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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Vinblastine

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Vinblastine

Lymphoma 3 Melanoma|Skin Cancer 2 Melanoma (Skin) 2 Classical Hodgkin Lymphoma 2 Hodgkin's Disease 1 Ann Arbor Stage I Hodgkin Lymphoma|Ann Arbor Stage IA Hodgki 1 Recurrent Lymphoma|Refractory Lymphoma|Solid Tumours|Central 1 Hodgkin Lymphoma 1 AML|Hyperleukocytosis 1 Prostate Cancer 1 Hodgkin Disease 1 Neurofibromatosis Type 1|Precancerous Condition 1

📋 Sample Trials

NCT03092986

Outcome of Cisplatin and Vinblastine Versus Paclitaxel and Carboplatin as Sequential Chemotherapy Followed by Radiotherapy in Locally Advanced Non-small Cell Lung Cancer

Completed · Phase 4

NCT00001570

A Phase I Study of Continuous Intravenous Infusion of PSC 833 and Vinblastine in Patients With Metastatic Renal Cancer

Completed · Phase 1

NCT00002495

SWOG-9133 RT w/ or w/o Doxorubicin and Vinblastine in Stage I or Stage II Hodgkin's Disease

Completed · Phase 3

📊 Sample Meta-Analyses

None linked yet.

📚 Sample References

PMID 30082792

A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine

Nat Commun · 2018

PMID 27270426

The ERK-ZEB1 pathway mediates epithelial-mesenchymal transition in pemetrexed resistant lung cancer cells with suppression by vinca alkaloids

Oncogene · 2017

PMID 35127485

Neutralizing Anti-IL-17A Antibody Demonstrates Preclinical Activity Enhanced by Vinblastine in Langerhans Cell Histiocytosis

Front Oncol · 2022

⚗️ All Ingredient data fields for Vinblastine

⚗️ Identity

Name

Vinblastine

Aliases / Synonyms

865-21-4; Vinblastin; Vincaleucoblastin; Vincaleukoblastine; Vinblastina; Vincoblastine; Rozevin; Nincaluicolflastine; Vinblastinum

🧪 Chemistry

Molecular Weight

810.9890

LogP

3.9909

Drug-likeness

0.18

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O

Isomeric SMILES

CC[C@@]1(C[C@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O

InChIKey

JXLYSJRDGCGARV-CFWMRBGOSA-N

InChI

InChI=1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1

🔗 External References

HERB DB

PubChem CID

CAS Number

DrugBank

TCMID

22471

TCM-ID

189

🔍 Raw view — every non-empty column on this row (30 fields)

name

Vinblastine

common names

865-21-4; Vinblastin; Vincaleucoblastin; Vincaleukoblastine; Vinblastina; Vincoblastine; Rozevin; Nincaluicolflastine; Vinblastinum

herb ingredient id

HBIN047936

canonical smiles

CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O

isomeric smiles

CC[C@@]1(C[C@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O

inchi

inchikey

JXLYSJRDGCGARV-CFWMRBGOSA-N

mol wt

810.9890

num h acceptors

num h donors

mol logp

3.9909

num rotatable bonds

drug likeness

0.18

cas id

865-21-4

tcmid ingredient id

22471

tcm id ingredient id

189

pubchem cid

13342

drugbank id

DB00570

🏥 Linked Health Topics

5 · studied for these conditions (text bridge)

📋 Clinical Trials

12 · subject of clinical study

NCT03092986 Outcome of Cisplatin and Vinblastine Versus Paclitaxel and Carboplatin as Sequen

→ Carcinoma, Non-Small-Cell Lung

NCT00001570 A Phase I Study of Continuous Intravenous Infusion of PSC 833 and Vinblastine in

→ Kidney Neoplasms|Neoplasm Metastasis

NCT00002495 SWOG-9133 RT w/ or w/o Doxorubicin and Vinblastine in Stage I or Stage II Hodgki

→ Lymphoma

NCT00147875 Study of Prednisone, Vinblastine, Doxorubicin, and Gemcitabine in Elderly Patien

→ Hodgkin's Disease

NCT00215046 Vinblastine and Methotrexate in Children With Pulmonary Vein Stenosis

→ Intraluminal Pulmonary Vein Stenosis

NCT00885534 Genetic Variates of Response to Cisplatin, Vinblastine, and Temozolomide (CVT) i

→ Melanoma|Skin Cancer

NCT01056679 Adriamycin, Vinblastine, DTIC and Revlimid in Elderly Hodgkin Lymphoma Patients

→ Hodgkin Lymphoma

NCT01135563 Study of Vinblastine and Sirolimus in Children With Recurrent/Refractory Solid T

→ Solid Tumors|Central Nervous System Tumors

NCT01887522 Study of Vinblastine in Combination With Nilotinib in Children, Adolescents, and

→ Refractory Low-grade Gliomas|Recurrent Low-grade G

NCT02343718 Vinblastine and Temsirolimus in Pediatrics With Recurrent or Refractory Lymphoma

→ Recurrent Lymphoma|Refractory Lymphoma|Solid Tumou

NCT02414568 Bendamustine Study in Classical Hodgkin Lymphoma Patients Over 60 Treated by Pre

→ Classical Hodgkin Lymphoma

NCT02670707 Vinblastine/Prednisone Versus Single Therapy With Cytarabine for Langerhans Cell

→ Langerhans Cell Histiocytosis

📚 PubMed References

3 · cited research

PMID 30082792 A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechani

Nat Commun

PMID 27270426 The ERK-ZEB1 pathway mediates epithelial-mesenchymal transition in pemetrexed re

Oncogene

PMID 35127485 Neutralizing Anti-IL-17A Antibody Demonstrates Preclinical Activity Enhanced by

Front Oncol

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables