2=C(C(=O)N(C1=O)C)NC=N2

Isomeric SMILES

CN1C2=C(C(=O)N(C1=O)C)NC=N2

InChIKey

ZFXYFBGIUFBOJW-UHFFFAOYSA-N

InChI

InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)

🔗 External References

HERB DB

HBIN046282 ↗

PubChem CID

2153 ↗

DrugBank

DB00277 ↗

NPASS

NPC252603

HIT

C0443

TCMID

21296

TCM-ID

500

🔍 Raw view — every non-empty column on this row (31 fields)

name

Theophylline

common names

58-55-9; 1,3-Dimethylxanthine; Elixophyllin; Theophylline anhydrous; Theophyllin; Theolair; Nuelin; Respbid; Theocin

herb ingredient id

HBIN046282

canonical smiles

CN1C2=C(C(=O)N(C1=O)C)NC=N2

isomeric smiles

CN1C2=C(C(=O)N(C1=O)C)NC=N2

inchi

InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)

inchikey

ZFXYFBGIUFBOJW-UHFFFAOYSA-N

mol wt

180.1670

num h acceptors

num h donors

mol logp

-1.0397

num rotatable bonds

drug likeness

0.562

tcmid ingredient id

21296

tcm id ingredient id

500

pubchem cid

2153

drugbank id

DB00277

npass id

NPC252603

hit id

C0443

🏥 Linked Health Topics

7 · studied for these conditions (text bridge)

Congenital Heart Disease

group

High Altitude Pulmonary Hypertension

syndrome

Major Depressive Disorder

disease

📋 Clinical Trials

12 · subject of clinical study

NCT00983905 Drug-Drug Interaction Study of Colchicine and Theophylline

→ Pharmacokinetics

NCT01601132 Drug Interaction Study of Colchicine and Theophylline

→ Healthy

NCT00003684 Theophylline in Treating Cancer Patients With Shortness of Breath

→ Pulmonary Complications|Quality of Life|Unspecifie

NCT00003808 Theophylline in Treating Patients With In Situ, Stage I, or Stage II Chronic Lym

→ Leukemia

NCT00119496 Rosiglitazone Versus Theophylline in Asthmatic Smokers

→ Asthma

NCT00299858 Theophylline in Chronic Obstructive Pulmonary Disease

→ COPD

NCT00492518 Acetylcysteine, Theophylline, and a Combination of Both in the Prophylaxis of Co

→ Contrast Induced Nephropathy|Kidney Diseases|Renal

NCT00671151 Effects of Low-Dose Theophylline During Chronic Obstructive Pulmonary Disease (C

→ COPD

NCT00779259 Drug - Drug Interaction Study Between Quinine Sulfate and Theophylline

→ Pharmacokinetics

NCT01017939 A Drug-Drug Interaction Study of Abiraterone Acetate Plus Prednisone With Dextro

→ Prostate Neoplasms

NCT01132781 Theophylline in Rhinitis

→ Rhinosinusitis|Asthma|Allergic Rhinitis

NCT01263106 A Study of LY2216684 and Theophylline in Healthy Subjects

→ Major Depressive Disorder

📊 Meta-Analyses

5 · systematic review

CRD42022304383 The diuretic effect of aminophylline or theophylline in adjunct with furosemide

→ The use of aminophylline or theophylline in adjunc

CRD42015026600 What is the optimum therapeutic range for theophyllines in children?

→ Asthma in children

CRD42021224952 Adding theophylline to ICS therapy on COPD: a protocol for systematic review and

→ Chronic obstructive pulmonary disease (COPD) is a

CRD42017082794 Oral xanthine derivatives (theophylline and doxofylline) for patients with stabl

→ The Cochrane Airways Group

CRD42020196001 Effect of Low-dose Oral Theophylline as Additional Treatment on Exacerbations in

→ Theophylline, the most commonly used methylxanthin

📚 PubMed References

2 · cited research

PMID 24841445 Lung injury after simulated cardiopulmonary bypass in an isolated perfused rat l

J Thorac Cardiovasc Surg

PMID 32001318 Theophylline enhances melanogenesis in B16F10 murine melanoma cells through the

Food Chem Toxicol

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables