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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Ursodeoxycholic acid

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Ursodeoxycholic acid

Primary Biliary Cholangitis 4 Healthy 3 Liver Cirrhosis, Biliary 2 Primary Biliary Cirrhosis 2 Cholestasis is a common pediatric disease with an incidence 1 Fibrosis, Liver 1 Rheumatoid Arthritis 1 Bone Regeneration 1 Primary biliary cirrhosis; bezafibrate; ursodeoxycholic acid 1 Liver Transplantation|Ischemia-reperfusion Injury|Cholestasi 1 Cholelithiasis is highly incident after bariatric surgery, r 1 Diarrhea 1

📋 Sample Trials

NCT03659058

Impact of Ursodeoxycholic Acid, Silymarin, Antioxidants and Colchicine on Fibrosis Regression in HCV After SVR

Completed

NCT01857284

Safety and Efficacy of Tauroursodeoxycholic Acid Versus Ursofalk in the Treatment of Adult Primary Biliary Cirrhosis

Completed · Phase 3

NCT00200343

Efficacy and Safety Study of Ursodeoxycholic Acid to Treat Chronic Hepatitis C

Completed · Phase 3

📊 Sample Meta-Analyses

CRD42022343104

Role of Ursodeoxycholic acid in preventing parenteral nutrition associated liver disease in neonates

Neonates with TPN induced cholestasis and UCDA

CRD42021266663

Role of Ursodeoxycholic Acid in Neonatal Indirect Hyperbilirubinemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Neonatal jaundice is a hyperbilirubinemia manifesting as a yellowish discolorati

CRD42021223744

Effects of ursodeoxycholic acid and its taurine/glycine conjugated species on apoptosis, oxidative stress and inflammation in the brain: A systematic review

📚 Sample References

PMID 31812332

Increased p16INK4a-expressing senescent bile ductular cells are associated with inadequate response to ursodeoxycholic acid in primary biliary cholangitis

J Autoimmun · 2020

PMID 31960968

Ursodeoxycholic acid attenuates the expression of proinflammatory cytokines in periodontal cells

J Periodontol · 2020

PMID 31985529

Ursodeoxycholic Acid Treatment Preferentially Improves Overall Survival Among African Americans With Primary Biliary Cholangitis

Am J Gastroenterol · 2020

⚗️ All Ingredient data fields for Ursodeoxycholic acid

⚗️ Identity

Name

Ursodeoxycholic acid

Aliases / Synonyms

ursodiol; 128-13-2; Actigall; ursodeoxycholate; UDCA; Ursofalk; Ursolvan; Ursodesoxycholic acid; UrSO

🧪 Chemistry

Molecular Weight

392.5800

LogP

4.4779

Drug-likeness

0.659

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC(CCC(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C

Isomeric SMILES

C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C

InChIKey

RUDATBOHQWOJDD-UZVSRGJWSA-N

InChI

InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20+,22+,23+,24-/m1/s1

🔗 External References

HERB DB

HBIN047610 ↗

PubChem CID

31401 ↗

NPASS

NPC171426

HIT

C0475

TCMID

23036; 22253

TCM-ID

252

🔍 Raw view — every non-empty column on this row (30 fields)

name

Ursodeoxycholic acid

common names

ursodiol; 128-13-2; Actigall; ursodeoxycholate; UDCA; Ursofalk; Ursolvan; Ursodesoxycholic acid; UrSO

herb ingredient id

HBIN047610

canonical smiles

CC(CCC(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C

isomeric smiles

C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C

inchi

InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20+,22+,23+,24-/m1/s1

inchikey

RUDATBOHQWOJDD-UZVSRGJWSA-N

mol wt

392.5800

num h acceptors

num h donors

mol logp

4.4779

num rotatable bonds

drug likeness

0.659

tcmid ingredient id

23036; 22253

tcm id ingredient id

252

pubchem cid

31401

npass id

NPC171426

hit id

C0475

🏥 Linked Health Topics

10 · studied for these conditions (text bridge)

Rheumatoid Arthritis

syndrome

Primary Biliary Cirrhosis

Rhegmatogenous Retinal Detachment

syndrome

Non-Alcoholic Fatty Liver Disease

syndrome

Primary Sclerosing Cholangitis

syndrome

📋 Clinical Trials

12 · subject of clinical study

NCT03659058 Impact of Ursodeoxycholic Acid, Silymarin, Antioxidants and Colchicine on Fibros

→ Fibrosis, Liver

NCT01857284 Safety and Efficacy of Tauroursodeoxycholic Acid Versus Ursofalk in the Treatmen

→ Primary Biliary Cirrhosis

NCT00200343 Efficacy and Safety Study of Ursodeoxycholic Acid to Treat Chronic Hepatitis C

→ Chronic Hepatitis C

NCT01073202 Effects of Ursodeoxycholic Acid on Graft Recovery Early After Adult Liver Transp

→ Liver Transplantation|Ischemia-reperfusion Injury|

NCT01088607 Safety and Efficacy Study of Ursodeoxycholic Acid Therapy in Pediatric Primary S

→ Primary Sclerosing Cholangitis

NCT01149304 Preventive Effect of Enoxaparin, Pentoxifylline and Ursodeoxycholic Acid to Radi

→ Colorectal Cancer|Liver Metastases|Irradiation Dam

NCT01548079 Ursodeoxycholic Acid in Bariatric Surgery

→ Non-alcoholic Fatty Liver Disease|Morbid Obesity

NCT01576458 Ursodeoxycholic Acid in the Treatment of Intrahepatic Cholestasis of Pregnancy

→ Intrahepatic Cholestasis|Pregnancy

NCT01904058 Phase 2 Study to Evaluate LUM001 in Combination With Ursodeoxycholic Acid in Pat

→ PBC|Primary Biliary Cirrhosis

NCT01974336 The Preventative and Therapeutical Effect of Ursodeoxycholic Acid(UDCA) to Short

→ Short Bowel Syndrome

NCT02021110 Ursodeoxycholic Acid as Treatment for Polycystic Liver Disease

→ Polycystic Liver Disease|Polycystic Kidney, Autoso

NCT02841306 Ursodeoxycholic Acid for Rhegmatogenous Retinal Detachment

→ Rhegmatogenous Retinal Detachment

📊 Meta-Analyses

12 · systematic review

CRD42022343104 Role of Ursodeoxycholic acid in preventing parenteral nutrition associated liver

→ Neonates with TPN induced cholestasis and UCDA

CRD42021266663 Role of Ursodeoxycholic Acid in Neonatal Indirect Hyperbilirubinemia: A Systemat

→ Neonatal jaundice is a hyperbilirubinemia manifest

CRD42021223744 Effects of ursodeoxycholic acid and its taurine/glycine conjugated species on ap

CRD42021234064 Ursodeoxycholic acid in the treatment of neonatal jaudice:a systematic review an

→ Neonatal hyperbilirubinemia is one of the most com

CRD42022326534 Effect of ursodeoxycholic acid on the outcome of biliary atresia: A systematic r

→ Biliary atresia (BA) is a common hepatic disease a

CRD42022354052 Efficacy and safety of ursodeoxycholic acid in children with cholestasis: a syst

→ Cholestasis is a common pediatric disease with an

CRD42022382186 Efficacy of ursodeoxycholic acid on the clinical outcomes of patients with COVID

→ The COVID-19 infection, which was initially discov

CRD42022324490 Ursodeoxycholic acid plus mosapride in patients with bile reflux gastritis:A met

→ Bile reflux gastritis is a disease in which bile r

CRD42021276719 Role of Ursodeoxycholic acid in prevention of gallstones formation in bariatric

→ Gallstone disease, bariatric surgery

CRD42021276554 Effect of Ursodeoxycholic Acid on development of Cholangiocarcinoma in patients

→ Cholangiocarcinoma in patients with Primary Sclero

CRD42021267689 The role of Ursodeoxycholic acid in the management of upper gastrointestinal dis

→ Upper gastrointestinal diseases in adults.

CRD42020189818 Preventive Role of Ursodeoxycholic Acid on Cholelithiasis following laparoscopic

→ Cholelithiasis is highly incident after bariatric

📚 PubMed References

7 · cited research

PMID 31812332 Increased p16INK4a-expressing senescent bile ductular cells are associated with

J Autoimmun

PMID 31960968 Ursodeoxycholic acid attenuates the expression of proinflammatory cytokines in p

J Periodontol

PMID 31985529 Ursodeoxycholic Acid Treatment Preferentially Improves Overall Survival Among Af

Am J Gastroenterol

PMID 32004633 Ursodeoxycholic acid protects against cisplatin-induced acute kidney injury and

Free Radic Biol Med

PMID 33178028 Ursodeoxycholic Acid Protects Against Arsenic Induced Hepatotoxicity by the Nrf2

Front Pharmacol

PMID 33710617 Ursodeoxycholic acid impairs liver-infiltrating T-cell chemotaxis through IFN-γ

Eur J Immunol

PMID 35701426 Ursodeoxycholic acid reduces antitumor immunosuppression by inducing CHIP-mediat

Nat Commun

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables