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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Trans-resveratrol

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

131

PubMed References

Top Conditions Studied with Trans-resveratrol

Healthy 5 Impaired Glucose Tolerance 2 Endothelial Dysfunction 2 Healthy, no Evidence of Disease 2 Pre-diabetes 2 Alzheimer's Disease 2 Friedreich Ataxia 2 Type 2 diabetes mellitus is a metabolic disease characterize 1 Obesity is a chronic disease that causes important changes i 1 Type 2 Diabetes 1 Infertility 1 Cognitive and Cerebral Blood Flow Effects of Resveratrol 1

📋 Sample Trials

NCT03090997

Effect of Resveratrol and Vitamin C on Insulin Resistance Among Postmenopausal Women

Unknown

NCT04867252

Effects of Combined Resveratrol and Myo-inositol on Altered Metabolic, Endocrine Parameters and Perceived Stress in Patients With Polycystic Ovarian Syndrome

Completed · Phase 2

NCT01324089

Resveratrol With or Without Piperine to Enhance Plasma Levels of Resveratrol

Completed

📊 Sample Meta-Analyses

CRD42021293495

Resveratrol and curcumin for Chagas Disease treatment. A Systematic Review

CRD42021266048

Effect and mechanisms of resveratrol in animal models of ischemic stroke: a systematic review and meta-analysis

CRD42022353317

Neuroprotective Effect and Possible Mechanisms of Resveratrol in Diabetes-Related Cognitive Impairment: A Systematic Review and Meta-Analysis of Animal Studies

📚 Sample References

PMID 31189495

Resveratrol attenuates high-fat diet-induced non-alcoholic steatohepatitis by maintaining gut barrier integrity and inhibiting gut inflammation through regulation of the endocannabinoid system

Clin Nutr · 2020

PMID 31294462

Resveratrol and HIV-protease inhibitors control UCP1 expression through opposite effects on p38 MAPK phosphorylation in human adipocytes

J Cell Physiol · 2020

PMID 31331257

Differential inhibitory effects of resveratrol on excitotoxicity and synaptic plasticity: involvement of NMDA receptor subtypes

Nutr Neurosci · 2021

⚗️ All Ingredient data fields for Trans-resveratrol

⚗️ Identity

Name

Trans-resveratrol

Aliases / Synonyms

resveratrol; 501-36-0; 3,4',5-Trihydroxystilbene; (E)-5-(4-Hydroxystyryl)benzene-1,3-diol; 3,5,4'-Trihydroxystilbene; (E)-resveratrol; Resvida; 3,4',5-Stilbenetriol; 5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol

🧪 Chemistry

Molecular Weight

228.2470

LogP

2.9738

Drug-likeness

0.692

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O

Isomeric SMILES

C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O)O)O

InChIKey

LUKBXSAWLPMMSZ-OWOJBTEDSA-N

InChI

InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+

🔗 External References

HERB DB

HBIN046831 ↗

PubChem CID

445154 ↗

DrugBank

DB02709 ↗

NPASS

NPC161571

HIT

C0363

SymMap

18307

TCMID

23118

🔍 Raw view — every non-empty column on this row (31 fields)

name

Trans-resveratrol

common names

herb ingredient id

HBIN046831

canonical smiles

C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O

isomeric smiles

C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O)O)O

inchi

InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+

inchikey

LUKBXSAWLPMMSZ-OWOJBTEDSA-N

mol wt

228.2470

num h acceptors

num h donors

mol logp

2.9738

num rotatable bonds

drug likeness

0.692

symmap mol id

18307

tcmid ingredient id

23118

pubchem cid

445154

drugbank id

DB02709

npass id

NPC161571

hit id

C0363

🏥 Linked Health Topics

12 · studied for these conditions (text bridge)

Amyotrophic Lateral Sclerosis

📋 Clinical Trials

12 · subject of clinical study

NCT03090997 Effect of Resveratrol and Vitamin C on Insulin Resistance Among Postmenopausal W

→ Postmenopausal|Insulin Resistance

NCT04867252 Effects of Combined Resveratrol and Myo-inositol on Altered Metabolic, Endocrine

→ PCOS

NCT01324089 Resveratrol With or Without Piperine to Enhance Plasma Levels of Resveratrol

→ Focus of the Study: Normal Volunteers

NCT00098969 UMCC 2003-064 Resveratrol in Preventing Cancer in Healthy Participants

→ Unspecified Adult Solid Tumor, Protocol Specific

NCT00256334 Resveratrol for Patients With Colon Cancer

→ Colon Cancer|Cancer

NCT00433576 Resveratrol in Treating Patients With Colorectal Cancer That Can Be Removed By S

→ Adenocarcinoma of the Colon|Adenocarcinoma of the

NCT00721877 Resveratrol in Healthy Adult Participants

→ Healthy, no Evidence of Disease

NCT01126229 Resveratrol for Improved Performance in the Elderly

→ Memory

NCT01150955 Potential Beneficial Effects of Resveratrol

→ Metabolic Syndrome|Obesity

NCT01173640 Resveratrol and Midazolam Metabolism

→ Healthy

NCT01321151 Use of Resveratrol to Decrease Acute Secondary Brain Injury Following Sports-Rel

→ Sports Concussion

NCT01339884 A Study of Resveratrol as Treatment for Friedreich Ataxia

→ Friedreich Ataxia

📊 Meta-Analyses

12 · systematic review

CRD42021293495 Resveratrol and curcumin for Chagas Disease treatment. A Systematic Review

CRD42021266048 Effect and mechanisms of resveratrol in animal models of ischemic stroke: a syst

CRD42022353317 Neuroprotective Effect and Possible Mechanisms of Resveratrol in Diabetes-Relate

CRD42013003652 Effects of resveratrol on human health: a meta-analysis of clinical trials

→ All clinical trials.

CRD42014012844 Tissue distribution of resveratrol

→ There is no specific condition being studied, but

CRD42014014431 Effects of resveratrol on some risk for developing type 2 diabetes: A systematic

→ Although resveratrol has been widely studied for i

CRD42015029273 Effects of supplementation with resveratrol on the parameters of Non-Alcoholic F

→ Non-alcoholic fatty liver disease (NAFLD) is chara

CRD42016036815 Resveratrol for treatment of type 2 diabetes mellitus [Cochrane Protocol]

→ The Cochrane Metabolic and Endocrine Disorders Gro

CRD42016045395 Does resveratrol supplementation alter plasma adiponectin and leptin concentrati

→ Plasma concentrations of adiponectin and leptin.

CRD42016047548 The effect of resveratrol exposure during pregnancy on both maternal and fetal o

→ Maternal and fetal outcomes after resveratrol expo

CRD42017055636 Resveratrol supplementation and inflammatory biomarkers: a systematic review and

→ Plasma concentrations of CRP, IL-1b, IL-6, IL-8, I

CRD42017067493 Effect of resveratrol on lipid profile: a systematic review and meta-analysis

→ In this study we want to find a herbal and safe me

📚 PubMed References

12 · cited research

PMID 31189495 Resveratrol attenuates high-fat diet-induced non-alcoholic steatohepatitis by ma

Clin Nutr

PMID 31294462 Resveratrol and HIV-protease inhibitors control UCP1 expression through opposite

J Cell Physiol

PMID 31331257 Differential inhibitory effects of resveratrol on excitotoxicity and synaptic pl

Nutr Neurosci

PMID 31664166 Mechanism and therapeutic prospect of resveratrol combined with TRAIL in the tre

Cancer Gene Ther

PMID 31667715 Resveratrol Activates Neuronal Autophagy Through AMPK in the Ischemic Brain

Mol Neurobiol

PMID 31704236 Resveratrol promotes HSV-2 replication by increasing histone acetylation and act

Biochem Pharmacol

PMID 31712163 Resveratrol induces depletion of TRAF6 and suppresses prostate cancer cell proli

Int J Biochem Cell Biol

PMID 31838177 Resveratrol alleviates non-alcoholic fatty liver disease through epigenetic modi

Int J Biochem Cell Biol

PMID 31863772 Resveratrol bidirectionally regulates insulin effects in skeletal muscle through

Life Sci

PMID 31881225 miR-139-mediated NOTCH1 regulation is crucial for the inhibition of osteosarcoma

Life Sci

PMID 31883358 Resveratrol ameliorates rheumatoid arthritis via activation of SIRT1-Nrf2 signal

Biofactors

PMID 31884092 Resveratrol ameliorates metabolic disorders and insulin resistance in high-fat d

Life Sci

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables