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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Ur

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Ur

Hepatocellular Carcinoma 2 Acute, non-hypovolemic hyponatremia among hospitalized adult 1 Diabetic Kidney Disease 1 Urea breath test (UBT) is a commonly used non-invasive test 1 Acanthosis Nigricans(AN) is a skin condition that manifests 1 Acute Kidney Injury 1 Syndrome of Inappropriate Antidiuretic Hormone Secretion 1 Xerosis Cutis 1 Sorafenib is a multitargeted tyrosine kinase inhibitor, whic 1 Radiodermatitis 1 Premature rupture of membranes (PROM) occurs in 10% of all p 1 Hyponatremia|Subarachnoid Hemorrhage|SIADH 1

📋 Sample Trials

NCT03376620

Role of Topical Putrescine (Fibrostat) for Prevention of Hypertrophic Scars in Mammoplasty Patients

Completed · Phase 3

NCT04127513

Comparison of 12% Ammonium Lactate and 10% Urea Cream in Geriatric With Xerosis Cutis

Completed · Phase 3

NCT04552873

Urea Therapy for Hyponatremia in Subarachnoid Hemorrhage

Recruiting

📊 Sample Meta-Analyses

CRD42020141800

Vaginal fluid urea and creatinine in the diagnosis of premature rupture of membranes. A systematic review

Premature rupture of membranes (PROM) occurs in 10% of all pregnancies and about

CRD42022376344

Association between Urinary Albumin-creatinine Ratio (UACR) and Risk of Cardiovascular Disease and Mortality: A Systematic Review and Meta-analysis of Prospective Studies

Cardiovascular Disease and Mortality

CRD42019111706

The effect of Lepidium meyenii polysaccharide on fatigue: a systematic review

Lepidium meyenii, scientific name of Maca, is a plant native to the Peruvian And

📚 Sample References

None linked yet.

⚗️ All Ingredient data fields for Ur

⚗️ Identity

Name

Aliases / Synonyms

urea; 57-13-6; carbamide; Isourea; Carbonyldiamide; Ureophil; Carbonyldiamine; Ureaphil; Carbamimidic acid; Urevert

🧪 Chemistry

Molecular Weight

60.0560

LogP

-0.9762

Drug-likeness

0.371

Oral Bioavailability

26.4560

H-Bond Acceptors

H-Bond Donors

🔬 Structures

Canonical SMILES

C(=O)(N)N

Isomeric SMILES

C(=O)(N)N

InChIKey

XSQUKJJJFZCRTK-UHFFFAOYSA-N

InChI

InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)

🔗 External References

HERB DB

PubChem CID

CAS Number

DrugBank

NPASS

NPC142330

HIT

C0470

SymMap

13750

TCMSP

MOL013046

🔍 Raw view — every non-empty column on this row (33 fields)

name

common names

urea; 57-13-6; carbamide; Isourea; Carbonyldiamide; Ureophil; Carbonyldiamine; Ureaphil; Carbamimidic acid; Urevert

herb ingredient id

HBIN047559

canonical smiles

C(=O)(N)N

isomeric smiles

C(=O)(N)N

inchi

InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)

inchikey

XSQUKJJJFZCRTK-UHFFFAOYSA-N

mol wt

60.0560

num h acceptors

num h donors

mol logp

-0.9762

num rotatable bonds

drug likeness

0.371

ob score

26.4560

cas id

4744-36-9

symmap mol id

13750

tcmsp ingredient id

MOL013046

pubchem cid

1176

drugbank id

DB03904

npass id

NPC142330

hit id

C0470

🏥 Linked Health Topics

2 · diseases via target pathways

Acute Kidney Injury

disease

Hepatocellular carcinoma

disease

📋 Clinical Trials

12 · subject of clinical study

NCT03376620 Role of Topical Putrescine (Fibrostat) for Prevention of Hypertrophic Scars in M

→ Hypertrophic Scar

NCT04127513 Comparison of 12% Ammonium Lactate and 10% Urea Cream in Geriatric With Xerosis

→ Xerosis Cutis

NCT04552873 Urea Therapy for Hyponatremia in Subarachnoid Hemorrhage

→ Hyponatremia|Subarachnoid Hemorrhage|SIADH

NCT04588207 Urea for Chronic Hyponatremia

→ Hyponatremia|Inappropriate ADH Syndrome

NCT02111148 Vaginal Fluid Wash in Pre-labour Rupture of Membranes

→ Disorder of Amniotic Cavity and/or Membrane

NCT04612595 The Association Between sUCR and the Survival in Patients With DKD

→ Diabetic Kidney Disease

NCT02249884 Dose-Response Curve: Interventions to Prevent and Treat Radiodermatitis

→ Radiodermatitis

NCT02705664 Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus a Tw

→ Foot Dermatoses

NCT03763188 Dialysis Weaning in Intensive Care Units (Dialysis STOP)

→ Acute Kidney Injury

NCT01934829 Urea Cream Treatment Sorafenib-Associated HSFR in HCC

→ Hepatocellular Carcinoma

NCT03212625 The Effect of Urea Cream on Sorafenib-associated Hand-Foot Skin Reaction

→ Hepatocellular Carcinoma

NCT05348278 Urea Cream Prevention for Capecitabine Associated Hand Foot Syndrome

→ Hand-Foot Syndrome

📊 Meta-Analyses

12 · systematic review

CRD42020141800 Vaginal fluid urea and creatinine in the diagnosis of premature rupture of membr

→ Premature rupture of membranes (PROM) occurs in 10

CRD42022376344 Association between Urinary Albumin-creatinine Ratio (UACR) and Risk of Cardiova

→ Cardiovascular Disease and Mortality

CRD42019111706 The effect of Lepidium meyenii polysaccharide on fatigue: a systematic review

→ Lepidium meyenii, scientific name of Maca, is a pl

CRD42019127987 Oral urea supplementation in the treatment of hyponatremia among hospitalized ad

→ Acute, non-hypovolemic hyponatremia among hospital

CRD42020179613 A meta-analysis of the predictive value of blood urea nitrogen on mortality in c

→ Critical illness, including heart failure, acute r

CRD42020203164 Effect of Urea cream on Hand Foot Syndrome in Patients receiving Chemotherapy: A

→ hand foot syndrome, condition of skin

CRD42021213569 Urea for Syndrome of Inappropriate Antidiuretic Hormone Secretion

→ Syndrome of Inappropriate Antidiuretic Hormone Sec

CRD42021272076 Optimal cut-off values for diagnosing helicobacter pylori infection with urea br

→ Helicobacter pylori infection remains one of the m

CRD42021275651 Prophylactic Effect of Urea-Based Cream and Celecoxib on Chemotherapy-Induced Ha

→ Chemotherapy induced hand-foot syndrome

CRD42022340121 Effectiveness of Urea-Based Cream and Pyridoxine(vitamin B6) on Sorafenib-induce

→ Sorafenib is a multitargeted tyrosine kinase inhib

CRD42022354308 Systematic Review and Meta-Analysis on the Accuracy of 13C UBT and 14C UBT Urea

→ Urea breath test (UBT) is a commonly used non-inva

CRD42023444441 Comparison on the Effectiveness of different Treatment modalities for Acanthosis

→ Acanthosis Nigricans(AN) is a skin condition that

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables