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trials · metas · refs
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⚗️ Ingredient

Urc

Open on HERB 2.0 ↗
3
Clinical Trials
26
Meta-Analyses
1
PubMed References
Top Conditions Studied with Urc
Hyperuricemia is a metabolic problem that has become increas 1 Gestational Diabetes 1 The definition of chronic kidney disease (CKD) consists of p 1 Heart Failure and Hyperuricemia. Serum uric acid, heart func 1 Acute Ischemic Stroke 1 Sarcopenia is a progressive and generalized skeletal muscle 1 heart failure 1 Pulse Wave Velocity 1 Diabetes is one of the leading public health problems around 1 Periodontitis. 1 Chronic kidney disease. Hyperuricaemia. 1 Management of chronic kidney disease. 1
📋 Sample Trials
NCT00860366
Efficacy Study of Combined Treatment With Uric Acid and rtPA in Acute Ischemic Stroke
Completed · Phase 2|Phase 3
NCT04956094
GGT and Uric Acid to Predict Gestational Diabetes Mellitus
Recruiting
NCT01323335
The Relationship Between Uric Acid and Inflammatory Markers
Completed · Phase 1
📊 Sample Meta-Analyses
CRD42020209883
Systematic review and meta-analysis of the effect of uric acid lowering treatment in patients with heart failure.
Heart Failure and Hyperuricemia. Serum uric acid, heart function and other progn
CRD42020160968
The Effect of Uric Acid Level, Hyperuricemia and Gout on Risk of Type 2 Diabetes: A Meta-analysis Based on Cohort Studies
Diabetes is one of the leading public health problems around the world. There we
CRD42022331785
Uric Acid is Associated with The Severity in IBD: A Meta-Analysis
Inflammatory bowel disease includes two major disease: ulcerative colitis and Cr
📚 Sample References
PMID 32991862
Effects of high-dose uric acid on cellular proteome, intracellular ATP, tissue repairing capability and calcium oxalate crystal-binding capability of renal tubular cells: Implications to hyperuricosuria-induced kidney stone disease
Chem Biol Interact · 2020
⚗️ All Ingredient data fields for Urc
⚗️ Identity
Name
Urc
Aliases / Synonyms
uric acid; 69-93-2; urate; Lithic acid; 2,6,8-trioxypurine; 2,6,8-trihydroxypurine; 8-hydroxyxanthine; 7,9-Dihydro-1H-purine-2,6,8(3H)-trione; 2,6,8-Trioxopurine; 1H-Purine-2,6,8(3H)-trione, 7,9-dihydro-
🧪 Chemistry
Molecular Weight
168.1120
LogP
-1.7672
Drug-likeness
0.373
Oral Bioavailability
48.7660
H-Bond Acceptors
3
H-Bond Donors
4
🔬 Structures
Canonical SMILES
C12=C(NC(=O)N1)NC(=O)NC2=O
Isomeric SMILES
C12=C(NC(=O)N1)NC(=O)NC2=O
InChIKey
LEHOTFFKMJEONL-UHFFFAOYSA-N
InChI
InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)
🔗 External References
HERB DB
HBIN047572 ↗
PubChem CID
1175 ↗
CAS Number
13154-20-6 ↗
DrugBank
DB08844 ↗
NPASS
NPC5707
SymMap
10836
TCMSP
MOL009750
🔍 Raw view — every non-empty column on this row (32 fields)
name
Urc
common names
uric acid; 69-93-2; urate; Lithic acid; 2,6,8-trioxypurine; 2,6,8-trihydroxypurine; 8-hydroxyxanthine; 7,9-Dihydro-1H-purine-2,6,8(3H)-trione; 2,6,8-Trioxopurine; 1H-Purine-2,6,8(3H)-trione, 7,9-dihydro-
herb ingredient id
HBIN047572
canonical smiles
C12=C(NC(=O)N1)NC(=O)NC2=O
isomeric smiles
C12=C(NC(=O)N1)NC(=O)NC2=O
inchi
InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)
inchikey
LEHOTFFKMJEONL-UHFFFAOYSA-N
mol wt
168.1120
num h acceptors
3
num h donors
4
mol logp
-1.7672
num rotatable bonds
0
drug likeness
0.373
ob score
48.7660
cas id
13154-20-6
symmap mol id
10836
tcmsp ingredient id
MOL009750
pubchem cid
1175
drugbank id
DB08844
npass id
NPC5707

🏥 Linked Health Topics

1 · studied for these conditions (text bridge)
Gestational Diabetes
phenotype

📋 Clinical Trials

3 · subject of clinical study
NCT00860366 Efficacy Study of Combined Treatment With Uric Acid and rtPA in Acute Ischemic S
→ Acute Ischemic Stroke
NCT04956094 GGT and Uric Acid to Predict Gestational Diabetes Mellitus
→ Gestational Diabetes
NCT01323335 The Relationship Between Uric Acid and Inflammatory Markers
→ Healthy Volunteers

📊 Meta-Analyses

12 · systematic review
CRD42020209883 Systematic review and meta-analysis of the effect of uric acid lowering treatmen
→ Heart Failure and Hyperuricemia. Serum uric acid,
CRD42020160968 The Effect of Uric Acid Level, Hyperuricemia and Gout on Risk of Type 2 Diabetes
→ Diabetes is one of the leading public health probl
CRD42022331785 Uric Acid is Associated with The Severity in IBD: A Meta-Analysis
→ Inflammatory bowel disease includes two major dise
CRD42016038030 Effect of uric acid-lowering therapy on cardiovascular and renal outcomes in pat
→ Management of chronic kidney disease.
CRD42016044028 Association between uric acid and arterial stiffness in general adults: a system
CRD42017053748 Uric acid and chronic kidney disease: a systematic review of observational studi
→ Chronic kidney disease.
CRD42018081155 Effect of uric acid lowering drugs on preventing or slowing the progression of d
→ There is increasing recognition of the links betwe
CRD42018090397 Association between uric acid and pulse wave velocity in hypertensive patients a
→ Pulse Wave Velocity
CRD42019128381 Uric acid and risk of heart failure mortality: a dose-response meta-analysis of
→ heart failure
CRD42019140346 The effect of uric acid-lowering therapy on kidney function among patients with
→ Although the uric acid-lowering therapy is effecti
CRD42020142073 The role of uric acid in chronic kidney disease
→ The definition of chronic kidney disease (CKD) con
CRD42020163427 The effect of uric acid-lowering therapies on the development and progression of
→ Chronic kidney disease. Asymptomatic hyperuricaemi

📚 PubMed References

1 · cited research
PMID 32991862 Effects of high-dose uric acid on cellular proteome, intracellular ATP, tissue r
Chem Biol Interact
How relationships are computed
  • Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
  • Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
  • Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
  • Ingredient ↔ Target: empty — needs HERB_ingredient_target import
  • Target ↔ Disease: empty — needs HERB_target_disease import
  • Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables