Relationship Graph Explorer

Follow the connections

Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

🌿

Herb

→

→

→

→

🧪

Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Tryptophane

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Tryptophane

Healthy 2 Breast cancer is a heterogeneous group of diseases, with dif 1 Cerebral Infarction 1 Attention Deficit/Hyperactivity Disorder (ADHD) is character 1 Bipolar Disorder 1 Alcohol is the most extensive addictive substance in the wor 1 Tryptophan Pathway 1 Sleep quality outcomes (e.g. sleep duration, sleep latency, 1 Sleep|Mood|Burnout|Melatonin Deficiency|Cortisol Deficiency 1 Pregnant women without any restriction regarding study setti 1 Schizophrenia 1 Peripartum period, pregnancy Postpartum depression / postpar 1

📋 Sample Trials

NCT00000324

Tryptophan and Behavior Therapy for Cocaine Abuse - 1

Completed · Phase 2

NCT00192725

Tryptophan Depletion in Acute Mania

Completed

NCT02067975

Tryptophan MRI in People With Schizophrenia and Healthy Controls

Completed · Phase 2|Phase 3

📊 Sample Meta-Analyses

CRD42021273120

The role of the tryptophan and kynurenine pathway in maternal, foetal and placental health, and pregnancy outcome: a systematic review

Pregnant women without any restriction regarding study setting (such as first-li

CRD42020159274

Dysregulation of tryptophan-kynurenine pathway associated metabolites in patients with dementia or cognitive impairment: a meta-analysis

Dementia, cognitive and affective symptomology, and aging. Dementia is an overal

CRD42021252462

Tryptophan levels and its metabolites in the pathogenesis of postpartum blues and postpartum depression: a meta-analysis and systematic review

Peripartum period, pregnancy Postpartum depression / postpartum blues, maternal

📚 Sample References

PMID 34326168

Tryptophan potentiates CD8+ T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation

J Immunother Cancer · 2021

⚗️ All Ingredient data fields for Tryptophane

⚗️ Identity

Name

Tryptophane

Aliases / Synonyms

L-tryptophan; tryptophan; 73-22-3; h-Trp-oh; L-Tryptophane; (S)-Tryptophan; trofan; tryptacin; Ardeytropin

🧪 Chemistry

Molecular Weight

204.2290

LogP

1.1223

Drug-likeness

0.701

Oral Bioavailability

28.5550

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)N

Isomeric SMILES

C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)O)N

InChIKey

QIVBCDIJIAJPQS-VIFPVBQESA-N

InChI

InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1

🔗 External References

HERB DB

PubChem CID

CAS Number

DrugBank

SymMap

691

TCMID

32161; 33387

TCMSP

MOL007344

🔍 Raw view — every non-empty column on this row (32 fields)

name

Tryptophane

common names

L-tryptophan; tryptophan; 73-22-3; h-Trp-oh; L-Tryptophane; (S)-Tryptophan; trofan; tryptacin; Ardeytropin

herb ingredient id

HBIN047282

canonical smiles

C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)N

isomeric smiles

C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)O)N

inchi

InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1

inchikey

QIVBCDIJIAJPQS-VIFPVBQESA-N

mol wt

204.2290

num h acceptors

num h donors

mol logp

1.1223

num rotatable bonds

drug likeness

0.701

ob score

28.5550

cas id

7331-08-0

symmap mol id

691

tcmid ingredient id

32161; 33387

tcmsp ingredient id

MOL007344

pubchem cid

6305

drugbank id

DB00150

🏥 Linked Health Topics

5 · diseases via target pathways

Cocaine-Related Disorders

group

📋 Clinical Trials

11 · subject of clinical study

NCT00000324 Tryptophan and Behavior Therapy for Cocaine Abuse - 1

→ Cocaine-Related Disorders

NCT00192725 Tryptophan Depletion in Acute Mania

→ Bipolar Disorder

NCT02067975 Tryptophan MRI in People With Schizophrenia and Healthy Controls

→ Schizophrenia

NCT02402179 Metabolic Availability of Tryptophan From White Maize

→ Healthy

NCT03017768 The Effect of Acute Tryptophan Depletion (ATD) on Esophageal Sensitivity in Heal

→ Esophageal Sensitivity

NCT04505800 Tryptophan Supplementation to Improve Night Shift Workers' Health

→ Sleep|Mood|Burnout|Melatonin Deficiency|Cortisol D

NCT00865202 A Placebo Controlled Trial Of L-Tryptophan In Post-Operative Delirium

→ Post-operative Delirium

NCT02018588 Tryptophan Requirement of Healthy School Age Children

→ Healthy

NCT02612259 A Phase II, Randomized, Double-blind, Placebo-controlled, in Parallel Groups Cli

→ Obesity

NCT02963545 TSK (Tryptophan - Serotonin - Kynurenine) Biomarkers Assessment in Stroke

→ Cerebral Infarction

NCT04466436 Anaesthesia and Tryptophan Pathway

→ Tryptophan Pathway

📊 Meta-Analyses

10 · systematic review

CRD42021273120 The role of the tryptophan and kynurenine pathway in maternal, foetal and placen

→ Pregnant women without any restriction regarding s

CRD42020159274 Dysregulation of tryptophan-kynurenine pathway associated metabolites in patient

→ Dementia, cognitive and affective symptomology, an

CRD42021252462 Tryptophan levels and its metabolites in the pathogenesis of postpartum blues an

→ Peripartum period, pregnancy Postpartum depression

CRD42022352070 Melatonin and tryptophan influence on sleep quality in women undergoing breast c

→ Breast cancer is a heterogeneous group of diseases

CRD42020160043 The impact of tryptophan supplementation on sleep quality: a systematic review

→ Sleep quality outcomes (e.g. sleep duration, sleep

CRD42020188649 A systematic review of the use of tryptophan as a treatment for Attention Defici

→ Attention Deficit/Hyperactivity Disorder (ADHD) is

CRD42021278725 Effects of Tryptophan Supplementation on Depressive Disorder: Systematic Review

→ Depression is one of the most common and frequent

CRD42022357640 Tryptophan catabolite changes in alcoholism: a systematic review and meta-analys

→ Alcohol is the most extensive addictive substance

CRD42023388936 The effects of changes in the concentration of tryptophan derivatives on chronic

→ Chronic pain is a prevalent affliction that greatl

CRD42023459005 Role of dietary supplements in type 2 diabetes mellitus with coronary heart dise

→ Outcomes associated with populations in type 2 dia

📚 PubMed References

1 · cited research

PMID 34326168 Tryptophan potentiates CD8+ T cells against cancer cells by TRIP12 tryptophanyla

J Immunother Cancer

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables